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lansoprazole

lansoprazole
  • Restricted Medications Non-Formulary
Brand names: Prevacid
No brands, forms, or strengths have been added for this generic.
Display Proton-pump Inhibitors Class: 562836
Medication comments:

Per policy, orders for these non-formulary agents will be changed to formulary equivalents.  
Non-Formulary Agent Formulary Equivalent
lansoprazole (Prevacid) 15-30 mg PO pantoprazole (Protonix) 40 mg PO at same frequency (esomeprazole (NexIUM) 40 mg packets if patient receives medication through a tube)
lansoprazole (Prevacid) 30 mg IV pantoprazole (Protonix) 40 mg IV at same frequency
(see policy in the event of drug shortages.)
lansoprazole (Prevacid) for pediatric patients esomeprazole (NexIUM) granules - see for more details.
Enteral Drug Administration notes.
Generic
(Brand)		 Comments and Considerations Recommendations for Administration with Enteral Nutrition
lansoprazole
(Prevacid)		 Oral suspension granules - extremely viscous may cause occlusion Substitute to esomeprazole delayed-release granules. Do NOT administer oral suspension through feeding tube. May cause occlusion.
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication: lansoprazole (Prevacid)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Drug(s) proton-pump inhibitors
Rationale Risk of C. difficile infection, pneumonia, GI malignancies, bone loss, and fractures.
Recommendation Avoid scheduled use for >8 weeks unless for high-risk patients (e.g., oral corticosteroids or chronic NSAID use), erosive esophagitis, Barrett's esophagitis, pathologic hypersecretory condition, or demonstrated need for maintenance treatment (e.g., because of failure of drug discontinuation trial or H2-receptor antagonists).
 Quality of evidence: C. difficile, bone loss, and fractures: High
Pneumonia and GI malignancies: Moderate, Strength of Recommendation: Strong
Last updated: Sep. 19, 2025
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