Following is a P and T Committee update (from the July 26th meeting). Starting date for specific programs is 1 Aug 2016, unless otherwise noted. Please let me know if you have any questions or comments. Don’t forget to check the “New Drug Monitoring Spotlight” section of the website, which provides important monitoring information about newly approved drugs. Also, attached is the updated version of the “Not Stocked, Not Ordered” drug list with the new additions highlighted in red.
Below is the memo with links to the drug monographs, protocols, and formulary documents. Click to access the full P&T packet for this month, or here to access the P&T packet archive.
Drug or Drug Class |
Formulary Decision |
Comments |
uridine triacetate (Vistogard) | Formulary, Restricted (Not Routinely Stocked) |
Restricted to oncology for the treatment of adult and pediatric patients following a fluorouracil or capecitabine overdose or those with early onset (< 96 hrs) severe or lifethreatening toxicity from these agents. Available to hospital within 24 hrs. |
venetoclax (Venclexta) | Non-Formulary | Inpatients may use home supply. |
methylphenidate (Quillichew ER) | Non-Formulary Automatic Interchange Approved | Automatic interchange to generic methylphenidate ER product at approximately 1:1 dose at the same dosing interval. |
codeine polistirex-chlorpheniramine polistirex (Tuzistra ER Suspension) | Non-Formulary Automatic Interchange Approved |
Automatic interchange to Tussionex PennKinetic Liquid. Tuzistra XR 10 mL is equivalent to Tussionex 3 mL. |
flibinersin (Addyi) | Non-Formulary |
Physicians must undergo a special training program and be certified to prescribe Addyi. Therapy should not be continued in the hospital. Clinical trials show no evidence of adverse events following abrupt discontinuation. |
tofacitinib citrate (Xeljanz XR) | Non-formulary | Inpatients may use home supply. |
Pre-Procedure Orders – Pain Center | Protocol Approved | Pending further review by other institutional committees. |
docusate liquid update | Informational HH Stock Sequestered |
Due to a multi-state outbreak of infections caused by Burkholderia cepacia complex, the CDC has recommended clinicians avoid use of any liquid docusate products in all patients. Previously, the CDC had recommended avoiding in immunocompromised or critically ill patients. |
initiation of IV fluids in procedural areas | Policy Approved |
Upon receipt of a physician’s order, approved clinical staff may initiate IV access and infuse up to liter of IV fluids as ordered prior to pharmacist verification. A risk analysis completed on July 25, 2016 led to the conclusion that this was a low risk process. |
heparinization during dialysis | Policy Revisions Approved |
Policies updated to specify loading doses and as needed bolus doses of heparin administered into the dialysis circuit. A risk analysis completed on July 26, 2016 discussing storage and use of heparin during dialysis led to the conclusion this was a low risk process. |
3% hypertonic saline infusion policy | Policy Approved |
The policy outlines dosing, dispensing, and administration restrictions and requirements. CRNPs, PAs, or medical residents/interns may not order IV hypertonic saline. Nephrology must be consulted for follow-up of hyponatremia management in adult patients initiated on hypertonic saline. |
duplicate medication orders policy | Policy Revisions Approved | Policy updated and expanded to include automatic pharmacist discontinuation and/or adjustment of indications for PRN pain orders with duplicate indications in numerous situations. |
Approved Compounding Facilities | Facilities Approved: Advanced Infusion Solutions CAPS – Allentown, PA PharMEDium SCA Pharmaceuticals QuVa | Advanced Infusion Solutions (AIS) approved for pain pumps for Pain Center patients. |
hazardous drugs policy | Policy Reviewed & Approved | Hazardous drug list approved. |
High-Risk, High-Alert Policy | Policy Reviewed & Approved | High-Risk, High-Alert drug lists for Adults, Pediatrics, and Neonatal approved. |
ADE Report | Informational | 142 ADEs were reported in May-June 2016. 11 (7.8%) were classified as preventable and commonly associated with hypoglycemia. Vancomycin, radiological contrast media, methylPREDnisolone, and levofloxacin were the 4 most common drugs associated with ADEs. |