FormWeb • Renal Dose Adjustments

Ampicillin
CrCl (ml/min)	Uncomplicated Infection	Meningitis or Endovascular infection
> 50	2 gm IV Q 6 hrs	2 gm IV Q 4 hrs
10-50	1 gm IV Q 6 hrs	2 gm IV Q 6 hrs
<10	1 gm IV Q 12 hrs	1 gm IV Q 8 hrs
HD	1-2 gm IV Q 12 hrs
CRRT	See CRRT dosing

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Ampicillin/Sulbactam (Unasyn®)
CrCl (ml/min)	Renal Adjustment
> 50	3 gm IV Q 6 hrs
10-50	1.5 gm IV Q 6 hrs
<10	1.5 gm IV Q 12 hrs
HD	1.5-3 gm IV Q 12 hrs
CRRT	See CRRT dosing

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Aztreonam (Azactam®)
CrCl (ml/min)	UTI	Systemic infection
≥ 30	1 gm IV Q 8 hrs	2 gm IV Q 8 hrs (q6h is OK in life threatening infections)
10-30	1 gm IV Q 12 hrs	2 gm IV Q 12 hrs
< 10	1 gm IV Q 24 hrs	1 gm IV Q 12 hrs
Hemodialysis	1 gm IV x 1 dose, then 1 g IV Q pm
CRRT	See CRRT dosing

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Baricitinib (Olumiant®)
Estimated glomerular filtration rate (eGFR)	Renal Adjustment
≥60 mL/min/1.73 m2	4 mg once daily
30 to 60 mL/min/1.73 m2	2 mg once daily
15 to 30 mL/min/1.73 m2	1 mg once daily
<15 mL/min/1.73 m2	Not recommended

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Cefazolin (Ancef^®)
CrCl (ml/min)	UTI (no sepsis); Uncomplicated ABSSSI	All other indications	Treatment of confirmed GNR from a non-urinary source and MIC > 2
> 30	1 gm IV Q 8 hrs	2 gm IV Q 8 hrs	Contact stewardship pharmacist as cefazolin may not be the best drug for the patient
10-30	1 gm IV Q 12 hrs	2 gm IV Q 12 hrs
<10	1 gm IV Q 24 hrs
HD	1 gm IV Q PM (For outpatient use: 2 gm IV post-HD only)
CRRT	See CRRT dosing

Note: The MIC > 2 comment in the last column only applies to gram-negative infections.
Continue using the dosing strategies listed in the first two columns for gram-positive infections.
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Cefepime (Maxipime®)
CrCl (ml/min)	Febrile Neutropenia or Treatment of recent or confirmed infection with a GNR with an MIC of 8, critically ill with BMI ≥ 30	UTI, no sepsis	All other indications
> 50	2 gm Q 8 hrs	1 gm Q 12 hrs	1 gm Q 6 hrs
30-49	2 gm Q 12 hrs	1 gm Q 24 hrs	1 gm Q 8 hrs
11-29	2 gm Q 24 hrs	1 gm Q 24 hrs	1 gm Q 12 hrs
≤ 10 or HD	1 gm Q PM (give after dialysis)
CRRT	See CRRT dosing

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Cefoxitin (Mefoxin®)
CrCl (ml/min)	Uncomplicated	Moderate to Severe Infection
≥ 50	1 gm IV Q 6 hrs	2 gm IV Q 6 hrs (doses up to 2g IV q4h or 3g IV q6h have been used)
30-49	1 gm IV Q 8 hrs	2 gm IV Q 8 hrs
10-29	1 gm IV Q 12 hrs	2 gm IV Q 12 hrs
< 10	0.5 gm IV Q 24 hrs	1 gm IV Q 24 hrs
Hemodialysis	2 gm IV x 1 dose, then 1 g IV Q pm
CRRT	1-2 gm IV Q 8 hrs

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Ceftaroline (Teflaro®)
CrCl (ml/min)	Uncomplicated Infection	Pneumonia, Severe Infections
> 50	600 mg IV Q 12 hrs	600 mg IV Q 8 hrs
30-50	400 mg IV Q 12 hrs	600 mg IV Q 12 hrs
15-29	300 mg IV Q 12 hrs	400 mg IV Q 12 hrs
<15 or HD	200-300mg IV Q 12 hrs
CRRT	See CRRT dosing

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Ceftazidime/Avibactam (Avycaz®)
CrCl (ml/min)	Renal Adjustment
> 50	2.5 gm IV Q 8 hrs
31-50	1.25 gm IV Q 8 hrs
16-30	0.94 gm IV Q 12 hrs
6-15	0.94 gm IV Q 24 hrs
≤ 5 or HD	0.94 gm IV Q 48 hrs
CRRT	See CRRT dosing

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Ceftolozane/Tazobactam (Zerbaxa®)
CrCl (ml/min)	Uncomplicated Infection	Pneumonia, Severe Infections
> 50	1.5 gm IV Q 8 hrs	3 gm IV Q 8 hrs
30-50	750 mg IV Q 8 hrs	1.5 gm IV Q 8 hrs
15-29	375 mg IV Q 8 hrs	750 mg IV Q 8 hrs
HD	750 mg IV x 1 dose, then 150mg IV q8h	2.25g IV x 1 dose, then 450mg IV q8h
CRRT	See CRRT dosing

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Ciprofloxacin (Cipro®)
CrCl (ml/min)	Renal Adjustment
≥ 30	500 mg PO Q 12 hrs, 400 mg IV Q 12 hrs
< 30	500 mg PO once daily 400 mg IV once daily
Hemodialysis	500 mg PO once daily 400 mg IV once daily On dialysis days, give after dialysis.
CRRT	See CRRT dosing

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Clindamycin (Cleocin®) IV
Standard Dose	600 mg IV Q 8 hrs	No adjustment for renal dysfunction
Necrotizing fasciitis	900 mg IV Q 8 hrs

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Enoxaparin (Lovenox®)
CrCl (ml/min)	Prophylactic Dose	Treatment Dose
≥ 30	40 mg daily	1 mg/kg BID*
< 30	30 mg daily	1 mg/kg daily*

* If CrCl < 20 ml/min and on treatment dose, dose will be decreased to once daily and
anti-factor Xa level drawn 4 hours post-dose to evaluate if continued Lovenox use is appropriate.

* If patient weight > 190 kg and on treatment dose, pharmacy will automatically
obtain anti-factor Xa level 4 hours post-dose.
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Famotidine (Pepcid®)
CrCl (ml/min)	Renal Adjustment
≥ 50	20 mg PO/IV BID
< 50	20 mg PO/IV daily

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Fluconazole (Diflucan) – IV only Low dose IV fluconazole (< 200 mg) will be interchanged to the smallest commercially available bag (200 mg) when oral formulation is not an option.
CrCl (ml/min)	Renal Adjustment
> 10	< 200 mg IV daily ordered & Tablet or Suspension is not an option due to intolerability or questionable GI absorption	200 mg IV daily
Hemodialysis		400 mg IV post-HD only

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Fondaparinux (Arixtra®)
(contraindicated in patients with CrCl < 30 ml/min)

For patients with CrCl < 30 ml/minute who are on the prophylactic dose of Arixtra (2.5 mg daily), pharmacy will automatically change to Lovenox 30 mg daily.

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Levofloxacin (Levaquin®) Pertains to IV or PO dosing.
CrCl (ml/min)	Initial Dose	Subsequent Doses
≥ 50	750 mg	750 mg q 24 hrs
20-49	750 mg	750 mg q 48 hrs
10-19	750 mg	500 mg q 48 hrs
Hemodialysis	750 mg	500 mg q 48 hrs
CRRT	See CRRT dosing

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Meropenem (Merrem®)
Creatinine clearance (ml/min)	Treatment of confirmed or recent infection with Acinetobacter or Pseudomonas with MIC >2	All other diagnoses
> 50	1 gm IV q 8 hrs (over 3 hrs)	500 mg IV q 6 hrs
26 – 50	1 gm IV q 12 hrs (over 3 hrs)	500 mg IV q 8 hrs
10 – 25	500 mg IV q 12 hrs	500 mg IV q 12 hrs
< 10	500 mg IV daily	500 mg IV daily
Hemodialysis	500 mg IV QPM (1800) On dialysis days, give after dialysis.	500 mg IV QPM (1800) On dialysis days, give after dialysis.
CRRT	See CRRT dosing

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Meropenem/vaborbactam (Vabomere®)
eGFR (ml/min/1.73m)	Renal Adjustment
≥ 50	4 gm IV q 8 hrs
30 – 49	2 gm IV q 8 hrs
15 – 29	2 gm IV q 12 hrs
< 15 or HD	1 gm IV q 12 hrs
CRRT	See CRRT dosing

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Oseltamivir (Tamiflu®)
CrCl (ml/min)	Renal Adjustment
> 60	75 mg BID
30 – 60	75 mg DAILY
< 30	30 mg DAILY
CRRT	75 mg BID
Hemodialysis	30 mg post HD only (initial dose may be given immediately with subsequent doses after each dialysis)

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Piperacillin/Tazobactam (Zosyn®) Extended Infusion Pharmacy will adjust all doses to extended infusion as outlined below.
Piperacillin/Tazobactam (Zosyn®)	Loading Dose	BMI < 30	BMI ≥ 30
CrCl > 20 ml/min or CRRT	4.5 gm IV x 1 dose (30min infusion), followed by BMI based dosing strategy	3.375 gm IV q 8 hrs (4 hour infusion)	4.5 gm IV q 8 hrs (4 hour infusion)
CrCl ≤ 20 or HD or peritoneal dialysis		3.375 gm IV q 12 hrs (4 hour infusion)
CRRT	See CRRT dosing

Piperacillin/Tazobactam (Zosyn®) Standard Infusion Standard Infusion will only be used when IV compatibility/line access issues preclude the use of extended infusion.
CrCl (ml/min)	All Other Indications	Nosocomial Pneumonia
> 40	3.375 gm IV Q 6 hrs	4.5 gm IV Q 6 hrs
20 – 40	2.25 gm IV Q 6 hrs	3.375 gm IV Q 6 hrs
< 20	2.25 gm IV Q 8 hrs	2.25 gm IV Q 6 hrs
Hemodialysis	2.25 gm IV Q 12 hrs + 0.75 gm after each dialysis session	2.25 gm IV Q 8 hrs + 0.75 gm after each dialysis session
CAPD	2.25 gm IV Q 12 hrs no additional bolus dose	2.25 gm IV Q 8 hrs no additional bolus dose

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Drug	Loading Dose	Maintenance Dosage for CRRT			High Dose*
Drug	Loading Dose	CVVH	CVVHD	CVVHDF	High Dose*
Ampicillin	2g	1-2g q8-12h	1-2g q8h	1-2g q6-8h	2g q4-6h
Ampicillin/sulbactam	3g	1.5-3g q8-12h	1.5-3g q8h	1.5-3g q6-8h	3g q6h
Aztreonam	2g	1-2g q12h	1g q8h or 2g q12h	1g q8h or 2g q12h	2g q8h
Cefazolin	2g	1-2g q12h	1g q8h or 2g q12h	1g q8h or 2g q12h	2g q8h
Cefepime	2g	1-2g q12h	1g q8h or 2g q12h	1g q8h or 2g q12h	1g q6h or 2g q8h
Ceftaroline	600mg	400-600mg q12h			600mg q8h
Ceftazidime/avibactam	2.5g	1.25g IVq8h			2.5g q8h (based on ceftazidime data)
Ceftolozane/tazobactam	3g	750mg q8h	1.5g q8h	1.5g q8h	1.5g q8h (data lacking for higher dose)
Ciprofloxacin	N/A	400mg q12-24h	400mg q12-24h	400mg q12h	400mg q8-12h
Levofloxacin	750mg	750mg q48h	750mg q48h	750mg q24h	750mg q24h
Meropenem	1g	500mg-1g q12h	500mg q8h/1g q12h	500mg q8h/1g q12h	500mg q6h/1g q8h
Meropenem/vaborbactam	4g	1-2g q8h (extended)			2g q8h (extended); based on meropenem data
Piperacillin/tazobactam	4.5g	3.375-4.5g IV q8h (extended)

*Parameters

· Ultrafiltration/dialysate flow rate of > 2 L/hr

· Residual renal function

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Acyclovir (Zovirax®) IV dosing only Use IBW; if TBW >20% IBW, use adjBW
CrCl (ml/min)	HSV encephalitis/Herpes zoster	Herpes simplex infections	Prevention of HSV/VZV when unable to tolerate PO
> 50	10mg/kg/dose IV q8h	5mg/kg/dose IV q8h	5mg/kg/dose IV q12
25-50 or CRRT	10mg/kg/dose IV q12h	5mg/kg/dose IV q12h	5mg/kg/dose IV q24
10-24	10mg/kg/dose IV q24h	5mg/kg/dose IV q24h	2.5mg/kg/dose IV q24h
<10 or HD	5mg/kg/dose IV q24h	2.5mg/kg/dose IV q24h	2.5mg/kg/dose IV q24h

* Please clarify indication with provider prior to selecting a dosing strategy

** When transitioning a patient from PO valacyclovir to IV acyclovir, please consider this conversion: Valacyclovir 1,000mg PO TID à Acyclovir 5mg/kg/dose IV q8h
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Apixaban (Eliquis®)
Nonvalvular Atrial Fibrillation

Normal Dose

5 mg BID
(may be taken without regard to food)

TWO of the following:
Age ≥ 80 years
Body weight ≤ 60 kg
Serum creatinine ≥ 1.5

2.5 mg BID
(may be taken without regard to food)

Apixaban (Eliquis®) Postoperative Thromboprophylaxis (Knee or Hip)
Normal Dose	2.5 mg BID
Initiate therapy after hemostasis established (~12-24 hours post-op). Use for 12 days for knee replacement. Use for 35 days for hip replacement.

Apixaban (Eliquis®) DVT/PE Treatment
Treatment Dose	10 mg BID x 7 days, then 5 mg BID.
Reduction in the risk of recurrence	2.5 mg BID after at least 6 months of treatment for DVT/PE.
Dose adjustment: None necessary; however, patients with a SCr > 2.5 or CrCl < 25 were excluded from the clinical trials.

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Dabigatran (Pradaxa®) Nonvalvular Atrial Fibrillation
CrCl (ml/min)	Recommended Dose
> 30	150 mg BID
15-30	75 mg BID
< 15 or HD patient	Not recommended

Dabigatran (Pradaxa®) DVT/PE Treatment
CrCl (ml/min)	Recommended Dose
> 30	Parenteral anticoagulant x 5-10 days, then 150 mg BID
< 50 + PGP inhibitors	Avoid Use
< 30 or HD patient	Avoid Use (not studied)

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Edoxaban (Savaysa®) Nonvalvular Atrial Fibrillation
CrCl (ml/min)	Recommended Dose
> 95	Avoid Use Increased risk of ischemic stroke compared to warfarin
51-95	60 mg daily
15-50	30 mg daily
< 15 or HD patient	Avoid Use

Edoxaban (Savaysa®) DVT/PE Treatment
CrCl (ml/min)	Recommended Dose
> 50	Parenteral anticoagulant x 5-10 days, then 60 mg daily if weight > 60 kg 30 mg daily if weight ≤ 60 kg
> 50 + PGP inhibitor (verapamil, quinidine, or short-term use azithromycin, clarithromycin, erythromycin, itraconazole, ketoconazole)	30 mg daily
15-50	Parenteral anticoagulant x 5-10 days, then 30 mg daily
< 15 or HD patient	Avoid Use

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Rivaroxaban (Xarelto®) Nonvalvular Atrial Fibrillation
CrCl (ml/min)	Recommended Dose
> 50	20 mg daily (with evening meal)
15-50	15 mg daily (with evening meal)
< 15 or HD patient	Avoid Use

Rivaroxaban (Xarelto®) Postoperative Thromboprophylaxis
CrCl (ml/min)	Recommended Dose
> 30	10 mg daily
< 30	Avoid Use
Initiate therapy after hemostasis established (~10 hours post-op). Use for 12-14 days for knee replacement. Use for 35 days for hip replacement.

Rivaroxaban (Xarelto®) DVT/PE Treatment
CrCl (ml/min)	Recommended Dose
> 30	15 mg BID x 21 days, then 20 mg daily (with food)
< 30	Avoid Use

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Pharmacy Phone Numbers
Memorial Pharmacy (Glenwood) 423-495-8380
Memorial Hixson Pharmacy 423-495-7137
Stat 423-495-7470
Outpatient 423-495-8981
Chemo 423-495-7475
Surgery 423-495-8779

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