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pantoprazole

pantoprazole
Brand names: Protonix, Protonix IV
Form Strength
DELAYED RELEASE TABLET, ORAL 20 mg; 40 mg
POWDER FOR INJECTION, INTRAVENOUS 40 mg
Display Proton-pump Inhibitors Class: 562836
Medication comments:

Per policy, orders for these non-formulary agents will be changed to formulary equivalents.
Non-Formulary Agent Formulary Equivalent
pantoprazole (Protonix) for pediatric patients esomeprazole (NexIUM) granules - see details there
pantoprazole (Protonix) per tube esomeprazole (NexIUM) granules - see details there
Per policy, these drugs may be converted from IV to PO in patients who meet criteria.  
pantoprazole(Protonix) may convert from IV to PO on a mg-to-mg basis.
Enteral Drug Administration notes.
Generic
(Brand)		 Comments and Considerations Recommendations for Administration with Enteral Nutrition
pantoprazole
(Protonix)		 Crushing DR tablet can clog tubes. Substitute to esomeprazole delayed-release granules. No dose adjustment when using compounded suspension. Do NOT use DR or EC tablets. Consider holding tube feeding 1 hour before dose
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication: pantoprazole (ProtoNix)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Drug(s) proton-pump inhibitors
Rationale Risk of C. difficile infection, pneumonia, GI malignancies, bone loss, and fractures.
Recommendation Avoid scheduled use for >8 weeks unless for high-risk patients (e.g., oral corticosteroids or chronic NSAID use), erosive esophagitis, Barrett's esophagitis, pathologic hypersecretory condition, or demonstrated need for maintenance treatment (e.g., because of failure of drug discontinuation trial or H2-receptor antagonists).
 Quality of evidence: C. difficile, bone loss, and fractures: High
Pneumonia and GI malignancies: Moderate, Strength of Recommendation: Strong
Last updated: Sep. 19, 2025
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Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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