P&T Committee-OLD

P&T Policy

Please use the following form to request a medication addition to the formulary. All forms may be emailed to Britney.Mellor@fmolhs.org

The following form should be used for outpatient non-formulary requests ONLY:

For pharmacy use only:

2022

February

(System P&T)

Kcentra will remain formulary with the following fixed dosing strategy

  • Warfarin related life-threatening bleeding-1500 units
  • Anti-Xa related life-threatening bleeding-2000 units

Idarucizumab (Praxbind) added to system formulary

  • Each market to determine formulary status

Andexanet alfa (Andexxa) reviewed and NOT approved for formulary addition

Drug Class Reviews

January

(System P&T)

Oxacillin added to formulary, nafcillin removed from formulary.

Meropenem dose buttons added in Epic

Drug classes reviewed:

  • Bone Resorption Inhibitors
  • P2Y12 Inhibitors

Calcitonin restriction criteria discussed and approved

2021

December

Bupivacaine-meloxicam (Zynrelef) added to formulary

Liposomal bupivacaine (Exparel) dosing and preparation guidelines reviewed

The following pharmacy protocol updates were approved:

  • Vancomycin
  • Aminoglycoside 
  • Dose rounding

Meropenem will include a hard stop for prescribers to select an indication button in Epic

Methotrexate oral will default to a weekly frequency; daily frequency will require a hard stop in Epic to confirm an appropriate oncologic indication, per ISMP Best Practices

Request to restrict injectable promethazine to PACU, ED, and Oncology ordersets only, per ISMP Best Practices, was NOT approved

December

(System P&T)

Ubrogepant (Ubrelvy) reviewed and NOT approved for formulary addition

Appeals:

Drug classes reviewed:

  • Tricyclic Antidepressants (TCAs)
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Atypical Antipsychotics, injectables
  • Atypical Antipsychotics, oral/topical
  • Typical Antipsychotics, oral
  • Phosphodiesterase Type 5 (PDE-5) Inhibitors
  • Phosphodiesterase (PDE) Inhibitors, Nonselective
  • Ophthalmic Antimicrobials
  • Ophthalmic Corticosteroids

Approved vaccine appeals:

October

(System P&T)

Formulary addition request form presented and approved

Ubrogepant (Ubrelvy) reviewed; approval pending further review

Enfortumab vedotin (Padcev) reviewed and approved for outpatient use only

Appeals:

  • Empagliflozin (Jardiance) new indications reviewed; approval pending further review
  • IV acetaminophen (Ofirmev) reviewed and current restrictions remain

Drug classes reviewed:

  • Thrombolytics
  • Antidepressants 
    • Noradrenergic and Specific Serotonin Reuptake Inhibitors
    • Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs)
    • Selective Serotonin Reuptake Inhibitors (SSRIs)
  • Non-depolarizing Neuromuscular Blockers
  • Hepatitis B Immune Globulins

October

Enfortumab vedotin (Padcev) was reviewed and added to formulary, restricted to outpatient use only

Avelumab (Bavencio) dosing updated to include 800 mg flat dose

Inpatient pegfilgrastim MUE presented with no changes to formulary status or criteria for use. Consider annual MUE due to cost. 

Lanreotide 60 mg and 90 mg strengths added to formulary, restricted to outpatient use only approved by consent agenda 

September

(System P&T)

Bupivacaine-collagen implant (Xaracoll) reviewed and added to formulary for FDA-approved indications only

Prevnar-20 reviewed and approved as substitution for Prevnar-13

Pegfilgrastim-apgf (Nyvepria) reviewed and approved for outpatient use only

Drug classes reviewed:

  • Antiviral Agents
  • Antiviral Topical Agents
  • Amphotericin B 
  • Thyroid Agents
  • Glycoprotein IIb/IIIa Inhibitors
  • Pegfilgrastim, biosimilar updates

August

(System P&T)

Aducanumab (Aduhelm) reviewed and NOT added to system formulary

Following vaccine appeals were approved:

  • Menveo will be formulary. Menactra will be non-formulary
  • Havrix will be formular. Vaqta will be non-formulary

Therapeutic substitutions were presented and approved

Drug classes reviewed:

  • Trastuzumab, biosimilars
  • Bevacizumab, biosimilars
  • Infiximab, biosimilars
  • Rituximab, biosimilars

August

Aducanumab (Aduhelm) reviewed and NOT added to OLOL formulary

Pertuzumab, trastuzumab, and hyaluronidase (Phesgo) was reviewed and added to formulary, restricted to outpatient setting only

Medication Samples in Provider-Based Clinics was reviewed and approved

Vancomycin 6 month safety review was discussed

Renal dosing policy and protocol were approved by consent agenda

July

(System P&T)

Ofirmev restriction approved:

  • restricted to first 24 hours in surgeries as part of an ERAS protocol
  • PDA in the pediatric population

Kayexalate oral appeal was made to expand restriction criteria to NPO in the pediatric population

Zofran max dose was reduced from 32 mg to 16 mg in accordance with the FDA recommendations

Drug classes reviewed:

  • SGLT2 Inhibitors
  • LMWH
  • Fondaparinux
  • Filgrastim, biosimilars
  • Pegfilgrastim, biosimilars
  • Erythropoiesis stimulating agents, biosimilars

June

(System P&T)

Anavip approved as sole formulary antivenom

Drug classes reviewed:

  • Analgesics and antipyretics
  • Opiate agonists
  • Opiate partial agonists
  • NSAIDs
  • Direct Thrombin Inhibitor/Factor Xa Inhibitor

All oral antihyperglycemic medications will be removed from formulary except in the follow situations (see attached):

  • Mental health units
  • Outpatients and patients undergoing 23-observation stays
  • Patients receiving oral anti-hyperglycemic agents for non-type II diabetes mellitus indications
  • Patients <18 years of age
  • Labor and delivery
  • Post-acute care units
  • Antepartum unit

All inpatients, except those listed above will be converted to insulin therapy

Oral Antihyperglycemic Conversion to Insulin Recommendations

June

Cefepime added to outpatient formulary

Respiratory formulary reviewed. Additions to respiratory formulary include:

  • Amikacin
  • Tranexamic acid
  • Colistin

Therapeutic interchange approved for Metamucil to Fibercon and mineral oil 300mL enema to mineral oil 266ml enema

IV to PO Policy and Clozapine Policy reviewed and updated

May

(System P&T)

Drug classes reviewed:

  • Antihistamines
  • Antihyperglycemics
  • Insulins

April

Trastuzumab biosimilars reviewed. Ogivri approved as preferred agent for both inpatinent and outpatient settings (see Biosimilar and reference product interchange list)

Ofirmev approved through the Improving Surgical Care and Recovery Pathway workgroups will be approved by the P&T committee via consent agenda moving forward

Tacrolimus Pharmacy Monitoring Protocol approved. Start date TBD

Restrictions removed from tranexamic acid. All formulations approved for formulary

Alum 1% reviewed and NOT added to formulary

Tafasitamab-cxix (Monjuvi) added to formulary, restricted to outpatient setting only

February

Caplacizumab (Cablivi) added to formulary, restricted to hematology/oncology and nephrology

Acetaminophen (Ofirmev) restriction expended to include Head & Neck ERAS

Pegfilgrastim formulary status changed. Fulphila is inpatient formulary preferred agent. Added to inpatient formulary with following restriction criteria:

  • Prescribed by hematology/oncology providers
  • Patient received myelosuppressive therapy within 24-72 hours prior to pegfilgrastim therapy
  • Patient will not be able to receive pegfilgrastim injection in outpatient setting 24-72 hours after completion of anticancer therapy but is anticipated to be discharged within 5 days after anticancer therapy

Filgrastim (Granix) formulary status changed. Granix is now preferred formulary agent.

Lutetium Lu-177 Dotate (Lutathera) process map approved. Formulary changes specifically related to Lutathera include:

  • Pre-medication with special amino acid solution for use only with Lutathera treatment
  • Long acting octreotide approved for same day use with Lutathera treatment

Tacrolimus medication use evaluation presented. Pharmacy to develop a monitoring protocol for presentation at April P&T meeting.

2020

December

Lipid emulsion (SMOF Lipid) added to formulary for expanded use in adults (previously only used in pediatrics)

Carbidopa/Levodopa Extended Release (Rytary) added to formulary

Infliximab-abda (Renflexis) added to formulary as the preferred inpatient and outpatient product

Updated Biosimilar Protocol approved

Updated Dose Rounding Protocol approved

Updated Pharmacist Managed Warfarin Dosing Policy approved

Daratumumab/hyaluronidase (Darzalex Faspro) added to forumlary and restircted to OUTPATIENT use only

October

Moxifloxacin (Avalox) added to formulary and restricted to Critical Care/Pulmonology or Infectious Diseases physicians for the use in mycobacterial infections ONLY

Exparel restriction criteria expanded to Head and Neck surgery

Poractant alfa (Curosurf) added to formulary for use in the NICU ONLY

Cannabidiol (Epidiolex) added to formulary at the Children's Hospital ONLY and restricted to continuation of home medication

Sacituzumab govitecan-hziy (Trodelvy) added to formulary and restricted to OUTPATIENT use only

Epoprostenol (Veletri) formulary interchange approved

Crizanlizumab (Adakveo) added to formulary and restricted to OUTPATIENT use only

Removed from formulary:

  • Cangrelor (Kengreal)

August

Meropenem/Vaborbactam (Vabomere) added to formulary and restricted to ordering by an Infectious Diseases provider

Polatuzumab vedotin (Polivy) added to formulary

Topical antifungals reviewed and formulary streamlined (Formweb updated)

Updated Renal Dosing Protocol approved

Updated Biosimilary Policy approved

June

Addition of non-acetaminophen induced acute liver injury (NAI-ALI) added as an approved indication of intravenous acetylcysteine

Truxima (rituximab-abbs) approved as the preferred inpatient and outpatient formulary agent for rituximab and rituxima biosimilars

Updated Aminoglycoside Pharmacokinetic Protocol approved

Updated Fomularly Management Policy approved

Pharmacy to automatically monitor anti-Xa levels in morbidly obese patients approved

Ultomiris added to formulary, restricted to outpatient only

 

February

 

Eravacycline (Xerava) added to formulary and restricted to ordering by Critical Care providers for specific indications (see monograph on Formweb) and Infectious Disease providers

Advate was deleted from formulary. Use Humate-P if factor VIII is needed

Fixed-dose Kcentra approved for use in anti-Xa related life-threatening bleeding in addition to warfarin-related life-threatening bleeding

Phenylephrine and ketorolac ophthalmic injection (Omidria) was not approved

2019

December

Blinatumomab (Blincyto) added to formulary and restricted to FDA approved indications of acute lymphoblastic leukemia (B-cell precursor)

Heplisav-B added to formulary as preferred Hepatitis B vaccine

Updated Vancomycin Pharmacokinetic Protocol approved

Probiotic therapeutic interchange to Culterelle approved

Acebutolol therapeutic interchange to atenolol approved

November

(System P&T)

IVIG dosing based on IBW or adj BW if patient is >20% above IBW was approved

October

68ga-dotatate (NETSPOT) reviewed. Tabled for next meeting after review by oncology service-line committee

Synthetic Human Secretin added to formulary

Bevacizumab-awwb (Mvasi) added to formulary-restricted to new outpatient starts only

Trastuzumab-anns (Kanjinti) added to formulary-restrictioned to outpatient only

ANAVIP reviewed and added to formulary in addition to, not replacement for Crofab. Process to be developed for envenomations

August

Liposomal daunorubicin and cytarabine (Vyxeos) added to formulary**

Ceftolozane/tazobactam (Zerbaxa) added to formulary and restricted to ID provider for use in treatment of MDR Pseudomonas aeruginosa

Ceftazidime/Avibactam (Avycaz) added to formulary and restricted to ID providers for the treatment of CRE and MDR Pseudomonas aeruginosa resistant to Zerbaxa

Esketamine (Spravato) reviewed. Decision tabled until defined process is in place

Cetuximab and Vectibix added to Medications Restricted to Outpatient List

June

Sodium Zirconium Cyclosilicate (Lokelma) added to formulary

Nebivolol (Bystolic) REMOVED from formulary. Therapeutic interchanged to atenolol

April

Cangrelor (Kangreal) added to formulary. Restricted to interventional cardiology and only used in patients with no enteral access requiring emergency PCI

Kcentra fixed dosing strategy for warfarin-related life threatening bleeding was approved

February

Glucarpidase (Voraxaze) added to formulary with restrictions to inpatient use

Meningococcal Group B Vaccine (Bexsero) added to formulary

Perflutren Protein-Type A Microspheres (Optison) reviewed. Addition tabled

Perampanel (Fycompa) reviewed and added for use only as a home medication, no new starts

 2018

December

Melatonin 3 mg and 5 mg ODT added to formulary

Acetaminophen IV (Ofirmev) approved for use in colorectal surgery

Belinostat (Beleodaq), Durvalumab (Imfinzi), Valrubicin (Valstar) approved for use in outpatient setting only

October

ERAS Supplements, Kate Farms products, PediaSure Harvest, and KetoCal added to the Nutrition Care Formulary

Andexanet alfa (Andexxa) added to formulary; has since been removed from formulary

Glargine pen (Basaglar Pen) was reviewed and NOT added to formulary

Rituximab/Hyaluronidase (Rituxan Hycela) and Aprepitant (Cinvanti) Injection added to formulary

Removed from formulary:

Buprenorphine 0.3 mg/1 ml; Buprenorphine/Naloxone 8 mg-2 mg  film; Butabarbital Sodium 30 mg tab; Butorphanol spray; non-aerosol  10 mg/2.5 ml; Clonazepam disintegrating 0.125 mg tab; Fiorinal with Codeine capsule; Guaifen/Pseud 100 mg- 30 mg/5 ml syrup; Methohexital (Brevital) 500 mg inj; Morphine 30 mg capsule (Avinza);

Oxycodone ER 80 mg tab; Pseudoephedrine ER 120 mg tablet; Pseudoephedrine 60 mg tablet

June

CVT received approval for implementation of ERAS Protocol with 6 doses of Ofirmev permited to be given post-op if the first dose was given intra-op

April

Removed from formulary:

  • Konsyl (psyllium) packet
  • Vexol (remexolone) 1% 5 mL Ophthalmic Suspension
  • Glyoxide (carbamide peroxide) 10% 2 oz bottle

February

Inflectra (infliximab-dybb) added to formulary

 
 2017

December

Infliximab-dyyb (Inflectra) reviewed

Dantrolene (Ryanodex) reviewed

October

Sodium, potassium, and magnesium sulfate (Suprep) added to the formulary

Depocyte (liposomal cytarabine) REMOVED from formulary

September

No medication changes

August

Sacubitril/valsartan (Entresto) restriction expanded from Cardiology only to now include Internal Medicine/HMS for inpatient and outpatient utilization

June

IV Prochlorperazine reviewed and added to formulary for the acute management of migraines in the ED for only 2 doses

April

Nusinersen (Spinraza) reviewed and deferred to System P&T

February

Veltassa approved for inpatient use and utilization to be reviewed in 6 months

Nitroglycerin Sublingual Sprays REMOVED from formulary

 2016

December

No medication changes

October

Venofer REMOVED from formulary

September

Dexmedetomidine ordering privileges restricted to CCMS, LSU ICU, Trauma, CVT, ED, Anesthesiology

June

 

Veltassa reviewed and NOT added to formulary

Triamterent (Dyrenium) REMOVED from formulary

IV-to PO Protocol: Cefdinir and Voriconazole added to Opportunities for Step-Down Therapy

April

Sugammadex (Bridion) added to formulary for OR use only

Veltassa reviewed and NOT added to formulary

Removed from formulary:

  • Lansoprazole (Prevacid) solutabs and capsules
  • Esomeprazole (Nexium) injection and packets

Modifications of Dofetilide (Tikosyn) administration policy approved

March

Lantus replaced Levemir as preferred long-acting insulin

Methocarbamol added to the IV-to-PO drug list

February

Clevidipine (Cleviprex) added to formulary

Sucroferric oxyhydroxide (Velphoro) added to formulary

  • Sevelemer carbonate tablets and powder for oral suspension RESTRICTED to pediatric and adult patients unable to tolerate Velphoro

Sodium Tetradecyl Sulfate (Sotradecol) added to formulary with restrictions to severe bleeding secondary to esophageal varices that have failed other treatments

IV Acetaminophen (Ofirmev) approved for use in Robotic Heart Surgery patients given in the following manner:

  • One dose post-op only if first dose was given in intraoperative period
  • The dose must be ordered through the Robotic Heart order set

Ketamine Policy & Protocol: removed restriction from the location of palliative care patient

Automatic IV-to-PO Protocol: Keppra(levetiracetam) and Vimpat(lacosamide) added

January

Naloxogel (Movantik) added to formulary with restrictions to patients with opioid-induced constipation that have failed two or more laxatives

  • Methylnatrexone RESTICTED to palliative and oncology NPO patients
  • Lubiprostone REMOVED from formulary

Belatacept (Nulojix) added to formulary with restrictions to outpatient use for EBV seropositive patients receiving a kidney transplant

Idarucizumab (Praxbind) added to formulary


Pharmacy Phone Numbers
Our Lady of the Lake Regional Medical Center
225-765-4434
Our Lady of the Lake Children’s Hospital
225-374-1380
Our Lady of the Lake Ascension Hospital
225-647-5057
Our Lady of the Lake Assumption Community Hospital
985-369-4290
Our Lady of Angels Hospital
985-730-6789
Our Lady of Lourdes Hospital
337-470-2866
Our Lady of Lourdes Women and Children’s
337-470-5070
Our Lady of Lourdes Heart Hospital
337-470-1080
St. Dominic Jackson Memorial Hospital
601-200-6000
St. Francis Medical Center
318-966-3461