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glyBURIDE-metFORMIN

glyBURIDE-metFORMIN

Brand names: Glucovance

Form	Strength
TABLET, ORAL	5 mg-500 mg

Display Biguanides, Sulfonylureas Class: 682004, 682020

Medication comments:

2023 American Geriatrics Society Beers Criteria^® for potentially inappropriate medication use in older adults.
Medication:	glyBURIDE (Diabeta, Glynase, Micronase)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Comments	aka glibenclamide
Drug(s)	sulfonylureas (all, including short- and longer-acting)
Rationale	Sulfonylureas have a higher risk of cardiovascular events, all-cause mortality, and hypoglycemia than alternative agents. Sulfonylureas may increase the risk of cardiovascular death and ischemic stroke. Among sulfonylureas, long-acting agents (e.g., glyBURIDE, glimepiride) confer a higher risk of prolonged hypoglycemia than short-acting agents (e.g., glipiZIDE).
Recommendation	Avoid sulfonylureas as first- or second-line monotherapy or add-on therapy unless there are substantial barriers to the use of safer and more effective agents. If a sulfonylurea is used, choose short-acting agents (e.g., glipiZIDE) over long-acting agents (e.g., glyBURIDE, glimepiride).
Quality of evidence: Hypoglycemia: High CV events and all-cause mortality: Moderate CV death and ischemic stroke: Low, Strength of Recommendation: Strong

Last updated: Sep. 19, 2025

Black Box Warnings metFORMIN: Lactic Acidosis

UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

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