FormWeb • canagliflozin-metFORMIN

Huntsville Hospital

Approved Hospital Formulary

Suggestions or Corrections? Above and Beyond Nominations Formulary Request

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Medications not yet evaluated by P&T are considered NON-FORMULARY . . . . . Always check 2 unique patient identifiers - NAME and DATE OF BIRTH - at every step! . . . . . Please be sure to document all clinical activities daily.

Huntsville Hospital

Approved Hospital Formulary

Suggestions or Corrections? Above and Beyond Nominations Formulary Request

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canagliflozin-metFORMIN

canagliflozin-metFORMIN

Non-formulary Miscellaneous Program Formulary
Therapeutic Interchange

Drug Name	Form	Strength	Formulary Unrestricted	Formulary Restricted	Non-Formulary	Interchange
Invokamet XR	TABLET, EXTENDED RELEASE, ORAL	50 mg-500 mg, 150 mg-500 mg, 50 mg-1000 mg, 150 mg-1000 mg
Invokamet	TABLET, ORAL	50 mg-1000 mg, 50 mg-500 mg, 150 mg-1000 mg, 150 mg-500 mg

Comments:

ORDERED FORMULATION

THERAPEUTIC INTERCHANGE

canagliflozin-metFORMIN (Invokamet)

50 mg-1,000 mg tablet BID
50 mg-500 mg tablet BID
150 mg-1,000 mg tablet BID
150 mg-500 mg tablet BID

canagliflozin (Invokana) AND metFORMIN (Glucophage XR)

ONE 100 mg canagliflozin PLUS TWO 1,000 mg metFORMIN ER tablets (Total:2,000 mg) ONCE Daily
ONE 100 mg canagliflozin PLUS ONE 1,000 mg metFORMIN ER tablet ONCE Daily
ONE 300 mg canagliflozin PLUS TWO 1,000 mg metFORMIN ER tablets (Total:2,000 mg) ONCE Daily
ONE 300 mg canagliflozin PLUS ONE 1,000 mg metFORMIN ER tablet ONCE Daily

canagliflozin-metFORMIN (Invokamet XR)

50 mg-500 mg 2 tablets once daily
50 mg-1,000 mg 2 tablets daily
150 mg-500 mg 2 tablets daily
150 mg-1,000 mg 2 tablets daily

canagliflozin (Invokana) AND metFORMIN (Glucophage XR)

ONE 100 mg canagliflozin tablet plus TWO 500 mg metFORMIN ER tablets (Total: 1,000 mg) ONCE Daily
ONE 100 mg canagliflozin tablet plus FOUR 500 mg metFORMIN ER tablets (Total: 2,000 mg) ONCE Daily
ONE 300 mg canagliflozin tablet plus TWO 500 mg metFORMIN ER tablets (Total: 1,000 mg) ONCE Daily
ONE 300 mg canagliflozin tablet plus FOUR 500 mg metFORMIN ER tablets (Total: 2,000 mg) ONCE Daily

Invokamet medication guide

Invokamet XR medication guide

metFORMIN -- hold for 48 hours post IV contrast media per radiologist, contraindications with CHF, renal disease, hepatic disease, and age. Pharmacist may order SCr.

INVOKAMET is classified as non-formulary, not stocked. Dispense the individual components separately.

Reviewed: 24 February 2015 (Invokamet), and 25 April 2017 (Invokamet XR)

Last updated: Dec. 27, 2017

Black Box Warning: metFORMIN: Lactic Acidosis
Black Box Warning: canagliflozin: Lower Limb Ampution

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