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levoFLOXacin

levoFLOXacin

Brand names: Levaquin

Form	Strength
SOLUTION, INTRAVENOUS	250 mg/50 mL; 500 mg/100 mL
TABLET, ORAL	250 mg; 500 mg

Display Quinolones, Antituberculosis Agents Class: 081218, 081604

Medication comments:

Per policy, these drugs are subject to renal dosing adjustments by pharmacy.
Generic + Route (Brand) • Indications	Usual Adult Dose Comments	Renal Dosage Adjustments
levoFLOXacin PO/IV (Levaquin^©) • Healthcare-associated Pneumonia (HAP) (7-14 days) • Community-acquired Pneumonia (CAP) (5 days) • Cellulitis • Severe infection	750 mg q24h	CrCl ≥ 50: No adjustment necessary CrCl 20-50: 750 mg q48h CrCl < 20: 750 mg x1, then 500 mg q48h HD, intermittent (3x/week): 750 mg x 1 then EITHER 500 mg q48h OR 250 mg q24h
levoFLOXacin PO/IV (Levaquin^©) • Community-acquired pneumonia (7-14 days) • Other infections	500 mg q24h	CrCl ≥ 50: No adjustment necessary CrCl 20-50: 500 mg x1, then 250 mg q24h CrCl < 20: 500 mg x1, then 250 mg q48h HD, intermittent (3x/week): 500 mg x 1 then EITHER 250 mg q48h OR 125 mg q24h
levoFLOXacin PO/IV (Levaquin^©) • Uncomplicated UTI	250 mg q24h	CrCl ≥ 20: No adjustment necessary CrCl < 20: 250 mg q48h (unless uncomplicated UTI, where no adjustment is necessary) HD, intermittent (3x/week): 250 mg q48h

Per policy, these drugs may be converted from IV to PO in patients who meet criteria.
Generic (Brand)	Population	IV Dose	PO Dose	Notes
levoFLOXacin (Levaquin)	adult	500 mg IV q24h	500 mg PO q24h	Avoid concurrent divalent and trivalent cation administration 2 hours before or 6 hours after. Avoid administration with tube feeds.
	adult	750 mg IV q24h	750 mg PO q24h
	pediatric	<5 y/o: 10 mg/kg q12h, ≥5 y/o: 10 mg/kg q24h (max: 750 mg/day)	<5 y/o: 10 mg/kg q12h, ≥5 y/o: 10 mg/kg q24h (max: 750 mg/day)

Enteral Drug Administration notes.
Generic (Brand)	Comments and Considerations	Recommendations for Administration with Enteral Nutrition
levoFLOXacin (Levaquin)	Oral levoFLOXacin tablets with food prolongs Tmax by 1h and decreases Cmax by 14%. Oral solution with food decreased Cmax by 25%	Suggest changing to IV levoFLOXacin for severe infection. No dosing changes for oral tablet. For oral solution, consider holding tube feedings 1 hour before and 2 hours after.

Last updated: Apr. 23, 2024

Renal Adjustment Policy levoFLOXacin subject to adjustments by pharmacy.
IV to PO Conversion Policy Policy
Black Box Warnings Tendinitis, tendon rupture
Look-Alike/Sound-Alike levoFLOXacin confused with levETIRAcetam

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

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