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omeprazole-sodium bicarbonate

omeprazole-sodium bicarbonate
  • Restricted Medications Non-Formulary
Brand names: Zegerid
No brands, forms, or strengths have been added for this generic.
Display Proton-pump Inhibitors Class: 562836
Medication comments:

Per policy, orders for these non-formulary agents will be changed to formulary equivalents.  
Non-Formulary Agent Formulary Equivalent
omeprazole-sodium bicarbonate (Zegerid) pantoprazole (Protonix) 40 mg PO at same frequency (esomeprazole (NexIUM) 40 mg packets if patient receives medication through a tube)
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication: omeprazole-sodium bicarbonate (Zegerid)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Drug(s) proton-pump inhibitors
Rationale Risk of C. difficile infection, pneumonia, GI malignancies, bone loss, and fractures.
Recommendation Avoid scheduled use for >8 weeks unless for high-risk patients (e.g., oral corticosteroids or chronic NSAID use), erosive esophagitis, Barrett's esophagitis, pathologic hypersecretory condition, or demonstrated need for maintenance treatment (e.g., because of failure of drug discontinuation trial or H2-receptor antagonists).
 Quality of evidence: C. difficile, bone loss, and fractures: High
Pneumonia and GI malignancies: Moderate, Strength of Recommendation: Strong
Last updated: Nov. 4, 2025
UpToDate Lexidrug

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