Per policy, orders for these non-formulary agents will be changed to formulary equivalents.
Non-Formulary Agent
Formulary Equivalent
dexlansoprazole (Kapidex) 30-60 mg PO
pantoprazole (Protonix) 40 mg PO at same frequency (esomeprazole (NexIUM) 40 mg packets if patient receives medication through a tube)
dexlansoprazole (Kapidex) for pediatric patients
esomeprazole (NexIUM) granules - see for more details.
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication:
dexlansoprazole (Kapidex)
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Drug(s)
proton-pump inhibitors
Rationale
Risk of C. difficile infection, pneumonia, GI malignancies, bone loss, and fractures.
Recommendation
Avoid scheduled use for >8 weeks unless for high-risk patients (e.g., oral corticosteroids or chronic NSAID use), erosive esophagitis, Barrett's esophagitis, pathologic hypersecretory condition, or demonstrated need for maintenance treatment (e.g., because of failure of drug discontinuation trial or H2-receptor antagonists).
Quality of evidence: C. difficile, bone loss, and fractures: High Pneumonia and GI malignancies: Moderate, Strength of Recommendation: Strong
Pneumonia and GI malignancies: Moderate, Strength of Recommendation: Strong