Policies and procedures

Policy and Procedure System_RXCLIN 107 Rasburicase Fixed-Dose Policy

Key Points:

• Rasburicase is limited to a single, fixed dose for prophylaxis or treatment of hyperuricemia based on the following parameters:
  
  • Uric acid level < 15 mg/dL - single dose not to exceed 3 mg
  • Uric acid level > 15 mg/dL - single dose not to exceed 7.5 mg
• Pharmacist may round dose in accordance with the parameters above "per policy"
• A second dose may be administered if hyperuricemia persists after 24 hours in accordance with the parameters above
• Uric acid levels should be monitored at baseline, 4 hours after administration, and then every 6-8 hours until tumor lysis syndrome resolution "per policy"
• Order verifying pharmacist shall notify the pharmacy clinical specialist of rasburicase orders not in accordance with this policy

Consults, protocols, and therapeutic interchanges

Additional information

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