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metoclopramide

metoclopramide

Brand names: Reglan

Form	Strength
SOLUTION, INJECTABLE	10 mg/2 mL
SYRUP, ORAL	10 mg/10 mL
TABLET, ORAL	5 mg; 10 mg

Display Prokinetic Agents Class: 563200

Medication comments:

Per policy, these drugs are subject to renal dosing adjustments by pharmacy.
Generic + Route (Brand) • Indications	Usual Adult Dose Comments	Renal Dosage Adjustments
metoclopramide IV/PO (Reglan^©)	Refer toor other reference. No distinction between IV/PO or indication	CrCl > 60: No adjustment necessary CrCl 11-59: Administer 50% of usual total daily dose. CrCl <11,HD/PD: Administer 33% or less of total daily dose.

2023 American Geriatrics Society Beers Criteria^® for potentially inappropriate medication use in older adults.
Medication:	metoclopramide (Reglan)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Drug(s)	metoclopramide
Rationale	Can cause extrapyramidal effects, including tardive dyskinesia; the risk may be greater in frail older adults and with prolonged exposure.
Recommendation	Avoid, unless for gastroparesis with a duration of use not to exceed 12 weeks except in rare cases.
Quality of evidence: Moderate, Strength of Recommendation: Strong

Criteria 2: Potentially inappropriate medication use in older adults due to drug–disease or drug–syndrome interactions that may exacerbate the disease or syndrome. (Table 3)
Drug(s) ⇆ disease or syndrome	antiemetics ⇄ Parkinson disease
Rationale	DOPamine-receptor antagonists with the potential to worsen Parkinsonian symptoms.
Recommendation	Avoid
Quality of evidence: Moderate, Strength of Recommendation: Strong

Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics
Medication:	metoclopramide (Reglan)
Key Potentially Inappropriate Drugs in Pediatrics (KIDs) List: Second Edition (Table 1)
Drug	DOPamine antagonists
Risk/Rationale	Acute dystonic reactions (e.g., oculogyric crisis, torticollis)
Recommendation	Avoid in younger than 1 yr Caution in 1-18 yr of age
Quality of evidence: High, Strength of Recommendation: Strong

Last updated: Sep. 25, 2025

Black Box Warnings Tardive Dyskinesia

UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

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