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Black Box Warnings

Please review each of these drugs carefully.

abacavir	Hypersensitivity
acetaminophen	Hepatotoxicity
acetaminophen-butalbital-caffeine	acetaminophen: Hepatotoxicity
acetaminophen-codeine	codeine: Addiction, Abuse, And Misuse; Life-Threatening Respiratory Depression; Risks From Concomitant Use With Benzodiazepines acetaminophen: Hepatotoxity
acetaminophen-diphenhydrAMINE	acetaminophen: Hepatotoxicity
acetaminophen-HYDROcodone	Serious and Life-Threatening Risks from Use of Hydrocodone and Acetaminophen Products
acetaminophen-oxyCODONE	acetaminophen: hepatotoxicity oxyCODONE: Addition, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; and Hepatotoxicity
acetaminophen-traMADol	acetaminophen: Hepatotoxicity
acitretin	Pregnancy/Teratogenecity
adalimumab	Serious Infections and Malignancy
ado-trastuzumab emtansine	Hepatotoxicity, Cardiac Toxicity, Embryo-Fetal Toxicity
aldesleukin	Capillary Leak Syndrome
alemtuzumab	Hematological toxicity; opportunistic infections
aliskiren	Pregnancy risk
alogliptin-metFORMIN	metFORMIN: Lactic Acidosis
ALPRAZolam	Risks From Concomitant Use in Opioids
Alprostadil	Apnea
alvimopan	Short-term hospital use only
ambrisentan	Hepatic Injury; pregnancy risk; restricted distribution
amikacin	Neurotoxicity; nephrotoxicity
aMILoride	Hyperkalemia
amiodarone	Oral: Pneumonitis; Proarrhythmic Effects
amitriptyline	Suicidal ideation in children, adolescents
amphetamine-dextroamphetamine	Abuse/diversion potential; drug dependence
amphotericin B	Noninvasive fungal disease; avoid overdose
apixaban	Discontinuation without anticoagulation
arformoterol	Asthma Related Death
ARIPiprazole	Elderly patients with dementia related psychosis
arsenic trioxide	Cardiac toxicity
asparaginase Escherichia coli	Anaphylaxis; sudden death
bacitracin	Injection: Nephrotoxicity
baclofen	Intrathecal: Abrupt discontinuation
bamlanivimab	Limitations of Authorized Use for COVID-19
baricitinib	Serious Infections, Mortality, Malignancy, Major Adverse Cardiovascular Events (MACE), and Thrombosis
belatacept	Post transplant lymphoproliferative disorder; serious infections
benazepril	ACE inhibitor pregnancy risk
benzathine penicillin-procaine penicillin	Not for Intravenous Use
bexarotene	Contraindication in Pregnancy
bleomycin	Pulmonary Fibrosis; Idiosyncratic Reactions
blinatumomab	Cytokine Release Syndrome and Neurological Toxicities
bosentan	Hepatotoxicity; teratogenecity
BRENtuximab vedotin	Progressive Multifocal Leukoencephalopathy (PML)
budesonide-formoterol	Asthma Related Death
bumetanide	Potent diuretic
BUPivacaine	Intravascular Injection Risk (0.75% strength caution); Risk of Cardiac Arrest with Use in Obstetrical Anesthesia
BUPivacaine-fentaNYL	fentaNYL: Serious adverse events, deaths; abuse potential
buprenorphine	Addiction, Abuse, And Misuse; Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; Risks From Concomitant Use With Benzodiazepines
buprenorphine-naloxone	Addiction, Abuse, And Misuse; Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; Risks From Concomitant Use With Benzodiazepines
buPROPion	Suicidal Ideation
busulfan	Bone marrow suppression
butorphanol	Addiction, Abuse, And Misuse; Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; and Risks From Concomitant Use With Benzodiazepines
cabazitaxel	Hemtalogical & Hypersensitivity Reactions
caffeine-ergotamine	Drug interaction risk
candesartan	Pregnancy risk
capecitabine	Warfarin Interaction
captopril	Pregnancy risk
captopril-hydroCHLOROthiazide	captopril: Pregnancy risk
carBAMazepine	Hematological Risk; Serious Dermatologic Reactions
carbidopa-levodopa	Bolded (not boxed): Carbidopa dosing
CARBOplatin	Myelosuppression; Anaphylaxis risk
carfilzomib	Cardiac Toxicities; Tumor Lysis Syndrome; Pumonary Toxicity; Dyspnea; Hyprertension
carmustine	Bone Marrow Suppression; Pulmonary Toxicity
celecoxib	Cardiovascular, gastrointestinal risk
cetuximab	Infusion Reactions; Cardiopulmonary Arrest
chlorambucil	Bone marrow suppression; teratogen
chloramphenicol	Fatal blood dyscrasias
chlordiazePOXIDE	Risks From Concomitant Use With Opioids
chlorproMAZINE	Mortality in elderly with dementia
cidofovir	Nephrotoxicity; neutropenia
cilostazol	CHF patient contraindication
ciprofloxacin	Tendinitis; tendon rupture
CISplatin	Nephrotoxicity; Myelosuppression
citalopram	Suicidal Thoughts and Behaviors
cladribine	Bone Marrow Suppression; Neurotoxicity; Nephrotoxicity
clindamycin	Pseudomembranous colitis
cloBAZam	Risk From Concomitant Use with Opiods
clonazePAM	Risk From Concomitant Use With Opioids
cloNIDine	Epidural cloNIDine
clopidogrel	Poor CYP2C19 metabolizers
clorazepate	Risks From Concomitant Use With Opioids
cloZAPine	Agranulocytosis, myocarditis, seizure risk
codeine	Addiction, Abuse, And Misuse; Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; and Risks From Concomitant Use With Benzodiazepines
conjugated estrogens IV	Endometrial cancer; cardiovascular; dementia risk
conjugated estrogens PO	Endometrial cancer; cardiovascular; dementia risk
conjugated estrogens topical	Endometrial cancer; cardiovascular; dementia risk
cycloSPORINE IV	Infection, neoplasm, nephrotoxicity risk
cycloSPORINE PO	Infection, neoplasm, nephrotoxicity risk
cytarabine	Prior to initiation of therapy
dabigatran	Discontinuation without anticoagulation
dacarbazine	Hemopoietic depression; hepatic necrosis risk
DACTINomycin	Handling precautions; extravasation risk
danazol	Pregnancy Contraindication; Stroke Risks; Benign Intracranial Hypertension
dantrolene	Hepatotoxicity
darbepoetin alfa	ESAs Increase The Risk Of Death, Myocardial Infarction, Stroke, Venous Thromboembolism, Thrombosis Of Vascular Access And Tumor Progression Or Recurrence
DAUNOrubicin	Cardiac, myelosuppression, extravasation risk
deferiprone	Agranulocytosis; Neutropenia
demo	Cardiovascular; gastrointestinal risk
denosumab	Severe Hypocalcemia in Patients with Advanced Kidney Dise, Severe Hypocalcemia and Mineral Metabolism Changes
desvenlafaxine	Suicidal ideation
diatrizoate	Not for intrathecal use
diazePAM	Risks From Concomitant Use With Opioids
diclofenac	Cardiovascular, gastrointestinal risk
didanosine	Pancreatitis, hepatotoxicity, lactic acidosis risk
dihydroergotamine	Drug interaction risk
disopyramide	Mortality Risk
DOCEtaxel	Hepatic dysfunction, hypersensitivity risk
dofetilide	Initiation or re-initiation monitoring
DOPamine	Peripheral ischemia risk
doxepin	Suicidal Ideation
DOXOrubicin	Cardiac, hepatic, myelosuppression, extravasation risk
DOXOrubicin liposomal	Cardiac, acute infusion reaction, myelosuppresssion risk
dronedarone	Contraindication in certain CHF conditions
droPERidol	QT prolongation; cardiac risk
DULoxetine	Suicidal Ideation
edetate calcium disodium	Lead encephalopathy risk
emtricitabine	Lactic Acidosis, Severe Hepatomegaly
emtricitabine-tenofovir	Lactic Acidosis/Severe Hepatomegaly with Steatosis, Post Treatment Acute Exacerbation of Hepatitis B, and Risk of Drug Resistance with Use of TRUVADA for Pre-Exposure Prophylaxis (PrEP) in Undiagnosed Early HIV-1 Infection
enalapril	Pregnancy risk
enfortumab vedotin	Serious Skin Reactions
enoxaparin	Spinal/epidural hematoma risk
entecavir	Lactic acidosis, severe hepatomegaly; hepB co-infection
epiRUBicin	Cardiac Toxicity, Secondary Malignancies, Extravasation & Tissue Necrosis, and Severe Myelosuppression
epoetin alfa	ESAs Increase The Risk Of Death, Myocardial Infarction, Stroke, Venous Thromboembolism, Thrombosis Of Vascular Access And Tumor Progression Or Recurrence
escitalopram	Suicidal Thoughts and Behaviors
estazolam	Risks From Concomitant Use With Opioids
esterified estrogens	Endometrial cancer; cardiovascular; dementia risk
esterified estrogens-methylTESTOSTERone	estrogen: Endometrial cancer; cardiovascular; dementia risk
estradiol	Oral: endometrial cancer; cardiovascular; dementia risk
estradiol IM	Estrogens Increase The Risk of Endometrial Cancer
estradiol patch	Transdermal: endometrial cancer; cardiovascular; dementia risk
estradiol vaginal	Estrogens Increase The Risk of Endometrial Cancer
eszopiclone	Risk of Serious Injuries With Certain Prescription Insomnia Medications
ethacrynic acid	Potent Diuretic
ethinyl estradiol-norethindrone	Cardiovascular and Other Risks
etodolac	Cardiovascular; gastrointestinal risk
etoposide	Myelosuppression risk
everolimus	Malignancies and Serious Infections, Nephrotoxicity, Kidney Graft Thrombosis, Mortality in Heart Transplantation
exenatide	Extended Release Injection: Risk of thyroid c-cell tumors
factor VIIa, recombinant	Serious Thrombotic Adverse Events Associated with Recombinant Coagulation Factor VIIa Outside Label Indicatons
fat emulsion, intravenous	Cautious use in infants Death in preterm infants
febuxostat	Cardiovascular Death
fentaNYL	Serious Adverse Events, Deaths; Abuse and Risk of Overdose; Do Not Substitute; Nasal Spray: Schedule II Controlled Substance: Abuse potential Sublingual Spray: Risk of respiratory depression, medication errors, abuse potential Transdermal: High concentration of Schedule II opioid agonist
ferric carboxymaltose	Iron Overdose Risk
ferrous fumarate	Iron Overdose Risk
ferrous gluconate	Iron Overdose Risk
ferrous sulfate	Iron Overdose Risk
ferumoxytol	Iron Overdose Risk Risk For Serious Hypersensitivity/Anaphylaxis Reactions
flecainide	Cardiovascular risk
floxuridine	Hematological risk
flucytosine	Hepatic, hematologic risks; caution in renal impairment
fludarabine	Neurotoxicity, hemolytic anemia risk
flumazenil	Seizure Risk
FLUoxetine	Suicidal Ideation
fluPHENAZine	Mortality in elderly with dementia
flurazepam	Risks From Concomitant Use With Opioids
flutamide	Hepatotoxicity
fluticasone-salmeterol	Salmeterol: asthma related death; pediatric and adolescent patients
fluvoxaMINE	Suicidal Ideation
fondaparinux	Spinal/epidural hematoma risk
foscarnet	Nephrotoxicity; seizure risk
fosinopril	Pregnancy risk
fosphenytoin	Cardiovascular risk with rapid infusion
furosemide	Potent Diuretic
ganciclovir IV	Hematological toxicity; IV and oral different indications
gemtuzumab ozogamicin	Hematological, Hepatotoxicity, Anaphlyaxis; use as single agent
gentamicin	Ototoxicity; Nephrotoxocity
glyBURIDE-metFORMIN	metFORMIN: Lactic Acidosis
glycopyrrolate-indacaterol	Asthma-related death
golimumab	Risk of Serious Infections, Malignancy in Children and Adolescents
haloperidol	Mortality in elderly with dementia
hemin	Use only after alternate therapy failure
heparin	Spinal/Epidural Hematomas
hydroCHLOROthiazide-methyldopa	Individualize dose
hydroCHLOROthiazide-triamterene	Hyperkalemia
hydroCHLOROthiazide-valsartan	Valsartan: ACE inhibitor pregnancy risk
HYDROmorphone	Injection: Respiratory depression risk; abuse potential Injection, High Potency: Opioid-tolerant patients only; Respiratory depression risk; abuse potential Oral, extended release: Opioid-tolerant patients only; overdose risk; abuse potential Oral: Abuse potential; respiratory depression; neonatal withdrawal; alcohol interaction
hydroxychloroquine	Prior to initiation of therapy
hydroxyurea	Prior to initiation of therapy
ibuprofen	Cardiovascular; gastrointestinal risk
ibutilide	Potentially Fatal Arrhythmias
IDArubicin	Cardiotoxicity; myelosuppression; renal/hepatic impairment; avoid extravasation
ifosfamide	Urotoxicity; myelosuppressionm CNS toxicity
imipramine	Suicidal ideation
immune globulin intramuscular	Renal dysfunction, acute renal failure
immune globulin intravenous	Renal dysfunction, acute renal failure
immune globulin intravenous and subcutaneous	Renal dysfunction, acute renal failure
indacaterol	Asthma Related Death
indomethacin	Cardiovascular; gastrointestinal risk
inFLIXimab	Serious infection risk; hepatosplenic t-cell lymphomas; malignancy
inotuzumab ozogamicin	Hepatotoxicity, Increased Risk of Post-Hematopoietic Stem Cell, Transplant Non-Relapse Mortality
interferon alfa-2b	Neuropsychiatric, autoimmune, ischemic and infectious disorders
ipilimumab	Immune-Mediated Adverse Reactions
irbesartan	ACE inhibitor pregnancy risk
irinotecan	Severe diarrhea
iron dextran	Injection: Anaphylactic reaction risk
iron polysaccharide	Iron overdose risk
iron sucrose	Iron overdose risk
ISOtretinoin	Pregnancy contraindication
ixabepilone	Toxicity in hepatic impariment
ketamine	Emergence reactions; psychological manifestations
ketoprofen	Cardiovascular; gastrointestinal risk
ketorolac	Duration of therapy; max dose; GI, cardiovascular, bleeding, renal risk
lamiVUDine	Lactic acidosis, hepatomegaly; exacerbations of hepatitis b; dosing formulation
lamiVUDine-zidovudine	lamiVUDine: Lactic acidosis, hepatomegaly; exacerbations of hepatitis b; dosing formulation Zidovudine: Hematological adverse events; myopathy; lactic acidosis; hepatomegaly
lamoTRIgine	Serious dermatological reactions
lapatinib	Hepatotoxicity
leflunomide	Pregnancy risk
lenalidomide	Embryo-Fetal Toxicity and Restricted Distribution Program, Hematologic Toxicity, Venous Thromboembolism
levoFLOXacin	Tendinitis, tendon rupture; Pediatric Use
levonorgestrel	Bolded (not boxed): Not Protective Against HIV
levothyroxine	Treatment of obesity or weight loss
lidocaine topical	Lidocaine, viscous: Do NOT use for teething pain
linaCLOtide	Risk of Serious Dehydration in Pediatric Patients
lindane topical	Neurotoxicity
liothyronine	Treatment of obesity or weight loss
lisinopril	ACE inhibitor pregnancy risk
lithium	Monitoring recommendations
lomustine	Bone marrow suppression
lopinavir-ritonavir	ritonavir: Drug interactions
LORazepam	Risks From Concomitant Use With Opioids
losartan	Pregnancy risk
loxapine	Elderly patients with dementia related psychosis Aerosol: Bronchospasm
lurasidone	Mortality in elderly patients with dementia related psychosis
macitentan	Embryo-Fetal Toxicity
mannitol	Severe bronchospasm risk
mechlorethamine	Prior to initiation of therapy
medroxyPROGESTERone IM	Injection: Loss of Bone Mineral Density
medroxyPROGESTERone PO	Cardiovascular Disorders, Breast Cancer and Probable Dementia for Estrogen Plus Progestin Therapy
meloxicam	Cardiovascular; gastrointestinal risk
melphalan PO	Bone marrow suppression; hypersensitivity reactions; pregnancy risk
meperidine	Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome
mercaptopurine	Bolded (not boxed): initiation of therapy
metFORMIN	Lactic Acidosis
metFORMIN-pioglitazone	metFORMIN: Lactic Acidosis pioglitazone: Congestive heart failure
metFORMIN-repaglinide	metFORMIN: Lactic Acidosis
metFORMIN-rosiglitazone	metFORMIN: Lactic Acidosis
metFORMIN-sAXagliptin	metFORMIN: Lactic Acidosis
metFORMIN-SITagliptin	metFORMIN: Lactic Acidosis
methacholine	Diagnostic Use Only; Severe Bronchoconstriction
methadone	Risk during initiation of or conversion to methadone
methohexital	Continuous monitoring of respiratory and cardiac function
methotrexate IV	Bone marrow, liver, lung and kidney toxicity risk
methotrexate PO	Bone marrow, liver, lung and kidney toxicity risk
methylene blue	Serotonin Syndrome with Concomitant Use of Serotonergic Drugs
methylphenidate	Tolerance and dependence
metoclopramide	Tardive Dyskinesia
metOLazone	Bolded (not boxed): do not interchange
metroNIDAZOLE	Carcinogenicity
mexiletine	Mortality; Acute Liver Injury
midazolam	Risk From Concomitant Use With Opiods; Individualize dose
midodrine	Supine blood pressure > 180 mmHg
miFEPRIStone	Serious and sometimes fatal infections and bleeding occur very rarely following spontaneous, surgical and medical abortions
miltefosine	Embryo-Fetal Toxicity
minoxidil	Antihypertensive risk
mirtazapine	Suicidal ideation
mirvetuximab soravtansine	Ocular Toxicity
miSOPROStol	Pregnancy risk
mitoMYcin	Bone marrow suppression; hemolytic uremic syndrome
mitotane	Temporarily stop therapy after shock or severe trauma because drug's prime action is adrenal suppression.
mitoXANTRONE	Cardiotoxicity; baseline neutrophil count; extravasation risk
moexipril	ACE inhibitor pregnancy risk
montelukast	Serious Neuropsychiatric Events
morphine	24-hour observation following epidural/intrathecal administration Controlled/Extended Release: Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome
moxifloxacin	Tendinitis, tendon rupture
multivitamin with iron	Iron overdose risk
mycophenolate mofetil IV	Embryofetal Toxicity, Malignancies, and Serious Infections
mycophenolate mofetil PO (Capsule)	Embryofetal Toxicity, Malignancies, and Serious Infections
mycophenolate mofetil PO (suspension)	Embryofetal Toxicity, Malignancies, and Serious Infections
mycophenolic acid	Embryofetal Toxicity, Malignancies, and Serious Infections
nabumetone	Cardiovascular; gastrointestinal risk
nalbuphine	Life-Threatening Respiratory Depression
naloxone-pentazocine	pentazocine: Addiction, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome
naproxen	Cardiovascular; gastrointestinal risk
nefazodone	Hepatotoxicity
nelarabine	Prior to initiation of therapy; neurologic events
neomycin	Neurotoxicity, nephrotoxicity, ototoxicity; general toxicity
nevirapine	Hepatotoxicity; dermal reactions; patient monitoring
nilotinib	QT Prolongation and Sudden Death
niMODipine	Serious harm with IV administration of oral product
nitroprusside	Cyanide toxicity; hypotension risk; dilute
norEPINEPHrine	Extravasation risk
nortriptyline	Suicidal ideation
OLANZapine	Mortality in elderly with dementia related psychosis
olmesartan	ACE inhibitor pregnancy risk
omalizumab	Anaphylaxis
onabotulinumtoxinA	Distant spread of toxin effect
oprelvekin	Allergic reactions, including anaphylaxis
ospemifene	Endometrial Cancer/Cardiovascular Disorders
OXALIplatin	Anaphylactic-like reactions
oxazepam	Risks From Concomitant Use With Opioids
oxyCODONE	Oral solution: Risk of errors Controlled release: Abuse potential
oxyMORphone	Abuse/diversion potential; drug dependence
oxytocin	Elective induction of labor
PACLitaxel	Prior to initiation of therapy
PACLitaxel protein-bound particles	Prior to initiation of therapy
PARoxetine	Suicidal ideation
PAZOPanib	Severe and fatal hepatotoxicity has been observed in clinical studies.
pentetate calcium trisodium	Asthma Exacerbation with Nebulization and Depletion of Trace Metals During Therapy
pentostatin	Prior to initiation of therapy
perflutren	Serious cardiopulmonary reactions
perindopril	ACE inhibitor pregnancy risk
pertuzumab	Cardiomyopathy and Embryo-Fetal Toxicity
phenylephrine	Prior to initiation of therapy
phenytoin IV	Cardiovascular risk with rapid infusion
phytonadione	Severe reactions with IM and IV use
pioglitazone	Congestive heart failure
piroxicam	Cardiovascular; gastrointestinal risk
pomalidomide	Embryo-Fetal Toxicity And Venous And Arterial Thromboembolism
PONATinib	Arterial Occlusive Events, Venous Thromboembolic Events, Heart Failure, and Hepatotoxicity
prasugrel	Bleeding risk
primaquine	Prior to initiation of therapy
procainamide	Positive titers with chronic administration
procarbazine	Prior to initiation of therapy
prochlorperazine	Elderly patients with dementia related psychosis
progesterone	Cardiovascular disorders; breast cancer; probable dementia
promethazine	Patients < 2 years; severe tissue injury
propafenone	Mortality (CAST trial results)
propylthiouracil	Severe liver injury; acute liver failure
protamine	Hypotension, pulmonary hypertension; risk factors described
prothrombin complex	Arterial and venous thromboembolic complications
quazepam	Risks From Concomitant Use With Opioids
QUEtiapine	Elderly patients with dementia related psychosis
quinapril	ACE inhibitor pregnancy risk
quiNINE	No benefit in leg cramps; hematologic risks
raloxifene	Risk of VTE and death from stroke
ramipril	Olmesartan: ACE inhibitor pregnancy risk
rasburicase	Anaphylaxis; hemolysis; methemoglobinemia; uric acid measure interference
regorafenib	Hepatotoxicity
remdesivir	Black Box Warning is for Use of Remdesivir to Treat COVID-19.
reslizumab	Anaphylaxis
ribavirin	Oral: Monotherapy; hemolytic anemia; teratogenicity Inhalation: Respiratory function deterioration
riociguat	Embryo-Fetal Toxicity
risperiDONE	Elderly patients with dementia related psychosis
ritonavir	Drug interaction risk
riTUXimab	Fatal infusion reaction; mucocutaneous reactions; progressive multifocal leukoencephalopathy; hep b reactivation
rivaroxaban	Premature discontinuation; spinal/epidural hematomas
rocuronium	Prior to initiation of therapy
ROPivacaine-SUFentanil	SUFentanil: Addition, Abuse, and Misuse
rosiglitazone	Thiazolidinediones, including pioglitazone and rosiglitazone, cause or exacerbate congestive heart failure in some patients.
sacituzumab govitecan	Neutropenia and Diarrhea
sacubitril-valsartan	valsartan: Fetal Toxicity valsartan: Fetal Toxicity
salmeterol	Asthma Related Deaths
salsalate	Cardiovascular; gastrointestinal risk
sarilumab	Risk of Infections
sertraline	Suicidal ideation
sirolimus	Immunosuppression; liver or lung transplant patients
sodium phosphate	Phosphate nephropathy
sotalol	Therapy initiation; renal impairment caution; product selection
spironolactone	Possible tumorigen
stavudine	Pancreatitis, lactic acidosis, hepatomegaly
streptomycin	Neurotoxicity; nephrotoxicity
streptozocin	Nephrotoxicity; experienced physician; mutagen
succinylcholine	Hyperkalemic rhabdomyolysis in infants or children
SUFentanil	Addition, Abuse, and Misuse
sulindac	Cardiovascular; gastrointestinal risk
SUNItinib	Hepatotoxicity has been observed in clinical trials and post-marketing experience. This hepatotoxicity may be severe and deaths have been reported.
tacrolimus	Lymphoma risk; infection related to immunosuppression
tamoxifen	Women at high risk for breast cancer; women with DCIS
telavancin	Increased Mortality/Nephrotoxicity/Fetal Risk
telmisartan	ACE inhibitor pregnancy risk
temazepam	Risks From Concomitant Use With Opioids
teniposide	Myelosuppression; hypersensitivity reactions
tenofovir	Lactic acidosis, severe hepatomegaly; hepB co-infection
terbutaline	Preterm labor (injectable and oral)
teriflunomide	Hepatotoxicity and Embryofetal Toxicity
thalidomide	Embryo-Fetal Toxicity and Venous Thromboembolism
thioridazine	QTc prolongation; elderly with dementia related psychosis
thiothixene	Elderly patients with dementia related psychosis
thrombin topical	Bleeding, thrombosis risk
thyroid desiccated	Treatment of obesity or weight loss
ticagrelor	Bleeding Risk
ticlopidine	Severe hematological adverse events
tigecycline	All cause mortality
tisotumab vedotin	Ocular toxicity
tiZANidine	Bolded (not boxed): bioequivalence between products
tobramycin	Ototoxicity, nephrotoxicity risk with IV use
tocilizumab	Serious infections risk
tofacitinib	Serious Infections, Mortality, Malignancy, Major Adverse Cardiovascular Events (MACE), and Thrombosis
tolcapone	Hepatotoxicity
tolvaptan	Risk of Serious Liver Injury
topotecan	Bone marrow suppression
traMADol	Addiction, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; and Hepatotoxicity
trastuzumab	Cardiomyopathy; infusion reactions, pulmonary toxicity; teratogenicity
traZODone	Suicidal ideation
triazolam	Risks From Concomitant Use With Opioids
trifluoperazine	Elderly patients with dementia related psychosis
valGANciclovir	Hematologic Toxicity; Impairment of Fertility; Fetal Toxocity; Mutagenesis & Carcinogenesis
valproic acid IV	Risk to children exposed in utero
valproic acid PO	Risk to children exposed in utero
valsartan	ACE inhibitor pregnancy risk
vandetanib	QT Prolongation
venlafaxine	Suicidal ideation
vigabatrin	Permanent Vision Loss
vilazodone	Suicidal ideation
vinBLAStine	IV use only; granulocytopenia; avoid extravasation
vinCRIStine	IV use only; dose liposomal product differently
vinORELBine	IV use only; granulocytopenia; avoid extravasation
vismodegib	Embryo-Fetal Death and Severe Birth Defects
vortioxetine	Suicidal Thoughts and Behaviors
warfarin	Serious bleeding risk
zaleplon	Risk of Serious Injuries With Certain Prescription Insomnia Medications
zidovudine	Hematological adverse events; myopathy; lactic acidosis; hepatomegaly
ziprasidone IM	Mortality in elderly with dementia related psychosis
ziprasidone PO	Mortality in elderly with dementia related psychosis
zolpidem	Complex Sleep Behaviors

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

This site is intended for the staff of Iredell Health System. While others may view accessible pages, Iredell Health System makes no warranty, express or implied, as to the use of this information outside of Iredell Health System. The content of this policy and procedure document serves as guidance to the delivery of quality patient care. Care providers are expected to exercise critical thinking and situational awareness skills, and in specific situations to take such action as is necessary for the delivery of quality patient care.