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Approved Formulary
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captopril-hydroCHLOROthiazide
captopril-hydroCHLOROthiazide
Brand names: Capozide
No brands, forms, or strengths have been added for this generic.
Medication comments:
| 2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults. | |
|---|---|
| Medication: | captopril-hydroCHLOROthiazide (Capozide) |
| Criteria 3: Potentially inappropriate medications: drugs to be used with caution in older adults. (Table 4) | |
| Drug(s) | diuretics |
| Rationale | May exacerbate or cause SIADH or hyponatremia; monitor sodium levels closely when starting or changing dosages in older adults. |
| Recommendation | Use with caution |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
| Criteria 4: Potentially clinically important drug-drug interactions that should be avoided in older adults. (Table 5) | |
| Interacting drug(s) or class(es) | RAS inhibitors (ACEIs ARBs, ARNIs, aliskiren) ⇄ Another RAS inhibitor or a potassium-sparing diuretic |
| Risk Rationale | Increased risk of hyperkalemia. |
| Recommendation | Avoid routinely using 2 or more RAS inhibitors, or a RAS inhibitor and potassium-sparing diuretic, concurrently in those with chronic kidney disease Stage 3a or higher. |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
Last updated: Sep. 20, 2025
- Black Box Warnings captopril: Pregnancy risk
- Look-Alike/Sound-Alike hydroCHLOROthiazide confused with hydrALAZINE, hydrOXYzine, hydroxyurea, hydroxychloroquine