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linaCLOtide

linaCLOtide
Brand names: Linzess
Form Strength
CAPSULE, ORAL 72 mcg; 145 mcg, 290 mcg
Display Guanylate Cyclase C (GCC) Receptor Agonists Class: 561812
Medication comments:
Enteral Drug Administration notes.
Generic
(Brand)		 Comments and Considerations Recommendations for Administration with Enteral Nutrition
linaCLOtide
(Linzess)		 Do NOT break or chew capsule Do NOT administer through feeding tube
Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics 
Medication: linaclotide (Linzess)
Key Potentially Inappropriate Drugs in Pediatrics (KIDs) List: Second Edition (Table 1)
Drug guanylate cyclase-c agonists
Risk/Rationale Death from dehydration
Recommendation Caution in younger than 2 yr
 Quality of evidence: Very low, Strength of Recommendation: Weak
Last updated: Sep. 25, 2025
UpToDate Lexidrug

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