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Huntsville Hospital

Approved Hospital Formulary

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Medications not yet evaluated by P&T are considered NON-FORMULARY . . . . . Always check 2 unique patient identifiers - NAME and DATE OF BIRTH - at every step! . . . . . Please be sure to document all clinical activities daily.

Huntsville Hospital

Approved Hospital Formulary

Suggestions or Corrections? Above and Beyond Nominations Formulary Request

Black Box Warning

Please review each of these drugs carefully.

abacavir	Hypersensitivity
abacavir-dolutegravir-lamiVUDine	Hypersensitivity Reactions, Lactic Acidosis and Severe Hepatomegaly; Exacerbations of Hepatitis B
abacavir-lamiVUDine	Abacavir: hypersensitivity reactions; lactic acidosis, hepatomegaly
abacavir-lamiVUDine-zidovudine	Hypersensitivity Reactions, Lactic Acidosis and Severe Hepatomegaly; Exacerbations of Hepatitis B
abobotulinumtoxinA	Distant spread of toxin effect
abrocitinib	Serious Infections, Mortality, Malignancy, Major Adverse Cardiovascular Events (MACE), and Thrombosis
acetaminophen	Hepatotoxicity
acetaminophen-codeine	Acetaminophen: Hepatotoxicity Codeine in children: death due to ultra-rapid metabolism
acetaminophen-HYDROcodone	Hepatotoxicity Extended release: Abuse; Respiratory Depression; Accidental Ingestion; Withdrawal; Interactions
acetaminophen-oxyCODONE	Addition, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; and Hepatotoxicity
acetaminophen-traMADol	Hepatotoxicity Addiction,Abuse,& Misuse; Life-Threatening Respiratory Depression; Accidential Ingestion; Neonatal Opioid Withdrawal Syndrome; Interation with Drugs Affecting Cytochrome P450 Isoenzymes;& Risks From Concomitant Use With Benzos or Other CNS Depressant
acetaminophen/butalbital/caffeine	Hepatotoxicity
acetylcysteine	Inhalation solution: not for injection
acitretin	Contraindication in Pregnancy; Teratogenicity; Ethanol Ingestion
adalimumab	Infection risk; malignancy in children and adolescents
adefovir	Exacerbation of Hepatitis; Nephrotoxicity; HIV Resistance; Lactic Acidosis, Severe Hepatomegaly
ado-trastuzumab emtansine	Hepatotoxicity, Cardiac Toxicity, Embryo-Fetal Toxicity
agalsidase beta	Hypersensitivity Reactions Including Anaphylaxis
alemtuzumab	Hematological toxicity; opportunistic infections
alglucosidase alfa	Anaphylaxis; Cardiorespiratory Failure
aliskiren	Fetal Toxicity
aliskiren-amLODIPine	Aliskiren: Pregnancy risk
aliskiren-amLODIPine-hydroCHLOROthiazide	Aliskiren: Pregnancy risk
aliskiren-hydroCHLOROthiazide	Aliskiren: Pregnancy risk
aliskiren-valsartan	Aliskiren: pregnancy risk
alogliptin-metFORMIN	metFORMIN: Lactic Acidosis
alogliptin-pioglitazone	Pioglitazone: congestive heart failure
alosetron	Serious GI Reactions; indication; discontinuation
ALPRAZolam	Risks From Concomitant Use in Opioids
alprostadil	Apnea
alvimopan	Short-term hospital use only
ambrisentan	Pregnancy risk; restricted distribution
amikacin	Neurotoxicity; nephrotoxicity
aMILoride	Hyperkalemia
aMILoride-hydroCHLOROthiazide	Amiloride: hyperkalemia
amino acids-electrolytes-dextrose-lipids	Death in Preterm Infants
amiodarone	Oral: Pneumonitis; Proarrhythmic Effects
amitriptyline	Suicidal ideation in children, adolescents
amitriptyline-perphenazine	Amitryptaline: Suicidal ideation in children, adolescents Perphenazine: Elderly patients with dementia related psychosis
amLODIPine-benazepril	Fetal Toxicity
amLODIPine-hydroCHLOROthiazide-valsartan	Fetal Toxicity
amLODIPine-olmesartan	Fetal Toxicity
amLODIPine-valsartan	Fetal Toxicity
amoxapine	Suicidal Ideation
amphetamine	Abuse/diversion potential; drug dependence
amphetamine sulfate	Abuse/diversion potential; drug dependence
amphetamine-dextroamphetamine	Abuse/diversion potential; drug dependence
amphotericin B	Noninvasive fungal disease; avoid overdose
amphotericin B cholesteryl sulfate	Noninvasive fungal disease; avoid overdose
amphotericin B lipid complex	Lipid Emulsions: Death in preterm infants
anti-thymocyte globulin (rabbit)	Used by Experienced Physicians in Immunosuppressive Therapy
apixaban	Discontinuation without anticoagulation
aprocitentan	Embryo-Fetal Toxicity
ARIPiprazole	Elderly patients with dementia related psychosis
arsenic trioxide	Cardiac toxicity
ascorbic acid-carbonyl iron	Iron Overdose Risk
asenapine	Mortality in elderly patients with dementia related psychosis
asfotase alfa	Hypersensitivity Reactions Including Anaphylaxis
asparaginase Erwinia chrysanthemi	Note: Latest labeling (3/2007) does not include prior boxed warning.
asparaginase Escherichia coli	Anaphylaxis; sudden death
atenolol-chlorTHALidone	Atenolol: avoid abrupt withdrawal
atoMOXetine	Suicidal Ideation
avalglucosidase alfa	Severe Hypersensitivity Reactions, Infusion-Associated Reactions, and Risk of Acute Cardiorespiratory Failure in Susceptible Patients
axicabtagene ciloleucel	Cytokine Release Syndrome and Neurologic Toxicities
azaTHIOprine	Risk of neoplasia, infections
azilsartan	Fetal Toxicity
azilsartan-chlorTHALidone	Fetal Toxicity
baclofen	Intrathecal: Abrupt discontinuation
bamlanivimab	Limitations of Authorized Use for COVID-19
baricitinib	Serious Infections, Mortality, Malignancy, Major Adverse Cardiovascular Events (MACE), and Thrombosis
becaplermin topical	Increased risk of secondary malignancy
bedaquiline	Increased mortality; QT prolongation
belatacept	Post transplant lymphoproliferative disorder; serious infections
belladonna-opium	Addiction, Abuse, And Misuse; Life-Threatening Respiratory Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; And Risks From Concomitant Use With Benzodiazepines Or Other Cns Depressants
belzutifan	Embryo-Fetal Toxicity
benazepril	Fetal Toxicity
benazepril-hydroCHLOROthiazide	Fetal Toxicity
bendroflumethiazide-nadolol	Nadolol: avoid abrupt withdrawal
benzathine penicillin-procaine penicillin	Not for Intravenous Use
bictegravir-emtricitabine-tenofovir alafenamide	Post Treatment Acute Exacerbation of Hepatitis B
bismuth subsalicylate-metroNIDAZOLE-tetracycline	Carcinogenicity
bleomycin	Pulmonary Fibrosis; Idiosyncratic Reactions
blinatumomab	Cytokine Release Syndrome and Neurological Toxities
bosentan	Hepatotoxicity; teratogenecity
brentuximab vedotin	Progressive Multifocal Leukoencephalopathy (PML)
brexpiprazole	Elderly patients with dementia-related psychosis; suicidal ideation
brexucabtagene autoleucel	Cytokine Release Syndrome, Neurologic Toxicities, And Secondary Hematological Malignancies
brincidofovir	Incresed Risk for Mortality When Used For Longer Duration
brodalumab	Suicidal Ideation and Behavior
budesonide-formoterol	Asthma Related Death
bumetanide	Potent diuretic
bupivacaine	Intravascular injection risk; 0.75% strength caution
bupivacaine-EPINEPHrine	Bupivacaine: Intravascular injection risk; 0.75% strength caution
buprenorphine-nalOXone	https://blackboxrx.com/warning/490
buPROPion	Suicidal Ideation
buPROPion-naltrexone	Bupropion: Suicidal ideation Naltrexone: Abuse liability Naltrexone: Hepatic injury with excessive dosing Contrave: Suicdal Thoughts and Behaviors; Neuropsychiatric Reactions
busulfan	Bone marrow suppression
butorphanol	Addiction, Abuse, And Misuse; Life-Threatening Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; and Risks From Concomitant Use With Benzodiazepines or Other CNS Depressants
cabazitaxel	Hemtalogical & Hypersensitivity Reactions
cabozantinib	Perforations and Fistulas and Hemorrhage
canagliflozin-metFORMIN	metFORMIN: Lactic Acidosis canagliflozin: Lower Limb Ampution
candesartan	Fetal Toxicity
candesartan-hydroCHLOROthiazide	Fetal Toxicity
capecitabine	Warfarin Interaction
captopril	Fetal Toxicity
captopril-hydroCHLOROthiazide	Fetal Toxicity
carBAMazepine	Hematological Risk; Serious Dermatologic Reactions
carbidopa	Bolded (not boxed): Carbidopa dosing
carbidopa-levodopa	Bolded (not boxed): Carbidopa dosing
carbidopa-levodopa-entacapone	Bolded (not boxed): Carbidopa dosing
carbonyl iron	Iron Overdose Risk
CARBOplatin	Myelosuppression; Anaphylaxis risk
carfilzomib	Cardiac Toxicities; Tumor Lysis Syndrome; Pumonary Toxicity; Dyspnea; Hyprertension
cariprazine	Increased Mortality in Elderly Patients with Dementia-Related Psychosis
carmustine	Bone Marrow Suppression; Pulmonary Toxicity
celecoxib	Cardiovascular, gastrointestinal risk
celecoxib-tramadol	Serious And Life-Threatening Risks From Use Of Seglentis
certolizumab	Serious infection risk
cetuximab	Infusion Reactions; Cardiopulmonary Arrest
chlorambucil	Bone marrow suppression; teratogen
chloramphenicol	Fatal blood dyscrasias
chlordiazePOXIDE	Risk From Concomitant Use With Opioids
chlordiazePOXIDE-amitriptyline	amitriptyline: Suicidal ideation in children, adolescents chlordiazePOXIDE: Risks From Concomitant Use With Opioids
chlordiazePOXIDE-clidinium	Risks From Concomitant Use With Opioids
chlorpheniramine-HYDROcodone-PSE	Risk from Concomitant Use with Benzodiazepines or Other CNS Depressants
chlorproMAZINE	Mortality in elderly with dementia
cidofovir	Nephrotoxicity; neutropenia
cilostazol	CHF patient contraindication
ciprofloxacin	Tendinitis; tendon rupture
CISplatin	Nephrotoxicity; Myelosuppression; Nausea and Vomiting; Ototoxicity; Anaphylactic like reactions; Avoid overdose or confusion with carboplatin and carboplatin-AQ
citalopram	Suicidal Thoughts and Behaviors
cladribine	Bone Marrow Suppression; Neurotoxicity; Nephrotoxicity
clindamycin	Clostridium difficile associated diarrhea
cloBAZam	Risk From Concomitant Use with Opioids
clomiPRAMINE	Suicidal Ideation
clonazePAM	Risk From Concomitant Use With Opioids
cloNIDine	Epidural Clonidine
clopidogrel	Poor CYP2C19 metabolizers
clorazepate	Risk From Concomitant Use With Opioids
cloZAPine	cloZAPine: severe neutropenia, myocarditis, seizure risk
coagulation factor VIIa	Serious Thrombotic Adverse Events Associated with Recombinant Coagulation Factor VIIa Outside Label Indicatons
coagulation factor Xa recombinant, inactivated-zhzo	Thromboembolic Risks, Ischemic Risks, Cardiac Arrest, and Sudden Deaths
cobicistat-elvitegravir-emtricitabine-tenofovir disoproxil fumarate	Lactic acidosis, severe hepatomegaly; hepB co-infection
codeine	Codeine in children: death due to ultra-rapid metabolism
collagenase clostridium histolyticum	Serious Penile Injury
conjugated estrogens	Endometrial cancer; cardiovascular; dementia risk
conjugated estrogens topical	Endometrial cancer; cardiovascular; dementia risk
conjugated estrogens-medroxyPROGESTERone	Cardiovascular and Other Risks
cycloSPORINE	Infection, neoplasm, nephrotoxicity risk
cytarabine	Prior to initiation of therapy
cytarabine liposomal	Chemical arachnoiditis
dabigatran	Discontinuation without anticoagulation
dacarbazine	Hemopoietic depression; hepatic necrosis risk
dalfopristin-quinupristin	Approved indication
dalteparin	Spinal/epidural hematoma risk
danazol	Pregnancy contraindication; stroke risk; hepatic risk with long term use; benign intracranial hypertension
dantrolene	Hepatitis risk
dapagliflozin-metFORMIN	metFORMIN: Lactic Acidosis
darbepoetin alfa	Mortality, serious CV events, tumor progression or recurrence
darunavir-cobicistat-emtricitabine-tenofovir alafenamide	Post Treatment Acture Exacerbation of Hepatitis B
dasabuvir-ombitasvir-paritaprevir-ritonavir	Ritonavir: Drug interaction risk
DAUNOrubicin	Cardiac, myelosuppression, extravasation risk
DAUNOrubicin liposomal	Cardiotoxicity; myelosuppresssion; infusion reaction
daunorubicin liposomal-cytarabine liposomal	Do Not Interchange with other Daunorubicin and/or Cytarabine Containing Products
deferasirox	Renal Failure, Hepatic Failure, GI Hemorrhage
delafloxacin	Serious Adverse Reactions Including Tendinitis, Tendon Rupture, Peripheral Neuropathy, Cental Nervous System Effects, and Exacerbation of Myasthenia Gravis
denosumab	Prolia - Severe Hypocalcemia in Patients with Advanced Kidney Disease
desipramine	Suicidal Ideation
desmopressin	Hyponatremia
desvenlafaxine	Suicidal ideation
deuruxolitinib	Serious Infections, Mortality, Malignancy, Major Adverse Cardiovascular Events (Mace) And Thrombosis
deutetrabenazine	Depression and suicidality
dexmethylphenidate	Caution in drug dependent patients; supervised withdrawal
dextroamphetamine	Abuse/diversion potential; drug dependence
dextromethorphan-quiNIDine	Quinidine: Active antiarrhythmic therapy may increase mortality
diatrizoate	Not for intrathecal use
diazepam	Risk From Concomitant Use With Opioids
diclofenac	Cardiovascular, gastrointestinal risk
diclofenac-miSOPROStol	Diclofenac: Cardiovascular, gastrointestinal risk miSOPROStol: Pregnancy risk
didanosine	Pancreatitis, hepatotoxicity, lactic acidosis risk
diflunisal	Cardiovascular, gastrointestinal risk
dihydroergotamine	Dihydroergotamine: drug interaction risk
dinoprostone topical	Suppository: use recommended dose
dinutuximab	Serious infusion reactions and neuropathy
disopyramide	Mortality Risk
disulfiram	Administer with patient consent
divalproex sodium	Hepatotoxicity; mitochondrial disease; fetal risk
DOCEtaxel	Hepatic dysfunction, hypersensitivity risk
dofetilide	Initiation or re-initiation monitoring
dolutegravir-lamivudine	Patients Co-Infected with Hepatitis B Virus (HBV) & Human Immunodeficiency Virus (HIV-1)
DOPamine	Peripheral ischemia risk
doravirine-lamiVUDine-tenofovir disoproxil fumarate	Post-Treatment Acute Exacerbation of Hepatitis B
doxepin	Suicidal Ideation
DOXOrubicin	Cardiac, hepatic, myelosuppression, extravasation risk
DOXOrubicin liposomal	Cardiac, acute infusion reaction, myelosuppresssion risk
dronedarone	Contraindication in certain CHF conditions
droperidol	QT prolongation; cardiac risk
drospirenone-estradiol	Cardiovascular and Other Risks
droxidopa	Supine Hypertension
dulaglutide	Risk of thyroid C-cell tumors
DULoxetine	Suicidal Ideation
duvelisib	Fatal and Serious Toxicities: Infections, Diarrhea or Colitis, Cutaneous Reactions, and Pneumonitis
ecallantide	Anaphylaxis
eculizumab	Meningococcal Infection
edetate calcium disodium	Lead Encephalopathy Risk
edoxaban	Reduced efficacy; risk of ischemic events; spinal/epidural hematoma
efalizumab	Risk of Serious Infections, Progressive Multifocal Leukoencephalopathy
efavirenz-emtricitabine-tenofovir disoproxil fumarate	Lactic Acidosis; Severe Hepatomegaly with Steatosis and Post Treatment Exacerbation of Hepatitis B
efavirenz-lamiVUDine-tenofovir disoproxil fumarate	Post Treatment Acute Exacerbations of Hepatitis B
elbasvir-grazoprevir	Risk of Hepatitis B Virus Reactivation in Patients Coinfected with HCV and HBV
elivaldogene autotemcel	HEMATOLOGIC MALIGNANCY
elosulfase alfa	Risk of Anaphylaxis
eltrombopag	Risk for Hepatotoxicity, Restricted Distribution
elvitegravir-cobicistat-emtricitabine-tenofovir alafenamide	Emtricitabine: Lactic Acidosis, Severe Hepatomegaly tenofovir: Lactic acidosis, severe hepatomegaly; hepB co-infection
emicizumab	Thrombotic Microangiopathy and Thromboembolism
empagliflozin-metFORMIN	metFORMIN: Lactic acidosis
emtricitabine	Lactic Acidosis, Severe Hepatomegaly
emtricitabine-rilpivirine-tenofovir alafenamide	Emtricitabine: Lactic Acidosis, Severe Hepatomegaly Tenofovir: Lactic acidosis, severe hepatomegaly; hepB co-infection
emtricitabine-rilpivirine-tenofovir disoproxil fumarate	Lactic Acidosis; Severe Hepatomegaly; hepB co-infection
emtricitabine-tenofovir alafenamide	Emtricitabine: Lactic Acidosis, Severe Hepatomegaly Tenofovir: Lactic acidosis, severe hepatomegaly; hepB co-infection
emtricitabine-tenofovir disoproxil fumarate	Lactic Aacidosis; severe hepatomegaly; hep B co-infection
enalapril	Fetal Toxicity
enalapril-felodipine	Enalapril: pregnancy risk
enalapril-hydroCHLOROthiazide	Fetal Toxicity
enasidenib	Differentiation Syndrome
enoxaparin	Spinal/epidural hematoma risk
entecavir	Lactic acidosis, severe hepatomegaly; hepB co-infection
epiRUBicin	Myocardial toxicity; extravasation
epoetin alfa	Risk of mortality, tumor progression, cardiac events
eprosartan	Eprosartan: Pregnancy risk
eprosartan-hydroCHLOROthiazide	Eprosartan: pregnancy risk
ertugliflozin-metFORMIN	metFORMIN: Lactic Acidosis
escitalopram	Suicidal ideation
Esketamine	Sedation; Dissociation; Abuse and Misuse; and Surcidal Thoughts and Behaviors
estazolam	Risk From Concomitant Use With Opioids
esterified estrogens	Endometrial cancer; cardiovascular; dementia risk
esterified estrogens-methylTESTOSTERone	Endometrial cancer; cardiovascular; dementia risk
estradiol	Transdermal: endometrial cancer; cardiovascular; dementia risk Vaginal cream/tab: endometrial cancer; cardiovascular; dementia risk
estradiol topical	Endometrial cancer; cardiovascular; dementia risk
estradiol-levonorgestrel	Cardiovascular and Other Risks
estradiol-norethindrone	Cardiovascular and other risks; probable dementia
estradiol-progesterone	Cardiovasular Disorders, Breast Cancer, Endometrial Cancer, and Probable Dementia
estropipate	Endometrial cancer; cardiovascular; dementia risk
eszopiclone	Risk of Serious Injuries With Certain Prescription Insomnia Medications
etanercept	Infection risk; tuberculosis
ethacrynic acid	Potent Diuretic
ethinyl estradiol-levonorgestrel	Cigarette smoking; risk of cardiovascular disease
ethinyl estradiol-norgestrel	Cigarette smoking; risk of cardiovascular disease
etodolac	Cardiovascular; gastrointestinal risk
etoposide	Myelosuppression risk
everolimus	Malignancies and Serious Infections, Nephrotoxicity, Kidney Graft Thrombosis, Mortality in Heart Transplantation
exenatide	Extended Release Injection: Risk of thyroid c-cell tumors
ezogabine	Retinal Abnormalities and Vision Loss
famotidine-ibuprofen	Cardiovascular; gastrointestinal risk
fat emulsion, intravenous	Cautious use in infants Death in preterm infants
febuxostat	Cardiovascular Death
fedratinib	Encephalopathy Including Wernicke's
felbamate	Aplastic anemia; liver failure risk
fenfluramine	Valvular Heart Disease and Pulmonary Arterial Hypertension
fenoprofen	Cardiovascular, gastrointestinal risk
fentaNYL	Buccal Tablet: Serious adverse events, deaths; abuse potential Nasal Spray: Schedule II Controlled Substance: Abuse potential Sublingual Spray: Risk of respiratory depression, medication errors, abuse potential Transdermal: High concentration of Schedule II opioid agonist
ferrous fumarate	Iron Overdose Risk
ferrous fumarate-folic acid	Iron Overdose Risk
ferrous fumarate-iron polysaccharide	Iron Overdose Risk
ferrous gluconate	Iron Overdose Risk
ferrous sulfate	Iron Overdose Risk
ferumoxytol	Risk For Serious Hypersensitivity/Anaphylaxis Reactions
fezolinetant	Hepatotoxicity
flecainide	Cardiovascular risk
flibanserin	Hypotension and Syncope in Certain Settings
flucytosine	Hepatic, hematologic risks; caution in renal impairment
fludarabine	Neurotoxicity, hemolytic anemia risk
fluorouracil	Hematologic risk
fluorouracil topical	Hematologic risk
FLUoxetine	Suicidal Ideation
FLUoxetine-OLANZapine	Sucidal Thoughts and Behaviors; Increased Mortality in Elderly Patients with Dementia-Related Psychosis
fluPHENAZine	Mortality in elderly with dementia
flurazepam	Risk From Concomitant Use With Opioids
flurbiprofen	Cardiovascular, gastrointestinal risk
flutamide	Hepatotoxicity
fluticasone-salmeterol	Salmeterol: asthma related death; pediatric and adolescent patients
fluticasone-vilanterol	Vilanterol: Asthma-related death
fluvoxaMINE	Suicidal Ideation
fondaparinux	Spinal/epidural hematoma risk
formoterol	Asthma Related Death
formoterol-mometasone	Asthma Related Death
foscarnet	Nephrotoxicity; seizure risk
fosinopril	Fetal Toxicity
fosinopril-hydroCHLOROthiazide	Fetal Toxicity
fosphenytoin	Cardiovascular risk with rapid infusion
furosemide	Potent Diuretic
gadobenate dimeglumine	Nephrogenic Systemic Fibrosis
gadobutrol	Nephrogenic Systemic Fibrosis; NOT FOR INTRATHECAL USE
gadoteridol	Nephrogenic Systemic Fibrosis; NOT FOR INTRATHECAL USE
gadoxetate	Nephrogenic Systemic Fibrosis
ganciclovir	Hematological toxicity; IV and oral different indications
gemifloxacin	Tendinitis, Tendon Rupture
gemtuzumab ozogamicin	Hepatotoxicity
gentamicin	Ototoxicity; Nephrotoxocity
gepirone	Suicidal Thoughts and Behaviors
gilteritinib	Differentiation Syndrome
glasdegib	Embryo-Fetal Toxicity
glecaprevir-pibrentasvir	Risk of Hepatitis B Virus Reactivation in Patients Coninfectd with HCV and HBV
glimepiride-pioglitazone	Pioglitazone: congestive heart failure
glimepiride-rosiglitazone	Rosiglitazone: Congestive Heart Failure; Myocardial Infarction
glipiZIDE-metFORMIN	metFORMIN: Lactic Acidosis
glyBURIDE-metFORMIN	metFORMIN: Lactic Acidosis
glycopyrrolate	Asthma-related death
glycopyrrolate-formoterol	Asthma Related Death
golimumab	Risk of Serious Infections, Malignancy in Children and Adolescents
guaiFENesin-codeine	Codeine in children: death due to ultra-rapid metabolism
haloperidol	Mortality in elderly with dementia
hemin	Use only after alternate therapy failure
heparin	Spinal/Epidural Hematomas
hetastarch	Renal injury risk
hydroCHLOROthiazide-methyldopa	Individualize dose
HYDROcodone	Extended release: Abuse; Respiratory Depression; Accidental Ingestion; Withdrawal; Interactions
HYDROcodone-chlorpheniramine	Risk from Concomitant Use with Benzodiazepines or Other CNS Depressants
HYDROcodone-guaiFENesin	Risk from Concomitant Use with Benzodiazepines or Other CNS Depressants
HYDROcodone-homatropine	Risk from Concomitant Use with Benzodiazepines or Other CNS Depressants
HYDROcodone-ibuprofen	Cardiovascular; gastrointestinal risk
HYDROcodone-pseudoephedrine	Risk from Concomitant Use with Benzodiazepines or Other CNS Depressants
HYDROmorphone	Injection: Respiratory depression risk; abuse potential Injection, High Potency: Opioid-tolerant patients only; Respiratory depression risk; abuse potential Oral, extended release: Opioid-tolerant patients only; overdose risk; abuse potential Oral, liquid & tablets: Abuse potential; respiratory depression; neonatal withdrawal; alcohol interaction
hydroxyethyl starch	Mortality and Renal Injury Requiring Renal Replacement Therapy
hydroxyurea	Prior to initiation of therapy
ibrexafungerp	Risk of Embryo-Fetal Toxicity
ibuprofen	Cardiovascular; gastrointestinal risk
ibutilide	Potentially Fatal Arrhythmias
IDArubicin	Cardiotoxicity; myelosuppression; renal/hepatic impairment; avoid extravasation
idecabtagene vicleucel	Cytokine Release Syndrome, Neurologic Toxicities, HLM/MAS and Prolonged Cytopenia and Secondary Hematological Malignancies
idelalisib	Fatal and Serious Toxicities: Hepatic, Severe Diarrhea, Colitis, Pneumonitis, and Intestinal Perforation
idursulfase	Anaphylaxis risk
ifosfamide	Urotoxicity; myelosuppressionm CNS toxicity
iloperidone	Mortality in elderly patients with dementia related psychosis
imiglucerase	Hypersensitivity Reactions Including Anaphylaxis
imipramine	Suicidal ideation
immune globulin intravenous	Renal dysfunction, acute renal failure
immune globulin subcutaneous	Renal dysfunction, acute renal failure
indacaterol	Asthma-related death
indomethacin	Cardiovascular; gastrointestinal risk
inFLIXimab	Serious infection risk; hepatosplenic t-cell lymphomas; malignancy
Inotersen	Thrombocytopenia and Glomerulonephritis
inotuzumab ozogamicin	Hepatotoxicity, Including VOD; Increased Risk of Post-HSCT Non-Relapse Mortality
insulin degludec-liraglutide	Risk of Thyroid C-Cell Tumors
insulin inhaled	Risk of Acute Bronchospasm in Patients with Chronic Lung Disease
interferon alfa-2a	Neuropsychiatric, autoimmune, ischemic and infectious disorders
interferon alfa-2b	Neuropsychiatric, autoimmune, ischemic and infectious disorders
iodixanol	Not for intrathecal use
iohexol	Not for intrathecal use
ioversol	Not for Intrathecal
ipilimumab	Immune-Mediated Adverse Reactions
irbesartan	Fetal Toxicity
irbesartan-hydroCHLOROthiazide	Irbesartan: pregnancy risk
irinotecan	Severe diarrhea
irinotecan liposomal	Severe diarrhea
iron dextran	Injection: Anaphylactic reaction risk
iron sucrose	Iron overdose risk
isocarboxazide	Suicidal ideation
isoniazid	Hepatitis
ISOtretinoin	Contraindication in Pregnancy, Teratogenicity; Special Prescribing Requirements
itraconazole	Congestive heart failure, drug interactions
ivosidenib	Differentiation Syndrome
ixabepilone	Toxicity in hepatic impariment
ketamine	Emergence reactions; psychological manifestations
ketoconazole	Oral: hepatoxicity, drug interactions
ketoprofen	Cardiovascular; gastrointestinal risk
ketorolac	Duration of therapy; max dose; GI, cardiovascular, bleeding, renal risk Sprix: Risk of Serious Cardiovascular and Gastrointestinal Events
lamiVUDine	Lactic acidosis, hepatomegaly; exacerbations of hepatitis b; dosing formulation
lamiVUDine-tenofovir disoproxil fumarate	Post Treatment Acute Exacerbation of Hepatitis B
lamiVUDine-zidovudine	lamiVUDine: Lactic acidosis, hepatomegaly; exacerbations of hepatitis b; dosing formulation Zidovudine: Hematological adverse events; myopathy; lactic acidosis; hepatomegaly
lamoTRIgine	Serious dermatological reactions
lapatinib	Hepatotoxicity
laronidase	Risk of Anaphylaxis
ledipasvir-sofosbuvir	Risk of Hepatitis B Virus Reactivation in Patients Coinfected with HCV and HBV
leflunomide	Pregnancy risk; Hepatotoxicity
lenacapavir	Risk of Drug Resistance With Use of Yeztugo for HIV-1 Pre-Exposure Prophylaxis (Prep) in Undiagnosed HIV-1 Infection
lenalidomide	Embryo-Fetal Toxicity and Restricted Distribution Program, Hematologic Toxicity, Venous Thromboembolism
lesinurad	Risk of Acute Renal Failure, More Common When Used Without a Xanthine Oxidase Inhibitor
levoFLOXacin	Tendinitis, tendon rupture
levomilnacipran	Suicidal Ideation
levonorgestrel	Bolded (not boxed): Not Protective Against HIV
levorphanol	Serious and Life-Threatening Risks From Use Of Levorphanol Tartrate Tablets
levothyroxine	Treatment of obesity or weight loss
lidocaine topical	Lidocaine, viscous: Do NOT use for teething pain
linaCLOtide	Contraindicated in patients <6 years of age; Avoid use in patients 6-17 years of age
linaGLIPtin-metFORMIN	metFORMIN: Lactic Acidosis
liothyronine	Treatment of obesity or weight loss
liraglutide	Thyroid C-cell Tumors
lisdexamfetamine	High abuse/diversion potential; drug dependence
lisinopril	Fetal Toxicity
lisinopril-hydroCHLOROthiazide	Lisinopril: pregnancy risk
lisocabtagene maraleucel	Cytokine Release Syndrome, Neurologic Toxicities and Secondary Hematological Malignancies
lithium	Monitoring recommendations
lomitapide	Risk of Hepatotoxicity
lomustine	Bone marrow suppression
lopinavir-ritonavir	Ritonavir: Drug interactions
LORazepam	Risks From Concomitant Use With Opioids
losartan	Fetal Toxicity
losartan-hydroCHLOROthiazide	Angiotensin II antagonist pregnancy risk
lovotibeglogene autotemcel	Hematologic Malignancy
loxapine	Elderly patients with dementia related psychosis Aerosol: Bronchospasm
lumateperone	Increased Mortality In Elderly Patients With Dementia-Related Psychosis; and Suicidal Thoughts And Behaviors
lurasidone	Mortality in elderly patients with dementia related psychosis
lymphocyte immune globulin, anti-thy (equine)	Prior to initiation of therapy
macitentan	Embryo-Fetal Toxicity
mannitol	Severe bronchospasm risk
maprotiline	Suicidal ideation
maraviroc	Hepatotoxicity
Margetuximab-cmkb	Left Ventricular Dysfunction and Embryo-Fetal Toxicity
mavacamten	Risk of heart failure
mechlorethamine	Prior to initiation of therapy
mechlorethamine topical	Prior to initiation of therapy
medroxyPROGESTERone	Cardiovascular and other risks
mefenamic acid	Cardiovascular; gastrointestinal risk
mefloquine	Neuropsychiatric events
meloxicam	Cardiovascular; gastrointestinal risk
melphalan	Bone marrow suppression; hypersensitivity reactions; pregnancy risk
meperidine	Addiction, Abuse, and Misuse; Life -Threatening Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; Cytoshrome P450 3A4 interaction; Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants; and MOAI Interactions
meperidine-promethazine	Promethazine: Patients < 2 years; severe tissue injury Addiction, Abuse, and Misuse; Life -Threatening Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; Cytoshrome P450 3A4 interaction; Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants; and MOAI Interactions
mercaptopurine	Bolded (not boxed): initiation of therapy
mesoridazine	QTc Prolongation is dose related. Has been associated with torsades de pointes type arrhythmias and sudden death
metFORMIN	Lactic Acidosis
metFORMIN-pioglitazone	Metformin: Lactic Acidosis Pioglitazone: congestive heart failure
metFORMIN-repaglinide	Metformin: Lactic Acidosis
metFORMIN-rosiglitazone	Metformin: Lactic Acidosis Rosiglitazone: Congestive Heart Failure; Myocardial Infarction
metFORMIN-SITagliptin	metFORMIN: Lactic Acidosis
methacholine	Diagnostic use only
methadone	Risk during initiation of or conversion to methadone
methohexital	Continuous monitoring of respiratory and cardiac function
methotrexate	Bone marrow, liver, lung and kidney toxicity risk
methyldopa	Fixed combination for initial hypertension management
methylene blue	Serotonin Syndrome with Concomitant Use of Serotonergic Drugs
methylphenidate	Tolerance and dependence
methylphenidate_old	Tolerance and dependence
methylTESTOSTERone	Endometrial cancer risk (estrogens)
metoclopramide	Tardive Dyskinesia
metOLazone	Bolded (not boxed): do not interchange
metroNIDAZOLE	Carcinogenicity
mexiletine	Mortality; Acute Liver Injury
midazolam	Individualize dose
midodrine	Supine blood pressure > 180 mmHg
milnacipran	Suicidal ideation
miltefosine	Embryo-Fetal Toxicity
minoxidil	Antihypertensive risk
mipomersen	Hepatotoxicity risk
mirtazapine	Suicidal ideation
miSOPROStol	Pregnancy risk
mitoMYcin	Bone marrow suppression; hemolytic uremic syndrome
mitoXANTRONE	Cardiotoxicity; baseline neutrophil count; extravasation risk
mobocertinib	OTC Prolongation and Torsades De Pointes
moexipril	Fetal Toxicity
moexipril-hydroCHLOROthiazide	Moexipril: pregnancy risk
molindone	Elderly patients with dementia related psychosis
Molnupiravir	Mandatory requirements for administration of molnupiravir under emergency use authorization.
montelukast	Serious Neuropsychiatric Events
morphine	Injection: 24-hour observation following epidural/intrathecal administration Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; and Interaction with Alcohol (last warning only for products that have an interaction with alcohol)
morphine liposomal	Controlled Substance, Abuse Liability
morphine-naltrexone	Abuse Liability
moxetumomab pasudotox-tdfk	Capillary Leak Syndrome and Hemolytic Uremic Syndrome
moxifloxacin	Tendinitis, tendon rupture
multivitamin with iron	Iron overdose risk
multivitamin with iron and fluoride	Iron overdose risk
mycophenolate mofetil	Embryofetal Toxicity, Malignancies, and Serious Infections
mycophenolic acid	Embryofetal Toxicity, Malignancies, and Serious Infections
nabumetone	Cardiovascular; gastrointestinal risk
nalBUPHine	Life-Threatening Respiratory Depression and Risks From Concomitant Use With Benzodiazepines or Other CNS Depressants
nalOXone-oxyCODONE	Abuse potential
naproxen	Cardiovascular; gastrointestinal risk
naproxen-esomeprazole	Potential serious cardiovascular and gastrointestinal adverse events
naproxen-SUMAtriptan	Naproxen: Cardiovascular; gastrointestinal risk
natalizumab	Progressive multifocal leukoencephalopathy (PML)
nebivolol-valsartan	Fetal Toxicity
necitumumab	Cardiopulmonary Arrest and Hypomagnesemia
nefazodone	Hepatotoxicity; Suicidal Ideation
nelarabine	Prior to initiation of therapy; neurologic events
neomycin	Neurotoxicity, nephrotoxicity, ototoxicity; general toxicity
nevirapine	Hepatotoxicity; dermal reactions; patient monitoring
nilotinib	QT Prolongation and Sudden Death
niMODipine	Serious harm with IV administration of oral product
nirmatrelvir-ritonavir	Risk of Serious Adverse Reactions Due to Drug Interactions
nitroPRUSSide	Cyanide toxicity; hypotension risk; dilute
norepinephrine	Extravasation risk
norethindrone	Cigarette smoking; risk of cardiovascular disease
norfloxacin	Tendinitis, tendon rupture
nortriptyline	Suicidal ideation
obeticholic acid	Hepatic Decompensation and Failure in Incorrectly Dosed PBC Patients with Child-Puch Class B or C or Decompensated Cirrhosis
obiltoxaximab	Hypersensitivity and Anaphylaxis
obinutuzumab	Hepatitis B Virus Reactivation and Progressive Multifocal Leukoencephalopathy
ofatumumab	Hepatitis B Virus (HBV) Reactivation/Progressive Multifocal Leukoencephalopathy
ofloxacin	Tendon Rupture, Tendinitis
OLANZapine	Mortality in elderly with dementia related psychosis
oliceridine	Serious And Life-Threatening Risks
olmesartan	Fetal Toxicity
olmesartan-amLODIPine-hydroCHLOROthiazide	Olmesartan: pregnancy risk
olmesartan-hydroCHLOROthiazide	Olmesartan: pregnancy risk
olutasidenib	Differentiation Syndrome
omalizumab	Anaphylaxis
ombitasvir-paritaprevir-ritonavir	Ritonavir: Drug interaction risk
onabotulinumtoxinA	Distant spread of toxin effect
oprelvekin	Allergic reactions, including anaphylaxis
ospemifene	Endometrial Cancer; Cardiovascular Disorders
oxaliplatin	Anaphylactic-like reactions
oxandrolone	Peliosis hepatitis; Liver Cell Tumors; Blood Lipid Changes
oxaprozin	Cardiovascular; gastrointestinal risk
oxazepam	Risk From Concomitant Use With Opioids
oxyCODONE	Oral solution: Risk of errors Controlled release: Abuse potential
oxyCODONE-ibuprofen	Ibuprofen: Cardiovascular; gastrointestinal risk oxyCODONE: Abuse Potential
oxyCODONE-naltrexone	Addition, Abuse, and Misuse; Life-Threatening Respiratory Depression; Accidental Ingestion; Neonatal Opioid Withdrawal Syndrome; and Cytochrome P450 3A4 Interaction
oxyMORphone	Abuse/diversion potential; drug dependence
oxytocin	Elective induction of labor
PACLitaxel	Prior to initiation of therapy
PACLitaxel protein-bound	Prior to initiation of therapy
paliperidone	Mortality in elderly patients with dementia related psychosis
pancuronium	Bolded (not boxed): adequate training
panitumumab	Dermatologic toxicity; infusion reactions
panobinostat	Fatal and serious toxicities; severe diarrhea and cardiac toxicities
parathyroid hormone	Potential risk of osteosarcoma
PARoxetine	Suicidal ideation
PAZOPanib	Severe and fatal hepatotoxicity has been observed in clinical studies.
pegcetacoplan	Serious Infections Caused By Encapsulated Bacteria
peginterferon alfa-2a	Neuropsychiatric, autoimmune, ischemic and infectious disorders
peginterferon alfa-2b	Neuropsychiatric, autoimmune, ischemic and infectious disorders
pegloticase	Anaphylaxis and Infusion Reactions
pegunigalsidase alfa	Hypersensitivity Reactions Including Anaphylaxis
pemivibart	Anaphylaxis
penicillAMINE	Toxicity risk
penicillin G benzathine	Not for intravenous use
pentazocine	Oral use only; lethal risk from misuse by injection
pentazocine-nalOXone	Oral use only
pentostatin	Prior to initiation of therapy
perampanel	Serious psychiatric and behavioral reactions
perflutren	Serious cardiopulmonary reactions
pergolide	Drug Withdrawn from US Market in March -2007
perindopril	Fetal Toxicity
perindopril-amLODIPine	Perindopril: pregnancy risk
Peritoneal Dialysis Solution	Unrecognized Hypoglycemia Resulting From Drug-Device Interaction
perphenazine	Elderly patients with dementia related psychosis
pertuzumab	Cardiomyopathy; Embryo-Fetal Toxicity
Pexidartinib	Hepatotoxicity
phenelzine	Suicidal ideation
phentermine-topiramate	Can Be Abused or Lead to Drug Dependence
phenylephrine	Prior to initiation of therapy
phenytoin	Cardiovascular risk with rapid infusion
phytonadione	Severe reactions with IV use
pimavanserin	Incresaed Mortality in Elderly Patients with Dementia-Related Psychosis
pimecrolimus topical	Long-term safety
pimozide	Elderly patients with dementia related psychosis
pioglitazone	Congestive heart failure
piroxicam	Cardiovascular; gastrointestinal risk
plazomicin	Nephrotoxicity, Ototoxicity, Neuromuscular Blockade and Fetal Harm
plecanatide	Risk of Serious Dehydration in Pediatric Patients
polymyxin B sulfate	Parenteral use: nephrotoxicity, neurotoxicity, pregnancy risk
pomalidomide	Embryo-Fetal Toxicity; Venous and Arterial Thromboembolism
PONATinib	Arterial Occlusive Events, Venous Thromboembolic Events, Heart Failure, and Hepatotoxicity
potassium phosphate-sodium phosphate	Sodium Phosphate: Acute Phosphate Nephropathy
pramlintide	Pramlintide is used with insulin and has been associated with an increased risk of insulin-induced severe hypoglycemia, particularly in patients with type 1 diabetes.
prasugrel	Bleeding risk
procainamide	Positive titers with chronic administration
procarbazine	Prior to initiation of therapy
prochlorperazine	Elderly patients with dementia related psychosis
progesterone	Cardiovascular disorders; breast cancer; probable dementia
progesterone topical	Cardiovascular disorders; breast cancer; probable dementia
promethazine	Patients < 2 years; severe tissue injury
promethazine-codeine	Codeine in children: death due to ultra-rapid metabolism Promethazine: contraindicated in patients < 2 years
promethazine-dextromethorphan	Promethazine: Contraindicated in patients < 2 years
promethazine-phenylephrine	Promethazine: Patients < 2 years; respiratory depression
promethazine-phenylephrine-codeine	Codeine in children: death due to ultra-rapid metabolism Promethazine: contraindicated in patients < 2 years
propafenone	Mortality (CAST trial results)
propylthiouracil	Severe liver injury; acute liver failure
protamine	Hypotension, pulmonary hypertension; risk factors described
prothrombin complex	Arterial and venous thromboembolic complications
protriptyline	Suicidal ideation
quazepam	Risk From Concomitant Use With Opioids
QUEtiapine	Elderly patients with dementia related psychosis
quinapril	Fetal Toxicity
quinapril-hydroCHLOROthiazide	Quinapril: pregnancy risk
quiNIDine	Active antiarrhythmic therapy may increase mortality
quiNINE	No benefit in leg cramps; hematologic risks
quizartinib	QT Prolongation, Torsades DE Pointes, and Cardia Arrest
raloxifene	Risk of VTE and death from stroke
ramipril	Fetal Toxicity
ranibizumab	Endophthalmitis
rasburicase	Anaphylaxis; hemolysis; methemoglobinemia; uric acid measure interference
ravulizumab	Serious Meningococcal Infections
regorafenib	Hepatotoxicity
remdesivir	Black Box Warning is for Use of Remdesivir to Treat COVID-19. Remdesivir Must Be Administered by Intravenous (IV) Infusion.
remifentanil	Addiction, Abuse, and Misuse
reslizumab	Anaphylaxis
revumenib	Differentiation Syndrome
RHo (D) immune globulin	Intravascular Hemolysis
ribavirin	Oral: Monotherapy; hemolytic anemia; teratogenicity Inhalation: Respiratory function deterioration
rimabotulinumtoxinB	Distant Spread of Toxin Effect
riociguat	Embryo-Fetal Toxicity
risperiDONE	Elderly patients with dementia related psychosis
ritlecitinib	Serious Infections, Mortality, Malignancy, Major Adverse Cardiovascular Events (MACE), and Thrombosis
ritonavir	Drug interaction risk
riTUXimab	Fatal infusion reaction; mucocutaneous reactions; progressive multifocal leukoencephalopathy; hep b reactivation
riTUXimab-hyaluronidase	Fatal Infusion Reaction; Mucocutaneous Reactions; Progressive Multifocal Leukoencephalopathy; Hep b Reactivation
rivaroxaban	Premature discontinuation; spinal/epidural hematomas
rocuronium	Prior to initiation of therapy
ropeginterferon alfa-2b	RISK OF SERIOUS DISORDER
rosiglitazone	Congestive Heart Failure; Myocardial Infarction
rubidium-82 chloride	Unintended Strontium-82 (Sr-82) and Strontium-85 (Sr-85) Radiation Exposure
sacituzumab govitecan	Neutropenia and Diarrhea
sacubitril-valsartan	Fetal Toxicity
salmeterol	Asthma Related Deaths
salsalate	Cardiovascular; gastrointestinal risk
sarilumab	Risk of Infections
sAXagliptin-metFORMIN	metFORMIN: Lactic Acidosis
sebelipase alfa	Hypersensitivity Reactions Including Anaphylaxis
selegiline	Suicidal ideation
semaglutide	Risk of Thyroid C-Cell Tumors
sertraline	Suicidal ideation
simeprevir	Risk of Hepatitis B Virus Reactivation in Patients Coinfected with HCV and HBV
sirolimus	Immunosuppression; liver or lung transplant patients
sodium biphosphate-sodium phosphate	Sodium Phosphate: Acute Phosphate Nephropathy
sodium nitrite-sodium thiosulfate	Life Threatening Hypotension and Methemoglobin Formation
sodium oxybate	Central Nervous System Depression and Misuse and Abuse
sodium phosphate	Acute Phosphate Nephropathy
sofosbuvir	Risk of Hepatitis B Virus Reactivation in Patients Coinfected with HCV and HBV
sofosbuvir-velpatasvir	Risk of Hepatitis B Virus Reactivation in Patients Coinfected with HCV and HBV
sofosbuvir-velpatasvir-voxilaprevir	Risk of Hepatitis B Virus Reactivation in Patients Coinfected with HCV and HBV
sonidegib	Embryo-Fetal Toxicity
sotalol	Therapy initiation; renal impairment caution; product selection
spironolactone-hydroCHLOROthiazide	Possible tumorigen
steven-Test	(tenofovir alafenamide) Lactic Acidosis/Severe Hepatomegaly; Acute Exacerbation of Hepatitis (emtricitabine) Lactic Acidosis, Severe Hepatomegaly: Patients co-infected with HIV and Hepatitis B Virus
streptomycin	Neurotoxicity; nephrotoxicity
succinylcholine	Hyperkalemic rhabdomyolysis in infants or children
SUFentanil	Addiction, Abuse, and Misuse
sulindac	Cardiovascular; gastrointestinal risk
SUNItinib	Hepatotoxicity has been observed in clinical trials and post-marketing experience. This hepatotoxicity may be severe and deaths have been reported.
tacrolimus	Lymphoma risk; infection related to immunosuppression
tacrolimus topical	Long-term safety
Tagraxofusp-erzs	Capillary Leak Syndrome
tamoxifen	Women at high risk for breast cancer; women with DCIS
tapentadol	Abuse potential; limitations of use
telaprevir	Serious Skin Reactions
telavancin	Increased Mortality; Nephrotoxicity; Fetal Risk
telmisartan	Fetal Toxicity
telmisartan-amLODIPine	Telmisartan: pregnancy risk
telmisartan-hydroCHLOROthiazide	Telmisartan: pregnancy risk
temazepam	Risk From Concomitant Use With Opioids
teniposide	Myelosuppression; hypersensitivity reactions
tenofovir alafenamide	Lactic Acidosis/ Severe Hepatomegaly; Acute Exacerberation of Hepatitis
tenofovir disoproxil fumarate	Lactic acidosis, severe hepatomegaly; hepB co-infection
terbutaline	Preterm labor (injectable and oral)
teriflunomide	Severe liver injury, including fatal liver failure has been reported in patients treated with leflunomide, which is indicated for rheumatoid arthritis. A similar risk would be expected for teriflunomide.
terlipressin	Serious or fatal respiratory failure
testosterone	Secondary exposure to testosterone Serious pulmonary oil microembolism (POME) reactions and anaphylaxis
tetrabenazine	Depression and Suicidality
thalidomide	Teratogen; Venous Thromboembolism
thioridazine	QTc prolongation; elderly with dementia related psychosis
thiotepa	Severe Myelosuppression, Carcinogenicity
thiothixene	Elderly patients with dementia related psychosis
thrombin topical	Bleeding, thrombosis risk
thyroid desiccated	Treatment of obesity or weight loss
ticagrelor	Bleeding Risk; Aspirin and Brilinta Effectiveness
ticlopidine	Severe hematological adverse events
tigecycline	All cause mortality
tinidazole	Carcinogenecity has been seen in mice and rats treated chronically with metronidazole, another agent in the nitroimidazole class.
tinzaparin	Spinal/Epidural Hematomas
tiotropium-olodaterol	Asthma-Related Death
tipranavir	Both fatal and nonfatal intracranial hemorrhage have been reported.
tirzepatide	RISK OF THYROID C-CELL TUMORS
tisagenlecleucel	Cytokine Release Syndrome, Neurological Toxicities, And Secondary Hematological Malignancies
tisotumab vedotin	Ocular Toxicity
tiZANidine	Bolded (not boxed): bioequivalence between products
tobramycin	Ototoxicity, nephrotoxicity risk with IV use
tocilizumab	Serious infections risk
tofacitinib	Patients treated with tofacitinib citrate are at increased risk for developing serious infections that may lead to hospitalization or death
tolmetin	Cardiovascular, gastrointestinal risk
tolvaptan	Initiation or re-initiation monitoring
topotecan	Bone marrow suppression
toremifene	QT Prolongation, Avoid CYP3A4 Inhibitors
tositumomab	Hypersensitivity; Cytopenia; FDA Pregnancy Category X
traMADol	Addiction,Abuse,& Misuse; Life-Threatening Respiratory Depression; Accidential Ingestion; Neonatal Opioid Withdrawal Syndrome; Interation with Drugs Affecting Cytochrome P450 Isoenzymes;& Risks From Concomitant Use With Benzos or Other CNS Depressant
trandolapril	Fetal Toxicity
trandolapril-verapamil	Fetal Toxicity
tranexamic acid	Risk of Medication Errors Due to Incorrect Route of Administration
tranylcypromine	Suicidal ideation
trastuzumab	Cardiomyopathy; infusion reactions, pulmonary toxicity; teratogenicity
trastuzumab and hyaluronidase-oysk	Cardiomyopathy, pulmonary toxicity, embryo-toxicity
traZODone	Suicidal ideation
tretinoin	Acute promyelocytic leukemia; experienced physician
triamterene	Hyperkalemia
triamterene-hydroCHLOROthiazide	Hyperkalemia
triazolam	Risk From Concomitant Use With Opioids
trifluoperazine	Elderly patients with dementia related psychosis
trimipramine	Suicidal ideation
trovafloxacin	Hepatotoxicity
umeclidinium-vilanterol	Vilanterol: Asthma-related death
upadacitinib	Serious Infections, Mortality, Malignancy, Major Adverse Cardiovascular Events (Mace), and Thrombosis
vadadustat	Increased Risk of Death, Myocardial Infarction (MI), Stroke, Venous Thromboembolism, and Thrombosis of Vascular Access
valbenazine	Depression and Suicidal Ideation and Behavior in Patients with Huntington’s Disease
valGANciclovir	Granulocytopenia, Anemia, Thrombocytopenia
valproic acid	Hepatotoxicity; Fetal Risk; Pancreatitis
valsartan	Fetal Toxicity
valsartan-hydroCHLOROthiazide	Valsartan: pregnancy risk
vancomycin	Risk of Embryo-Fetal Toxicity Due to Excipients
vandetanib	QT Prolongation, Torsades De Pointes, and Sudden Death
venetoclax	Tumor Lysis Syndrome
venlafaxine	Suicidal ideation
vigabatrin	Monitoring of Vision: Vision Testing
vilazodone	Suicidal ideation
viloxazine	Suicidal Thoughts and Behaviors
vinBLAStine	IV use only; granulocytopenia; avoid extravasation
vinCRIStine	IV use only; granulocytopenia; avoid extravasation
vinCRIStine liposome	IV use only; dose liposomal product differently
vinorelbine	IV use only; granulocytopenia; avoid extravasation
vismodegib	Embryo-Fetal Death and Severe Birth Defects
Voclosporin	Malignancies and Serious Infections
vortioxetine	Suicidal Ideation
warfarin	Serious bleeding risk
zaleplon	Complex Sleep Behaviors
ziconotide	Severe psychiatric symptoms, neurological impairment
zidovudine	Hematological adverse events; myopathy; lactic acidosis; hepatomegaly
ziprasidone	Mortality in elderly with dementia related psychosis
zolpidem	Complex Sleep Behaviors
zuranolone	Impaired Ability to Drive or Engage in Other Potentially Hazardous Activities

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