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Integrilin Dosing Chart (by weight)
DOSAGE
- Bolus dose: 180mcg/kg (maximum 20mg) IV over 1-2 minutes (see
table below)
- Infusion: 2mcg/kg/minute (maximum 15mg/hr) for up to 72
hours (see table below). If the patient undergoes PTCA, the infusion
should continue through the procedure and for up to 24 hours
post-procedure.
- reduce maintenance dose by 50% (to 1mcg/kg/minute) in patients with
creatinine clearance < 50mL/min;
contraindicated if creatinine clearance < 20 mL/min
Eptifibatide dosing chart by weight (180mcg/kg bolus
and 2mcg/kg/min infusion):
|
Patient Weight (kg) |
Bolus Volume (mL) |
Infusion Rate (mL/hr) |
Infusion dose for creatinine
clearance <50mL/min or serum creatinine >
2.0mg/dL |
|
37-41 |
3.4 mL |
6 mL/hr |
3.0 mL/h |
|
42-46 |
4.0 mL |
7 mL/hr |
3.5 mL/h |
|
47-53 |
4.5 mL |
8 mL/hr |
4.0 mL/h |
|
54-59 |
5.0 mL |
9 mL/hr |
4.5 mL/h |
|
60-65 |
5.6 mL |
10 mL/hr |
5.0 mL/h |
|
66-71 |
6.2 mL |
11 mL/hr |
5.5 mL/h |
|
72-78 |
6.8 mL |
12 mL/hr |
6.0 mL/h |
|
79-84 |
7.3 mL |
13 mL/hr |
6.5mL/h |
|
85-90 |
7.9 mL |
14 mL/hr |
7.0mL/h |
|
91-96 |
8.5 mL |
15 mL/hr |
7.5mL/h |
|
97-103 |
9.0 mL |
16 mL/hr |
8.0mL/h |
|
104-109 |
9.5 mL |
17 mL/hr |
8.5mL/h |
|
110-115 |
10.0 mL |
18 mL/hr |
9.0mL/h |
|
116-121 |
10.0 mL |
19 mL/hr |
9.5mL/h |
|
>121 |
10.0 mL |
20 mL/hr |
10.0 mL/h |