Tysabri or Tyruko are classified as formulary, restricted to neurologist (multiple sclerosis) and gastroenterologist (Crohn's disease) use in Outpatient Medical per REMS directives. Distribution is limited to the 'TOUCH' (Tysabri) or  Tyruko monitoring programs. Tyruko is therapeutically equivalent to Tysabri to be interchangeable for the approved FDA indications; the most cost-effective product should be used.

Inpatient cases should be rare and will be evaluated on a case by case basis.

Tysabri medication guide

The "Q" pharmacists and central pharmacy staff (on the weekends) are now responsible for verification of Tysabri orders for Outpatient Medical (OPM). It is no longer necessary for PSP to retain documentation containing the medication LOT # upon dispensing to comply with the TOUCH Prescribing Program. Please confirm the following items are completed and faxed to HCS:

1) Pre-Infusion Checklist (make sure patient has answered "NO" to all pre-infusion questions; if any are "YES" OPM must contact MD before verification)
2) Patient Authorization for current date (must be renewed by MD every 6 months)
3) Order/Prescription
4) Home med sheet (to check for immune suppressing medications; if found please contact OPM & MD for approval before verification)

Reviewed: October 25, 2006 (Tysabri), Jan 2024 (Tyruko)

REMS (Tysabri): View FDA REMS Info

• Micromedex
• UpToDate
• Lippincott Advisor