Alvimopan (Entereg) Protocol - Recommend discontinuation to prescriber after patient's first bowel movement. Automatic stop after a total of 15 doses (7 days), or at the time of discharge, whichever occurs first.
Alvimopan is for short term hospital use only and limited to a total of 15 doses (14 doses post-op), should not be used in outpatient setting.
Drug Transfer to Another Hospital - Alvimopan should not be transferred to any other hospital that is not alvimopan REMS certified.
Alvimopan – Formulary restricted to patients with partial large/small bowel disease undergoing bowel resection, or patients undergoing radical cystectomy restricted to physicians who are abdominal surgeons, gastroenterologists, or urologists approved in the REMS program per HH physician specific education (see REMS program approved physicians under Rx for Nursing or Rx for Physicians).
Reviewed: September 23, 2008 and 28 Feb 2017 (discontinuation rules)
Updated: June 2021 (automatic discontinuation discontinued)
Alvimopan (Entereg) Protocol - Recommend discontinuation to prescriber after patient's first bowel movement. Automatic stop after a total of 15 doses (7 days), or at the time of discharge, whichever occurs first.
Alvimopan is for short term hospital use only and limited to a total of 15 doses (14 doses post-op), should not be used in outpatient setting.
Alvimopan REMS Approved Prescriber List
Alvimopan – Formulary restricted to patients with partial large/small bowel disease undergoing bowel resection, or patients undergoing radical cystectomy restricted to physicians who are abdominal surgeons, gastroenterologists, or urologists approved in the REMS program per HH physician specific education (see REMS program approved physicians under Rx for Nursing or Rx for Physicians).
Reviewed: September 23, 2008 and 28 Feb 2017 (discontinuation rules)
Updated: June 2021 (automatic discontinuation discontinued)
REMS: View FDA REMS Info