Xgeva and Prolia are restricted to outpatient areas.
Inpatient consideration, denosumab use in hypercalcemia urgency (not hypercalcemia of malignancy): - Currently, little reliable information is available regarding the use of denosumab for hypercalcemia urgency related to parathyroid hormone abnormality. This medication is relatively long acting, so clinical response could be delayed (up to a week or longer for time to response and complete response seen out to 3+ weeks). There is currently no criteria set or protocol for using denosumab in hypercalcemia urgency at Huntsville Hospital; use should be evaluated on a case by case basis.(Drug Info statement December 2022)
Reviewed: August 24, 2010 (Prolia) and March 22, 2011 (Xgeva)
Prolia medication guide
Xgeva and Prolia are restricted to outpatient areas.
Inpatient consideration, denosumab use in hypercalcemia urgency (not hypercalcemia of malignancy): - Currently, little reliable information is available regarding the use of denosumab for hypercalcemia urgency related to parathyroid hormone abnormality. This medication is relatively long acting, so clinical response could be delayed (up to a week or longer for time to response and complete response seen out to 3+ weeks). There is currently no criteria set or protocol for using denosumab in hypercalcemia urgency at Huntsville Hospital; use should be evaluated on a case by case basis. (Drug Info statement December 2022)
Reviewed: August 24, 2010 (Prolia) and March 22, 2011 (Xgeva)
REMS (Prolia): View FDA REMS Info