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valproic acid PO

valproic acid PO

Brand names: Depakene, Depakote, Depakote ER, Depakote Sprinkles

Form	Strength
CAPSULE, ORAL	250 mg
DELAYED RELEASE CAPSULE, ORAL	125 mg
DELAYED RELEASE TABLET, ORAL	125 mg; 250 mg
SYRUP, ORAL	250 mg/5 mL
TABLET, EXTENDED RELEASE, ORAL	250 mg; 500 mg

Display Anticonvulsants, Miscellaneous Class: 281292

Medication comments:

USP <800> Hazardous Drug Assessment of Risk (AOR)
Per policy, these drugs are exempt from USP <800> handling requirements under normal circumstances. The following outlines must be followed.
generic (Brand) Route [Packaging: Mfg ⇒ Dispense]		NIOSH Group
valproic acid (Depakene, Depakote) PO [UD ⇒ UD]		Reproductive Risk
Pharmacy: Receiving / Storage / Preparation Exposure Risk: minimal	• Handling/preparation PPE Requirements: n/a
	• Receiving from Distributor: Standard
	• Pharmacy Storage Area: Carousel
	• Packaging/Reconstitution Location: n/a
	• Compounding (Non-Sterile/Sterile) Location: n/a
	• Omnicell Load: Yes
Transport	• Transport (dose is placed inside a plastic sealable bag): Standard
Nursing: Storage / Admin. Exposure Risk: low	• Handling/administration PPE Requirements: PO- Single CX gloves , tube- double CX gloves and gown , wash hands after handling
	• Storage of Finished dose in Nursing Area/Procedural Area: Patient Med Drawer, Omnicell
	• Signage on Patient Door Required: No
	• Manipulation of Dosage Form: Standard
	• Special Manipulation for Administration: n/a
Disposal / Spills	• Disposal of Drug Waste: Full- blue bin , trace/packaging- trash
	• Disposol of Used PPE: trash bin (inside plastic bag)
	• Spill management: n/a
NIOSH Supplemental Information: BBW for teratogenicity; congenital malformations, including neural tube defects; teratogenic in muliple species
Reason for exemption of USP<800> Containment Requirements: Purchased in final dosage form; packaged as unit dose. Does not require additional manipulation for dispensing.

Enteral Drug Administration notes.
Generic (Brand)	Comments and Considerations	Recommendations for Administration with Enteral Nutrition
valproic acid (Depacon, Depakote)	Administration with food may delay rate of absorption	Suggest administering same total daily dose, but use valproic acid solution dosed every 6-8 hours. Monitor levels.

Last updated: Jan. 23, 2023

Hazard.Drug Handling(USP 800) USP<800> Hazardous Drug / Assessment of Risk
Black Box Warnings Risk to children exposed in utero

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

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