Prophylactic PPI's started in the hospital will be automatically discontinued when patients are discharged from ICU, unless there is a gastrointestinal indication for continuation.
Per policy, orders for these non-formulary agents will be changed to formulary equivalents.
Non-Formulary Agent
Formulary Equivalent
omeprazole (PriLOSEC) 10-40 mg PO
pantoprazole (Protonix) 40 mg PO at same frequency (esomeprazole (NexIUM) 40 mg packets if patient receives medication through a tube)
omeprazole (PriLOSEC) for pediatric patients
esomeprazole (NexIUM) granules - see for more details.
Enteral Drug Administration notes.
Generic (Brand)
Comments and Considerations
Recommendations for Administration with Enteral Nutrition
omeprazole (PriLOSEC)
Food may delay absorption and reduce bioavailability. Administration with liquid protein may result in a gas-producing reaction.
Substitute to esomeprazole delayed-release granules. Consider holding tube feeding for 1 hour before and after dose. Recommend alternative (esomeprazole). Hold liquid protein
(Brand)
(PriLOSEC)