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Vancomycin Single Level Adjustment Background Info:
- A new Ke is calculated using the following equation:
|
Ke = |
ln[(dose/Vd
+ Trough)/Trough] |
|
Dose Interval |
- When you enter a New Dose & Interval, a peak is extrapolated:
|
Predicted Pk
= |
Dose * (1 - e (-Ke * infusion time) ) |
|
Ke * Vd * inf time * (1 - e (-Ke *
dose interval) ) |
- The extrapolated peak is then used to determine a trough with the same Ke:
|
Predicted Trough = |
Pred Pk * e
(-Ke * (Dose interval - inf
time) ) |
|
- NOTE: In the above equations, “Dose Interval" = "Current Interval" - "Minutes Drawn Before Dose". E.g. if the interval is 12 hours and the level is drawn 30 minutes before the dose, it will use 11.5 hours as the "Dose Interval".