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amiodarone

amiodarone
  • Restricted Medications Cardiac Monitor (IV)
Brand names: Cordarone, Nexterone
Form Strength
SOLUTION, INTRAVENOUS 50 mg/mL vial; 150 mg/100 mL; 360 mg/200 mL
TABLET, ORAL 200 mg
Display Antiarrhythmic Agents, Class II Antiarrhythmics, Class III Antiarrhythmics Class: 240404, 24040416, 24040420
Medication comments:
amiodarone should generally not be interrupted during procedures unless there is a specific physician order.
Per policy, these medications require cardiac and/or special monitoring.
(KEY: "Y" = may be given as described on chart. "N" = may NOT be given except in Rapid Response/Code Blue situations or as otherwise described in Exceptions section of Policy.
generic (Brand) / Notes CCU, OR, PACU, CCL, ED PCU 2N (Tele) 1N (Tele), 3N (Tele) Med/Surg (1N w/o Tele, 3N w/o Tele, 4N, 5N) BirthPlace SNF ICS OPS
amiodarone (Cordarone)
IV Push, IV Infusion		 Y Y Y N N N N N N
Medications Requiring Filters    
Medication Preparation Filter Administration Filter
amiodarone (Cordarone) Not required. Use a 0.22 micron inline filter.
Adult Extravasation Management
amiodarone (Cordarone)
Agent type: Non-Chemotherapeutic
Vesicant/Irritant: Vesicant
Local Care: Warm compress
Antidote: Hyaluronidase (may consider for refractory cases in addition to supportive measures)
Antidote link(s):
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication: amiodarone (Cordarone, Nexterone, Pacerone)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Drug(s) amiodarone
Rationale Effective for maintaining sinus rhythm but has greater toxicities than other antiarrhythmics used in atrial fibrillation; may be reasonable first-line therapy in patients with concomitant heart failure or substantial left ventricular hypertrophy if rhythm control is preferred over rate control.
Recommendation Avoid as first-line therapy for atrial fibrillation unless the patient has heart failure or substantial left ventricular hypertrophy.
 Quality of evidence: High, Strength of Recommendation: Strong
Last updated: Sep. 18, 2025
UpToDate Lexidrug

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