Medications not yet evaluated by P&T are considered NON-FORMULARY. Always check 2 unique patient identifiers - NAME and DATE OF BIRTH - at every step! Please be sure to document all clinical activities daily.
The Ambrisentan REMS programs are no longer in effect as of April 2025.
Discharge Prescription Considerations
Ambrisentan is only available through specialty pharmacies. For a New Start (male or female), HH Pharmacy may send the patient home with a max 15 day supply of drug. Work closely with the prescribing physician and patient to determine when the specialty pharmacy will deliver first maintenance supply of drug.
Reviewed: September 23, 2008
Updated: May 2019 (REMS confirmation instructions), June 2020 (Interchange with Opsumit), May 2025 (REMS update)
Non-Formulary. Automatic interchange.
ORDERED FORMULATION
THERAPEUTIC INTERCHANGE
ambrisentan (Letairis)
macitentan(Opsumit)
The Ambrisentan REMS programs are no longer in effect as of April 2025.
Discharge Prescription Considerations
Reviewed: September 23, 2008
Updated: May 2019 (REMS confirmation instructions), June 2020 (Interchange with Opsumit), May 2025 (REMS update)