Approved Formulary
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methacholine
methacholine
Brand names: Provocholine
| Form | Strength |
|---|---|
| POWDER FOR RECONSTITUTION, INHALATION | 100 mg |
Display Diagnostic Agents Class:
360000
Medication comments:
| Methacholine Dilution Sequence, for respiratory diagnostic studies. | ||
|---|---|---|
| Dilutions | Dilution Directions | Concentrations |
| A | Add 4 mL of 0.9% sodium chloride injection to the 20 mL vial containing 100 mg of methacholine. This is Vial A. | 25 mg/mL |
| B | Remove 1 mL from Vial A using a 3 ml syringe. Add 1.5 mL of 0.9% sodium chloride injection to the syringe. This is Syringe B. | 10 mg/mL |
| C | Remove 1 mL from Vial A using a 10 ml syringe. Add 9 mL of 0.9% sodium chloride injection to the syringe. This is Syringe C. | 2.5 mg/mL |
| D | Remove 1 mL from Syringe C using a 10 ml syringe. Add 9 mL of 0.9% sodium chloride injection to the syringe. This is Syringe D. | 0.25 mg/mL |
| E | Remove 1 mL from syringe D using a 10 ml syringe. Add 9 mL of 0.9% sodium chloride injection to the syringe. This is Syringe E. Syringe E must be prepared on the day of the challenge. | 0.025 mg/ml |
| After dilution, shake well until solution is clear. When transferring solution from each vial to nebulizer, use a sterile 0.22 micron filter. | ||
| Medications Requiring Filters | ||
|---|---|---|
| Medication | Preparation Filter | Administration Filter |
| methacholine (Provocholine) | Not required. | When transferring solution from a vial or syringe to nebulizer, use a sterile 0.22 micron filter. |
Last updated: Feb. 14, 2021
- Black Box Warnings Diagnostic use only
