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phenytoin IV

phenytoin IV
  • Restricted Medications IV Unit restrictions
Brand names: Dilantin, Dilantin IV
Form Strength
SOLUTION, INJECTABLE 50 mg/mL
Display Class Ib Antiarrhythmics, Hydantoins Class: 24040408, 281212
Medication comments:

Per policy, these medications require cardiac and/or special monitoring.
(KEY: "Y" = may be given as described on chart. "N" = may NOT be given except in Rapid Response/Code Blue situations or as otherwise described in Exceptions section of Policy.
generic (Brand) / Notes CCU, OR, PACU, CCL, ED PCU 2N (Tele) 1N (Tele), 3N (Tele) Med/Surg (1N w/o Tele, 3N w/o Tele, 4N, 5N) BirthPlace SNF ICS OPS
phenytoin (Dilantin)
IV Push,IV infusion		 Y Y Y Y N N N N N
Per policy, these hazardous drugs have special waste requirements. 
Generic (Brand) Waste Requirements
phenytoin (Dilantin) Injection ⇒  BLACK BUCKET 
Medications Requiring Filters   
Medication Preparation Filter Administration Filter
phenytoin sodium (Dilantin) Not required. Use a 0.22 to 0.55 micron inline filter.IMH: For IV infusions, use a 0.22 micron in-line filter.
USP <800> Hazardous Drug Assessment of Risk (AOR)
Per policy, these drugs are exempt from USP <800> handling requirements under normal circumstances.
The following outlines must be followed.
generic (Brand) Route
[Packaging: Manufacturer ⇒ Dispense]		 Activities
phenytoin (Dilantin) IV
[n/a]		   Stock @ IDBH? N
NIOSH Table 2↑
Pharmacy:
Receiving / Storage / Preparation

Exposure Risk: low
 • Handling/preparation PPE Requirements: Single CX glove, gown
• Receiving from Distributor: Standard
• Pharmacy Storage Area: IV Area
• Packaging/Reconstitution Location: n/a
• Compounding (Non-Sterile/Sterile) Location: Positive pressure room
• Omnicell Load: No
Transport • Transport (dose is placed inside a plastic sealable bag): Standard
Nursing:
Storage / Administration

Exposure Risk: moderate
 • Handling/administration PPE Requirements: Single CX glove, gown
• Storage of Finished dose in Nursing Area/Procedural Area: Patient Med Drawer
• Signage on Patient Door Required: No
• Manipulation of Dosage Form: n/a
• Special Manipulation for Administration: n/a
Disposal / Spills • Disposal of Drug Waste: Full-  black bin 
Trace-  yellow bin 
• Disposol of Used PPE: trash bin (inside plastic bag)
• Spill management: n/a
NIOSH Supplemental Information: IARC Group 1 carcinogen; NTP
Reason for exemption of USP<800> Containment Requirements: Preg Category D. No NIOSH requirements but is highest Group for carcinogen to humans; likely only by systemic absorption. For skin contact, remove contaminated clothing, flush area with large amounts of water and soap. Per MSDS, "possible carcinogen"
Adult Extravasation Management
phenytoin (Dilantin,Phenytek)
Agent type: Non-Chemotherapeutic
Vesicant/Irritant: Vesicant
Local Care: Warm compress
Antidote: Hyaluronidase (200 units/mL),nitroglycerin topical 2%
Antidote link(s):
Last updated: Jun. 18, 2025
UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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