nizatidine
| Per policy, orders for these non-formulary agents will be changed to formulary equivalents. | |
|---|---|
| Non-Formulary Agent | Formulary Equivalent |
| nizatidine (Axid) | famotidine (Pepcid) 20 mg, subject to renal dosing adjustments by pharmacy (see famotidine for more info) famotidine (Pepcid) liquid for pediatric patients |
| 2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults. | |
|---|---|
| Medication: | nizatidine (Axid) |
| Criteria 2: Potentially inappropriate medication use in older adults due to drug–disease or drug–syndrome interactions that may exacerbate the disease or syndrome. (Table 3) | |
| Drug(s) ⇆ disease or syndrome | H2-receptor antagonists ⇄ Delirium |
| Rationale | Avoid in older adults with or at high risk of delirium because of the potential of inducing or worsening delirium. |
| Recommendation | Avoid |
| Quality of evidence: Low, Strength of Recommendation: Strong | |
| Criteria 5: medications that should be avoided or have their dosage reduced with varying levels of kidney function in older adults. (Table 6) | |
| CrCl (mL/min) at which action is required | <50 |
| Rationale | Mental status changes |
| Recommendation | Reduce dose |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |