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Approved Formulary
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hydroCHLOROthiazide-triamterene
hydroCHLOROthiazide-triamterene
Brand names: Maxzide, Maxzide-25
| Form | Strength |
|---|---|
| TABLET, ORAL | 25 mg-37.5 mg; 50 mg-75 mg |
Medication comments:
| Per policy, orders for these non-formulary agents will be changed to formulary equivalents. | |
|---|---|
| Non-Formulary Agent | Formulary Equivalent |
| hydroCHLOROthiazide-triamterene 25-50 mg | hydroCHLOROthiazide-triamterene 25-37.5 mg (Maxzide-25) |
| 2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults. | |
|---|---|
| Medication: | triamterene (Dyrenium), hydroCHLOROthiazide (HCTZ) |
| Criteria 3: Potentially inappropriate medications: drugs to be used with caution in older adults. (Table 4) | |
| Drug(s) | diuretics |
| Rationale | May exacerbate or cause SIADH or hyponatremia; monitor sodium levels closely when starting or changing dosages in older adults. |
| Recommendation | Use with caution |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
| Criteria 4: Potentially clinically important drug-drug interactions that should be avoided in older adults. (Table 5) | |
| Interacting drug(s) or class(es) | potassium-sparing diuretics ⇄ RAS inhibitors (ACEIs, ARBs, ARNIs, aliskiren) |
| Risk Rationale | Increased risk of hyperkalemia. |
| Recommendation | Avoid routinely using 2 or more RAS inhibitors, or a RAS inhibitor and potassium-sparing diuretic, concurrently in those with chronic kidney disease Stage 3a or higher. |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
| Criteria 5: medications that should be avoided or have their dosage reduced with varying levels of kidney function in older adults. (Table 6) | |
| CrCl (mL/min) at which action is required | <30 |
| Rationale | Hyperkalemia and hyponatremia |
| Recommendation | Avoid |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
Last updated: Sep. 18, 2025
- Black Box Warnings Hyperkalemia
- Look-Alike/Sound-Alike hydroCHLOROthiazide confused with hydrALAZINE, hydrOXYzine, hydroxyurea, hydroxychloroquine