The Ambrisentan REMS programs are no longer in effect as of April 2025.
Discharge Prescription Considerations
Ambrisentan is only available through specialty pharmacies. For a New Start (male or female), HH Pharmacy may send the patient home with a max 15 day supply of drug. Work closely with the prescribing physician and patient to determine when the specialty pharmacy will deliver first maintenance supply of drug.
Reviewed: September 23, 2008
Updated: May 2019 (REMS confirmation instructions), June 2020 (Interchange with Opsumit), May 2025 (REMS update)
Letairis medication guide
Non-Formulary. Automatic interchange.
ORDERED FORMULATION
THERAPEUTIC INTERCHANGE
ambrisentan (Letairis)
macitentan(Opsumit)
The Ambrisentan REMS programs are no longer in effect as of April 2025.
Discharge Prescription Considerations
Reviewed: September 23, 2008
Updated: May 2019 (REMS confirmation instructions), June 2020 (Interchange with Opsumit), May 2025 (REMS update)