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Houston Methodist

Approved Hospital Formulary

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Black Box Warnings

Please review each of these drugs carefully.

abacavir	Hypersensitivity
abacavir-lamivudine	Abacavir: hypersensitivity reactions; lactic acidosis, hepatomegaly
abacavir/dolutegravir/lamivudine	Hypersensitivity Reactions, Lactic Acidosis and Severe Hepatomegaly; Exacerbations of Hepatitis B
acetaminophen	Hepatotoxicity
acetaminophen-codeine	Addiction, Abuse, And Misuse; Life-Threatening Respiratory Depression; Risks From Concomitant Use With Benzodiazepines
acetaminophen-hydrocodone	Acetaminophen - Hepatotoxicity Hydrocodone - Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
acetaminophen-oxycodone	Addiction, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; and Hepatotoxicity
acetaminophen-tramadol	Addiction, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; and Hepatotoxicity
acetylcysteine	Inhalation solution: not for injection
acitretin	Pregnancy/Teratogenecity
adalimumab	Infection risk; malignancy in children and adolescents
adefovir	Exacerbation of Hepatitis; Nephrotoxicity; HIV Resistance; Lactic Acidosis, Severe Hepatomegaly
ado-trastuzumab emtansine	Hepatotoxicity, Cardiac Toxicity, Embryo-Fetal Toxicity
aducanumab	AMyloid Related Imaging Abnormalities
albiglutide	Risk of Thyroid C Cell Tumors
aldesleukin	Capillary Leak Syndrome
alemtuzumab	Hematological toxicity; opportunistic infections
alfentanil	Addiction, Abuse, and Misuse
aliskiren	Pregnancy risk
ALPRAZolam	Risks From Concomitant Use in Opioids
alprostadil	Apnea
alvimopan	Short-term hospital use only
ambrisentan	Hepatic Injury; pregnancy risk; restricted distribution
amikacin	Neurotoxicity; nephrotoxicity
aMILoride	Hyperkalemia
amiloride-hydrochlorothiazide	Amiloride: Hyperkalemia
amiodarone	Oral: Pneumonitis; Proarrhythmic Effects
amitriptyline	Suicidal ideation in children, adolescents
amitriptyline-chlordiazepoxide	Risk From Concomitant Use With Opioids
amitriptyline-perphenazine	Increased Mortality in Elderly Patients with Dementia-Related Psychosis
amlodipine-benazepril	Benazepril: ACE inhibitor pregnancy risk
amphetamine-dextroamphetamine	Abuse/diversion potential; drug dependence
amphotericin B	Noninvasive fungal disease; avoid overdose
andexanet alfa	Thromboembolic Risks, Ischemic Risks, Cardiac Arrest, and Sudden Deaths
anti-thymocyte globulin (rabbit)	Used by Experienced Physicians in Immunosuppressive Therapy
apixaban	Discontinuation without anticoagulation
arformoterol	Asthma Related Death
ARIPiprazole	Elderly patients with dementia related psychosis
arsenic trioxide	Cardiac toxicity
ascorbic acid-ferrous fumarate	Iron Overdose Risk
asenapine	Mortality in elderly patients with dementia related psychosis
asparaginase Escherichia coli	Anaphylaxis; sudden death
aspirin/butalbital/caffeine/codeine	Codeine in children: death due to ultra-rapid metabolism
atenolol	Avoid abrupt withdrawal
atomoxetine	Suicidal Ideation
axicabtagene ciloleucel	Cytokine Release Syndrome and Neurologic Toxicities
azaTHIOprine	Risk of neoplasia, infections
bacitracin	Injection: Nephrotoxicity
baclofen	Intrathecal: Abrupt discontinuation
balsalazide	Renal Impairment
Bamlanivimab	Limitations of Authorized Use for COVID-19:
basiliximab	Prior to initiation of therapy
BCG	Risk of infection; biohazard handling precautions
becaplermin topical	Increased risk of secondary malignancy
belantamab mafodotin	Ocular Toxicity
belatacept	Post transplant lymphoproliferative disorder; serious infections
benazepril	ACE inhibitor pregnancy risk
benzathine penicillin-procaine penicillin	Not for Intravenous Use
betrixaban	Spinal/Epidural Hematoma
bevacizumab	GI perforation; wound healing complications
bleomycin	Pulmonary Fibrosis; Idiosyncratic Reactions
blinatumomab	Cytokine Release Syndrome and Neurological Toxities
bosentan	Hepatotoxicity; teratogenecity
brentuximab vedotin	Progressive Multifocal Leukoencephalopathy (PML)
brexanolone	Excessive Sedation and Sudden Loss of Consciousness
brexucabtagene autoleucel	Cytokine Release Syndrome and Neurologic Toxicities
budesonide-formoterol	Asthma Related Death
bumetanide	Potent diuretic
bupivacaine	Intravascular injection risk; 0.75% strength caution
bupivacaine-epinephrine	Bupivacaine: Intravascular injection risk; 0.75% strength caution
bupivacaine/meloxicam	Risk of Serious Cardiovascular and Gastroinstestinal Events
buprenorphine	Addiction, Abuse, And Misuse; Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; Risks From Concomitant Use With Benzodiazepines
buprenorphine-naloxone	Implant: Implant Migration, Protrusion, Expulsion, and Nerve Damage Associated with Insertin and Removal
buPROPion	Suicidal Ideation
busulfan	Myelosuppression
butorphanol	Addiction, Abuse, And Misuse; Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; and Risks From Concomitant Use With Benzodiazepines
cabazitaxel	Hemtalogical & Hypersensitivity Reactions
candesartan	Pregnancy risk
capecitabine	Warfarin Interaction
captopril	Pregnancy risk
carBAMazepine	Hematological Risk; Serious Dermatologic Reactions
carbidopa-levodopa	Bolded (not boxed): Carbidopa dosing
carbidopa/entacapone/levodopa	Bolded (not boxed): Carbidopa dosing
carbonyl iron	Iron Overdose Risk
CARBOplatin	Myelosuppression; Anaphylaxis risk
carfilzomib	Cardiac Toxicities; Tumor Lysis Syndrome; Pumonary Toxicity; Dyspnea; Hyprertension
carmustine	Bone Marrow Suppression; Pulmonary Toxicity
celecoxib	Cardiovascular, gastrointestinal risk
certolizumab	Serious infection risk
cetuximab	Infusion Reactions; Cardiopulmonary Arrest
chlorambucil	Bone marrow suppression; teratogen
chloramphenicol	Fatal blood dyscrasias
chlordiazePOXIDE	Risks From Concomitant Use With Opioids
chlordiazepoxide-clidinium	Risks From Concomitant Use With Opioids
chloroquine	Prior to initiation of therapy
chlorpheniramine-hydrocodone	Tussionex Pennkinetic and Vituz - Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
chlorproMAZINE	Mortality in elderly with dementia
cidofovir	Nephrotoxicity; neutropenia
cilostazol	CHF patient contraindication
ciprofloxacin	Tendinitis; tendon rupture
CISplatin	Nephrotoxicity; Myelosuppression
citalopram	Suicidal Thoughts and Behaviors
cladribine	Bone Marrow Suppression; Neurotoxicity; Nephrotoxicity
clindamycin	Pseudomembranous colitis
cloBAZam	Risk From Concomitant Use with Opiods
clomiPRAMINE	Suicidal Ideation
clonazePAM	Risk From Concomitant Use With Opioids
cloNIDine	Epidural Clonidine
clopidogrel	Poor CYP2C19 metabolizers
clorazepate	Risks From Concomitant Use With Opioids
cloZAPine	Agranulocytosis, myocarditis, seizure risk
coagulation factor VIIa	Serious Thrombotic Adverse Events Associated with Recombinant Coagulation Factor VIIa Outside Label Indicatons
cobicistat/elvitegravir/emtricitabine/tenofovir disoproxil fumarate	Lactic acidosis, severe hepatomegaly; hepB co-infection
cocaine topical	Topical: Not for injection or ophthalmic use.
codeine	Addiction, Abuse, And Misuse; Respiratory Depression; Neonatal Opioid Withdrawal Syndrome; and Risks From Concomitant Use With Benzodiazepines
codeine-guaifenesin	Codeine in children: death due to ultra-rapid metabolism
codeine-promethazine	Codeine in children: death due to ultra-rapid metabolism Promethazine: contraindicated in patients < 2 years
conjugated estrogens	Endometrial cancer; cardiovascular; dementia risk
conjugated estrogens topical	Endometrial cancer; cardiovascular; dementia risk
cycloSPORINE	Infection, neoplasm, nephrotoxicity risk
cytarabine	Prior to initiation of therapy
cytarabine liposomal	Chemical arachnoiditis
dabigatran	Discontinuation without anticoagulation
dacarbazine	Hemopoietic depression; hepatic necrosis risk
DACTINomycin	Handling precautions; extravasation risk
dalfopristin-quinupristin	Approved indication
dalteparin	Spinal/epidural hematoma risk
danazol	Pregnancy contraindication; stroke risk; hepatic risk with long term use; benign intracranial hypertension
dantrolene	Hepatotoxicity
darbepoetin alfa	Mortality, serious CV events, tumor progression or recurrence
darunavir/cobicistat/emtricitabine/tenofovir alafenamide	Post Treatment Acture Exacerbation of Hepatitis B
DAUNOrubicin	Myocardial Toxicity and Severe Myelosuppression
deferasirox	Renal Failure, Hepatic Failure, GI Hemorrhage
delafloxacin	Serious Adverse Reactions Including Tendinitis, Tendon Rupture, Peripheral Neuropathy, Cental Nervous System Effects, and Exacerbation of Myasthenia Gravis
denosumab	Severe Hypocalcemia in Patients with Advanced Kidney Disease
desipramine	Suicidal Ideation
desvenlafaxine	Suicidal ideation
dextroamphetamine	Abuse/diversion potential; drug dependence
dextromethorphan-quinidine	Quinidine: Active antiarrhythmic therapy may increase mortality
diatrizoate	Not for intrathecal use
diazePAM	Risks From Concomitant Use With Opioids
diclofenac	Cardiovascular, gastrointestinal risk
diclofenac topical	Cardiovascular risk; Gastrointestinal Risk
diclofenac-misoprostol	Risk of Uterine Rupture, Abortion, Premature Birth, Birth Defects; and Serious Cardiovascular and Gastrointestinal Events
didanosine	Pancreatitis, hepatotoxicity, lactic acidosis risk
dihydroergotamine	Drug interaction risk
dinoprostone topical	Suppository: use recommended dose
disopyramide	Mortality Risk
disulfiram	Administer with patient consent
divalproex sodium	Hepatotoxicity; mitochondrial disease; fetal risk
DOCEtaxel	Hepatic dysfunction, hypersensitivity risk
dofetilide	Initiation or re-initiation monitoring
DOPamine	Peripheral ischemia risk
doravirine/lamivudine/tenofovir disoproxil	Post-Treatment Acute Exacerbation of Hepatitis B
doxepin	Suicidal Ideation
DOXOrubicin	Cardiac, hepatic, myelosuppression, extravasation risk
DOXOrubicin liposomal	Cardiac, acute infusion reaction, myelosuppresssion risk
dronedarone	Contraindication in certain CHF conditions
droperidol	QT prolongation; cardiac risk
dulaglutide	Risk of Thyroid C Cell Tumors
DULoxetine	Suicidal Ideation
eculizumab	Meningococcal Infection
edetate calcium disodium	Lead encephalopathy risk
efavirenz/emtricitabine/tenofovir	Lactic Acidosis; Severe Hepatomegaly with Steatosis and Post Treatment Exacerbation of Hepatitis B
eltrombopag	Risk for Hepatotoxicity, Restricted Distribution
emtricitabine	Lactic Acidosis, Severe Hepatomegaly
emtricitabine-tenofovir	Lactic acidosis; severe hepatomegaly; hepB co-infection
emtricitabine/rilpivirine/tenofovir	Lactic acidosis, severe hepatomegaly; hepB co-infection
enalapril	Pregnancy risk
enoxaparin	Spinal/epidural hematoma risk
entecavir	Lactic acidosis, severe hepatomegaly; hepB co-infection
epiRUBicin	Cardiac Toxicity, Secondary Malignancies, Extravasation & Tissue Necrosis, and Severe Myelosuppression
epoetin alfa	Risk of mortality, tumor progression, cardiac events
escitalopram	Suicidal ideation
esketamine	Sedation; Dissociation; Abuse and Misuse; and Surcidal Thoughts and Behaviors
esterified estrogens	Endometrial cancer; cardiovascular; dementia risk
estradiol	Transdermal: endometrial cancer; cardiovascular; dementia risk Vaginal cream/tab: endometrial cancer; cardiovascular; dementia risk
estradiol topical	Endometrial cancer; cardiovascular; dementia risk
estropipate	Endometrial cancer; cardiovascular; dementia risk
eszopiclone	Risk of Serious Injuries With Certain Prescription Insomnia Medications
etanercept	Infection risk; tuberculosis
ethacrynic acid	Potent Diuretic
ethinyl estradiol-norethindrone	Cigarette smoking; risk of cardiovascular disease
ethiodized oil	For Intralymphatic, Intrauterine and Selective Hepatic Intra-Arterial Use Only
etodolac	Cardiovascular; gastrointestinal risk
etoposide	Myelosuppression risk
everolimus	Malignancies and Serious Infections, Nephrotoxicity, Kidney Graft Thrombosis, Mortality in Heart Transplantation
exenatide	Extended Release Injection: Risk of thyroid c-cell tumors
fam-trastuzumab deruxtecan-nxki	Interstitial Lung Disease and Embryo-Fetal Toxocity
fat emulsion, intravenous	Cautious use in infants Death in preterm infants
febuxostat	Cardiovascular Death
fentaNYL	Buccal Tablet: Serious adverse events, deaths; abuse potential Nasal Spray: Schedule II Controlled Substance: Abuse potential Sublingual Spray: Risk of respiratory depression, medication errors, abuse potential Transdermal: High concentration of Schedule II opioid agonist
ferrous fumarate-folic acid	Iron Overdose Risk
ferrous gluconate	Iron Overdose Risk
ferrous sulfate	Iron Overdose Risk
ferumoxytol	Risk for Serious Hypersensitivity/ Anaphylaxis Reactions
flecainide	Cardiovascular risk
flucytosine	Hepatic, hematologic risks; caution in renal impairment
fludarabine	Neurotoxicity, hemolytic anemia risk
flumazenil	Seizure Risk
fluorouracil	Hematologic risk
FLUoxetine	Suicidal Ideation
fluPHENAZine	Mortality in elderly with dementia
flurazepam	Risks From Concomitant Use With Opioids
flutamide	Hepatotoxicity
fluticasone-salmeterol	Salmeterol: asthma related death; pediatric and adolescent patients
fluticasone-vilanterol	Vilanterol: Asthma-related death
fluvoxaMINE	Suicidal Ideation
fondaparinux	Spinal/epidural hematoma risk
formoterol	Asthma Related Death
foscarnet	Nephrotoxicity; seizure risk
fosphenytoin	Cardiovascular risk with rapid infusion
furosemide	Potent Diuretic
gadobenate dimeglumine	Nephrogenic Systemic Fibrosis
gadobutrol	Nephrogenic Systemic Fibrosis
gadodiamide	Nephrogenic Systemic Fibrosis
gadofosveset trisodium	Nephrogenic Systemic Fibrosis
gadopentetate dimeglumine	Nephrogenic Systemic Fibrosis
gadoterate meglumine	Nephrogenic Systemic Fibrosis
gadoxetate	Nephrogenic Systemic Fibrosis
ganciclovir	Hematological toxicity; IV and oral different indications
gentamicin	Ototoxicity; Nephrotoxocity
glyburide-metformin	Metformin: Lactic Acidosis
glycopyrrolate-indacaterol	Asthma-related death
haloperidol	Mortality in elderly with dementia
hemin	Use only after alternate therapy failure
heparin	Spinal/Epidural Hematomas
hetastarch	Mortality and Renal Injury Requiring Renal Replacement Therapy
homatropine-hydrocodone	Hycodan - Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
hydrochlorothiazide-irbesartan	When pregnancy is detected, this drug should be discontinued as soon as possible.
hydrochlorothiazide-losartan	Angiotensin II antagonist pregnancy risk
hydrochlorothiazide-spironolactone	Possible tumorigen
hydrochlorothiazide-triamterene	Hyperkalemia
HYDROcodone	Extended release: Abuse; Respiratory Depression; Accidental Ingestion; Withdrawal; Interactions
hydrocodone-ibuprofen	NSAIDS - Cardiovascular; gastrointestinal risk Hydrocodone - Addiction, Abuse, and Misuse
HYDROmorphone	Injection: Respiratory depression risk; abuse potential Injection, High Potency: Opioid-tolerant patients only; Respiratory depression risk; abuse potential Oral, extended release: Opioid-tolerant patients only; overdose risk; abuse potential Oral, liquid & tablets: Abuse potential; respiratory depression; neonatal withdrawal; alcohol interaction
hydroxychloroquine	Prior to initiation of therapy
hydroxyurea	Prior to initiation of therapy
ibritumomab	Fatal infusion reactions, cytopenias, dosing, cutaneous reactions
ibuprofen	Cardiovascular; gastrointestinal risk
ibutilide	Potentially Fatal Arrhythmias
IDArubicin	Cardiotoxicity; myelosuppression; renal/hepatic impairment; avoid extravasation
idecabtagene vicleucel	Cytokine Release Syndrome, Neurologic Toxicities, HLM/MAS and Prolonged Cytopenia
ifosfamide	Urotoxicity; myelosuppressionm CNS toxicity
iloperidone	Mortality in elderly patients with dementia related psychosis
imipramine	Suicidal ideation
immune globulin intravenous	Renal dysfunction, acute renal failure
indomethacin	Cardiovascular; gastrointestinal risk
inFLIXimab	Serious infection risk; hepatosplenic t-cell lymphomas; malignancy
inotuzumab ozogamicin	Hepatotoxicity, Including Hepatic Veno-Occlusive Disease (VOD - also known as Sinusoidal Obstruction Syndrome) and Increased Risk of Post-Hematopoietic Stem Cell Transplant (HSCT) Non-Relapse Mortality
interferon alfa-2b	Neuropsychiatric, autoimmune, ischemic and infectious disorders
iodixanol	Not for intrathecal use
iopamidol	Not for intrathecal use
ipilimumab	Immune-Mediated Adverse Reactions
irbesartan	ACE inhibitor pregnancy risk
irinotecan	Severe diarrhea
iron dextran	Injection: Anaphylactic reaction risk
iron polysaccharide	Iron overdose risk
iron sucrose	Iron overdose risk
isoniazid	Hepatitis
itraconazole	Congestive heart failure, drug interactions
ixabepilone	Toxicity in hepatic impariment
ketamine	Emergence reactions; psychological manifestations
ketoconazole	Oral: hepatoxicity, drug interactions
ketoprofen	Cardiovascular; gastrointestinal risk
ketorolac	Duration of therapy; max dose; GI, cardiovascular, bleeding, renal risk
lamiVUDine	Lactic acidosis, hepatomegaly; exacerbations of hepatitis b; dosing formulation
lamivudine-zidovudine	Lamivudine: Lactic acidosis, hepatomegaly; exacerbations of hepatitis b; dosing formulation Zidovudine: Hematological adverse events; myopathy; lactic acidosis; hepatomegaly
lamoTRIgine	Serious dermatological reactions
lecanemab	Amyloid Related Imaging Abnormalities
leflunomide	Pregnancy risk
lenalidomide	Embryo-Fetal Toxicity and Restricted Distribution Program, Hematologic Toxicity, Venous Thromboembolism
levoFLOXacin	Tendinitis, tendon rupture; Pediatric Use
levonorgestrel	Bolded (not boxed): Not Protective Against HIV
levothyroxine	Treatment of obesity or weight loss
lidocaine topical	Lidocaine, viscous: Do NOT use for teething pain
lindane topical	Neurotoxicity
liothyronine	Treatment of obesity or weight loss
liraglutide	Thyroid C-cell Tumors
lisinopril	ACE inhibitor pregnancy risk
lisocabtagene maraleucel	Cytokine Release Syndrome and Neurologic Toxicities
lithium	Monitoring recommendations
lomustine	Bone marrow suppression
lopinavir-ritonavir	Ritonavir: Drug interactions
LORazepam	Risks From Concomitant Use With Opioids
losartan	Pregnancy risk
loxapine	Elderly patients with dementia related psychosis Aerosol: Bronchospasm
lurasidone	Mortality in elderly patients with dementia related psychosis
LVP solution	Extraneal: Unrecognized Hypoglycemia Resulting From Drug-Device Interaction
lymphocyte immune globulin, anti-thy (equine)	Prior to initiation of therapy
macitentan	Embryo-Fetal Toxicity
mannitol	Severe bronchospasm risk
maraviroc	Hepatotoxicity
medroxyPROGESTERone	Oral: Cardiovascular and other risks Injection: Loss of Bone Mineral Density
mefloquine	Neuropsychiatric events
meloxicam	Cardiovascular; gastrointestinal risk
melphalan	Bone marrow suppression; hypersensitivity reactions; pregnancy risk
meperidine	Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome
mercaptopurine	Bolded (not boxed): initiation of therapy
metFORMIN	Lactic Acidosis
methacholine	Diagnostic use only
methadone	Risk during initiation of or conversion to methadone
methohexital	Continuous monitoring of respiratory and cardiac function
methotrexate	Bone marrow, liver, lung and kidney toxicity risk
methoxsalen	Injection: Used Only By Specialized Physicians Oral: Methoxsalen with UV radiation should be used only by physicians who have special competence in the diagnosis and treatment of psoriasis and who have special training and experience in photochemotherapy.
methyldopa	Fixed combination for initial hypertension management
methylene blue	Serotonin Syndrome with Concomitant Use of Serotonergic Drugs
methylphenidate	Tolerance and dependence
metoclopramide	Tardive Dyskinesia
metOLazone	Bolded (not boxed): do not interchange
metoprolol	Avoid Abrupt Withdrawal (Oral) (Warning Removed 1/2022)
metroNIDAZOLE	Carcinogenicity
mexiletine	Mortality; Acute Liver Injury
midazolam	Individualize dose
midodrine	Supine blood pressure > 180 mmHg
milnacipran	Suicidal ideation
minoxidil	Antihypertensive risk
mirtazapine	Suicidal ideation
mirvetuximab soravtansine	Ocular Toxicity:
miSOPROStol	Pregnancy risk
mitoMYcin	Bone marrow suppression; hemolytic uremic syndrome
mitoXANTRONE	Cardiotoxicity; baseline neutrophil count; extravasation risk
montelukast	Serious Neuropsychiatric Events
morphine	Injection PreserveFree: 24-hour observation following epidural/intrathecal administration Controlled/Extended Release: Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome
mosunetuzumab	Cytokine Release Syndrome
Moxetumomab Pasudotox	Capillary Leak Syndrome and Hemolytic Uremic Syndrome
moxifloxacin	Tendinitis, tendon rupture
multivitamin with iron	Iron overdose risk
mycophenolate mofetil	Prior to initiation of therapy
mycophenolic acid	Embryofetal Toxicity, Malignancies, and Serious Infections
nabumetone	Cardiovascular; gastrointestinal risk
nadolol	Avoid abrupt withdrawal
nalbuphine	Life-Threatening Respiratory Depression
naloxone-pentazocine	Addiction, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome
naproxen	Cardiovascular; gastrointestinal risk
natalizumab	Progressive multifocal leukoencephalopathy (PML)
neomycin	Neurotoxicity, nephrotoxicity, ototoxicity; general toxicity
nevirapine	Hepatotoxicity; dermal reactions; patient monitoring
niMODipine	Serious harm with IV administration of oral product
norepinephrine	Extravasation risk
nortriptyline	Suicidal ideation
obinutuzumab	Hepatitis B Virus Reactivation and Progressive Multifocal Leukoencephalopathy
ofatumumab	Hepatitis B Virus (HBV) Reactivation/Progressive Multifocal Leukoencephalopathy
OLANZapine	Mortality in elderly with dementia related psychosis
olmesartan	ACE inhibitor pregnancy risk
olodaterol-tiotropium	Asthma-related death
omalizumab	Anaphylaxis
onabotulinumtoxinA	Distant spread of toxin effect
oprelvekin	Allergic reactions, including anaphylaxis
oxaliplatin	Anaphylactic-like reactions
oxandrolone	Peliosis hepatitis; Liver Cell Tumors; Blood Lipid Changes
oxaprozin	Cardiovascular; gastrointestinal risk
oxazepam	Risks From Concomitant Use With Opioids
oxyCODONE	Oral solution: Risk of errors Controlled release: Abuse potential
oxyMORphone	Abuse/diversion potential; drug dependence
oxytocin	Elective induction of labor
PACLitaxel	Prior to initiation of therapy
PACLitaxel protein-bound	Prior to initiation of therapy
paliperidone	Mortality in elderly patients with dementia related psychosis
pancuronium	Bolded (not boxed): adequate training
panitumumab	Dermatologic toxicity; infusion reactions
PARoxetine	Suicidal ideation
peginterferon alfa-2b	Neuropsychiatric, autoimmune, ischemic and infectious disorders
pegloticase	Anaphylaxis and Infusion Reactions
penicillAMINE	Toxicity risk
perampanel	Serious psychiatric and behavioral reactions
perflutren	Serious cardiopulmonary reactions
perindopril	ACE inhibitor pregnancy risk
perphenazine	Elderly patients with dementia related psychosis
pertuzumab	Cardiomyopathy and Embryo-Fetal Toxicity
pertuzumab/trastuzumab/hyaluronidase-zzxf	Cardiomyopathy, Embryo-Fetal Toxicity, and Pumonary Toxicity
phenylephrine	Prior to initiation of therapy
phenytoin	Cardiovascular risk with rapid infusion
phytonadione	Severe reactions with IM and IV use
pimozide	Elderly patients with dementia related psychosis
pioglitazone	Congestive heart failure
polymyxin B sulfate	Parenteral use: nephrotoxicity, neurotoxicity, pregnancy risk
pomalidomide	Embryo-Fetal Toxicity
prasugrel	Bleeding risk
primaquine	Prior to initiation of therapy
procainamide	Positive titers with chronic administration
procarbazine	Prior to initiation of therapy
prochlorperazine	Elderly patients with dementia related psychosis
progesterone	Cardiovascular disorders; breast cancer; probable dementia
promethazine	Patients < 2 years; severe tissue injury
propafenone	Mortality (CAST trial results)
propranolol	Avoid abrupt withdrawal
propylthiouracil	Severe liver injury; acute liver failure
protamine	Hypotension, pulmonary hypertension; risk factors described
prothrombin complex	Arterial and venous thromboembolic complications
protriptyline	Suicidal ideation
QUEtiapine	Elderly patients with dementia related psychosis
quiNIDine	Active antiarrhythmic therapy may increase mortality
quiNINE	No benefit in leg cramps; hematologic risks
raloxifene	Risk of VTE and death from stroke
ramipril	Olmesartan: ACE inhibitor pregnancy risk
ramucirumab	Increased Risk of Hemorrhage
rasburicase	Anaphylaxis; hemolysis; methemoglobinemia; uric acid measure interference
ravulizumab	Serious Meningococcal Infections
remdesivir	Black Box Warning is for Use of Remdesivir to Treat COVID-19. Remdesivir Must Be Administered by Intravenous (IV) Infusion.
remifentanil	Addiction, Abuse, and Misuse
RHo (D) immune globulin	Intravenous - Intravascular Hemolysis
ribavirin	Oral: Monotherapy; hemolytic anemia; teratogenicity Inhalation: Respiratory function deterioration
riociguat	Embryo-Fetal Toxicity
risperiDONE	Elderly patients with dementia related psychosis
ritonavir	Drug interaction risk
riTUXimab	Fatal infusion reaction; mucocutaneous reactions; progressive multifocal leukoencephalopathy; hep b reactivation
rivaroxaban	Premature discontinuation; spinal/epidural hematomas
rocuronium	Prior to initiation of therapy
romosozumab-aqqg	Potential Risk of Myocardial Infarction, Stroke and Cardiovascular Death
rosiglitazone	Thiazolidinediones, including pioglitazone and rosiglitazone, cause or exacerbate congestive heart failure in some patients.
sacituzumab govitecan-hziy	Neutropenia and Diarrhea
sacubitril-valsartan	Valsartan: ACE inhibitor pregnancy risk
salmeterol	Asthma Related Deaths
salsalate	Cardiovascular; gastrointestinal risk
saquinavir	Bioequivalency
selegiline	Suicidal ideation
semaglutide	Risk of Thyroid C Cell Tumors
sertraline	Suicidal ideation
sirolimus	Immunosuppression; liver or lung transplant patients
sodium nitrite-sodium thiosulfate	Life Threatening Hypotension and Methemoglobin Formation
sodium nitroprusside	Cyanide toxicity; hypotension risk; dilute
sodium phosphate	Phosphate nephropathy
sotalol	Therapy initiation; renal impairment caution; product selection
spironolactone	Possible tumorigen
stavudine	Pancreatitis, lactic acidosis, hepatomegaly
streptomycin	Neurotoxicity; nephrotoxicity
succinylcholine	Hyperkalemic rhabdomyolysis in infants or children
SUFentanil	Addition, Abuse, and Misuse
sulfur hexafluoride	Serious cardiopulmonary reactions
sulindac	Cardiovascular; gastrointestinal risk
tacrolimus	Lymphoma risk; infection related to immunosuppression
tagraxofusp-erzs	Capillary Leak Syndrome
talquetamab	Cytokine Release Syndrome and Neurologic Toxicity, including Immune Effector Cell-Associated Neurotoxicity Syndrome
tamoxifen	Women at high risk for breast cancer; women with DCIS
tapentadol	Abuse potential; limitations of use
tebentafusp	Cytokine Release Syndrome
teclistamab	Cytokine Release Syndrome and Neurologic Toxicity including Immune Effector Cell-associated Neurotoxicity Syndrome
telavancin	Increased Mortality/Nephrotoxicity/Fetal Risk
telmisartan	ACE inhibitor pregnancy risk
temazepam	Risks From Concomitant Use With Opioids
tenofovir	Lactic acidosis, severe hepatomegaly; hepB co-infection
terbutaline	Preterm labor (injectable and oral)
terlipressin	Serious or fatal respiratory failure
testosterone	Secondary exposure to testosterone Testosterone undecanoate, injection: POME reactions and anaphylaxis
thalidomide	Teratogen; informed consent required
thioridazine	QTc prolongation; elderly with dementia related psychosis
thiothixene	Elderly patients with dementia related psychosis
thrombin topical	Bleeding, thrombosis risk
thyroid desiccated	Treatment of obesity or weight loss
ticagrelor	Bleeding Risk
ticlopidine	Severe hematological adverse events
tigecycline	All cause mortality
tipranavir	Both fatal and nonfatal intracranial hemorrhage have been reported.
tisagenlecleucel	Cytokine Release Syndrome and Neurological Toxicities
tiZANidine	Bolded (not boxed): bioequivalence between products
tobramycin	Ototoxicity, nephrotoxicity risk with IV use
tocilizumab	Serious infections risk
tolcapone	Hepatotoxicity
tolvaptan	Initiation or re-initiation monitoring
topotecan	Bone marrow suppression
traMADol	Addiction, Abuse, and Misuse; Life-Threatening Depression; Accidental Exposure; Neonatal Opioid Withdrawal Syndrome; and Hepatotoxicity
tranylcypromine	Suicidal ideation
trastuzumab	Cardiomyopathy; infusion reactions, pulmonary toxicity; teratogenicity
trastuzumab and hyaluronidase-oysk	Cardiomyopathy, Embryo-Fetal Toxicity and Pulmonary Toxicity
traZODone	Suicidal ideation
tretinoin	Acute promyelocytic leukemia; experienced physician
triamterene	Hyperkalemia
trifluoperazine	Elderly patients with dementia related psychosis
trimipramine	Suicidal ideation
umeclidinium-vilanterol	Vilanterol: Asthma-related death
valGANciclovir	Hematologic Toxicity; Impairment of Fertility; Fetal Toxocity; Mutagenesis & Carcinogenesis
valproic acid	Risk to children exposed in utero
valsartan	ACE inhibitor pregnancy risk
vancomycin	Risk of Embryo-Fetal Toxicity Due to Excipient Containing Products
varenicline	Serious neuropsychiatric events, monitoring and patient counseling
venlafaxine	Suicidal ideation
vilazodone	Suicidal ideation
vinBLAStine	IV use only; granulocytopenia; avoid extravasation
vinCRIStine	IV use only; dose liposomal product differently
vinorelbine	IV use only; granulocytopenia; avoid extravasation
vortioxetine	Suicidal Thoughts and Behaviors
warfarin	Serious bleeding risk
zaleplon	Risk of Serious Injuries With Certain Prescription Insomnia Medications
zidovudine	Hematological adverse events; myopathy; lactic acidosis; hepatomegaly
ziprasidone	Mortality in elderly with dementia related psychosis
ziv-aflibercept	Gastrointestinal hemorrhage and perforation; Compromised wound healing
zolpidem	Complex Sleep Behaviors

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