Approved Hospital Formulary
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Approved Hospital Formulary
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prothrombin complex
prothrombin complex
- Restricted Miscellaneous Programs
- Restricted Kcentra --> restricted to use for life-threatening bleeding or no sub. See below for approved prescribers.
Last updated: Sep. 14, 2021
- Therapeutic Interchange
- Black Box Warning: Arterial and venous thromboembolic complications
Dosing guidelines for emergent reversal of oral anticoagulants
FEIBA is the PREFERRED prothrombin complex concentrate (PCC) product for emergent reversal of oral anticoagulants.
Interchange orders from Kcentra to FEIBA unless no sub or contraindications exist. FEIBA
Approved Kcentra prescribers:
cardiologists, cardiovasular surgeons, emergency department physicians, hematologists, neurologists, neurosurgeons, vascular surgeons, and trauma surgeons.
Kcentra uses NOT related to oral anticoagulant bleeding:
Kcentra is the preferred PCC formulary product to be used for life threatening bleeding not related to oral anticoagulants.
Round doses of Kcentra to nearest 500 units.
Reviewed: August 27, 2013, and 28 March 2017, and 25 April 2017, and 28 Aug 2018