Per policy, these drugs may be converted from IV to PO in patients who meet criteria.
Generic (Brand)
Population
IV Dose
PO Dose
Notes
ciprofloxacin (Cipro)
adult
200 mg IV q12h
250 mg PO q12h
Avoid concurrent divalent and trivalent cation administration 2 hours before or 6 hours after. Avoid administration with tube feeds.
200 mg IV q24h
250 mg PO q24h
400 mg IV q8h
750 mg PO q12h
400 mg IV q12h
500 mg PO q12h
400 mg IV q24h
500 mg PO q24h
pediatric
10-15 mg/kg q8-12h (max: 400 mg/dose or 40 mg/kg/day)
10-15 mg/kg q8-12h (max: 750 mg/dose or 40 mg/kg/day)
Enteral Drug Administration notes.
Generic (Brand)
Comments and Considerations
Recommendations for Administration with Enteral Nutrition
ciprofloxacin (Cipro)
Binds to divalent ions (absorption reduced by 50%)
Recommend changing to IV for severe infections. For mild/moderate infections suggest 750 mg BID. Use crushed tablets (suspension may NOT be used with any feeding tube). Consider holding continuous EN for 1-2 hours before and after
Last updated: May. 1, 2024
Renal Adjustment Policy ciprofloxacin subject to adjustments by pharmacy.
(Brand)
• Indications
Comments
(Cipro©)
q8h for pseudomonas
CrCl <30: 200-400 mg q24h
HD/PD: 200-400 mg q24h
(Cipro©)
CrCl 30-50: 250-500 mg q12h
CrCl <30: 500 mg q24h
HD/PD: 250-500 mg q24h
(Brand)
(Cipro)
(max: 400 mg/dose or
40 mg/kg/day)
(max: 750 mg/dose or
40 mg/kg/day)
(Brand)
(Cipro)