Approved Formulary
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Medications Requiring Filters
| Medications Requiring Filters | |||
| A | Medication | Preparation Filter | Administration Filter |
| abatacept (Orencia) | Not required. | Use an infusion set with a 0.2 to 1.2 micron filter. | |
| abciximab (ReoPro) | Draw up bolus doses through a 0.2 micron syringe filter or 5 micron filter needle. | For an infusion, use a 0.2 or 0.22 inline filter. | |
| Abelcet - see amphotericin B lipid complex | |||
| agalsidase Beta (Fabrazyme) | Not required. | Use a 0.2 micron inline filter. | |
| Albuked - see albumin 5% and 25% | |||
| albumin 5% and 25% (Albuked, Albuminar, AlbuRx, Albutein, Kedbumin, Plasbumin) | Product information does not indicate a filter is required | Product information does not indicate a filter is required | |
| albumin 5% and 25% (Buminate, Flexbumin,Not required.) | Use a 0.15 micron or smaller administration set. | ||
| Albuminar - see albumin 5% and 25% | |||
| AlbuRx - see albumin 5% and 25% | |||
| Albutein - see albumin 5% and 25% | |||
| alglucosidase alpha (Myozyme) | Not required. | Use a 0.2 micron inline filter. | |
| Alphanate - see antihemophilic Factor/Von Willebrand Factor Complex | |||
| AlphaNine SD - see factor IX, human | |||
| AmBisome - see amphotericin B liposome | |||
| amiodarone (Cordarone) | Not required. | Use a 0.22 micron inline filter. | |
| amphotericin B (Fungizone) | Not required. | May be administered without loss of potency through a 1 micron or greater inline filter. | |
| amphotericin B lipid complex (Abelcet) | Do not use a filter needle to remove from the vial. Use the 5 micron filter needle supplied with the vial to transfer withdrawn contents to an IV bag. Each filter needle may be used for up to four 100 mL vials. | Do NOT use an inline filter. | |
| amphotericin B liposomal (AmBisome) | Do not use a filter needle to withdraw reconstituted AmBisome from the vial. Use the 5 micron filter needle supplied with the vial to transfer withdrawn contents to IV bag. Use one filter needle per vial. | Use a 1 micron or greater inline filter. | |
| andexanet alfa (Andexxa) | Not required. | For IV infusion, use of a 0.2 or 0.22 micron in-line polyethersulfone or equivalent low protein-binding filter is required. | |
| antihemophilic Factor/Von Willebrand Factor Complex (Alphanate) | Use the Mix2Vialc adapter for reconstitution. If more than one vial is required, use a new Mix2Vial adapter for each vial. | Not required. | |
| anti-inhibitor coagulant complex (Feiba NF) | Use the BAXJECT IIc Hi-Flow needleless transfer device during preparation. | Not required. | |
| anti-thymocyte globulin, equine (Atgam) | Not required. | Use a 0.2 to 1 micron inline filter. | |
| anti-thymocyte globulin, rabbit (Thymoglobulin) | Not required. | Use a 0.22 micron inline filter. | |
| Arzerra - see OFATUmumab | |||
| Atgam - see anti-thymocyte globulin, equine | |||
| B | Medication | Preparation Filter | Administration Filter |
| BeneFIX - see factor IX complex, recombinant | |||
| Buminate - see albumin 5% and 25% | |||
| C | Medication | Preparation Filter | Administration Filter |
| cabazitaxel (Jevtana) | Not required. | Use a 0.22 micron inline filter. | |
| cetuximab (Erbitux) | Not required. | Use a 0.22 micron inline filter. | |
| cladribine (Leustatin) | cladribine and bacteriostatic 0.9% sodium chloride should both be filtered through a 0.22 micron syringe filter when preparing 7-day infusions. Filters are not required for preparation of single daily doses. | Not required. | |
| clofarabine (Clolar) | Use a 0.2 micron syringe filter. | Not required. | |
| Clolar - see clofarabine | |||
| Cordarone - see amiodarone | |||
| CytoGam - see cytomegalovirus immune globulin IV, human | |||
| cytomegalovirus immune globulin IV, human (CytoGam) | Not required. | Use a 0.2 to 15 micron inline filter. | |
| D | Medication | Preparation Filter | Administration Filter |
| Dilantin - see phenytoin sodium | |||
| E | Medication | Preparation Filter | Administration Filter |
| epoprostenol (Flolan) | Not required. | Use a 0.22 micron inline filter. | |
| Erbitux - see cetuximab | |||
| etoposide (Toposar) | Not required. | May be administered without loss of potency through a 0.22 micron inline filter. | |
| F | Medication | Preparation Filter | Administration Filter |
| Fabrazyme - see agalsidase Beta | |||
| factor IX complex, human (Profilnine) | Use the filter provided by the manufacturer. | Not required. | |
| factor IX complex, recombinant (BeneFIX) | Use the vial adapter reconstitution device,with builtin filter) provided by the manufacturer. | Not required. | |
| factor IX, human (AlphaNine SD) | Use the Mix2Vialc adapter for reconstitution. If more than one vial is required, use a new Mix2Vial adapter for each vial. | Not required. | |
| factor IX, recombinant, albumin fusion protein,rIX-FP (Idelvion) | Use the Mix2Vialc adapter for reconstitution. If more than one vial is required, use a new Mix2Vial adapter for each vial. | Not required. | |
| factor VIIa, recombinant (NovoSeven RT) | Use the 25 micron filter provided with the prefilled diluent syringe. | Not required. | |
| factor VIII product, human (Humate-P) | Use the Mix2Vialc filter transfer set provided with Humate-P or a double-ended needle and vented filter spike. | Not required. | |
| factor VIII product, human (Koate-DVI) | After reconstituting, use the filter needle provided to draw into a syringe. | Not required. | |
| factor VIII product, human (Monoclate-P) | Use the 5 micron vented filter spike for reconstitution or the 5 micron filter needle to withdraw the reconstituted solution. | Not required. | |
| factor VIII product, recombinant (Helixate-FS) | Use the Mix2Vialc adapter for reconstitution. If more than one vial is required, use a new Mix2Vial adapter for each vial. | Not required. | |
| factor VIII product, recombinant (Recombinate) | Use the BAXJECT IIc Hi-Flow needleless transfer device during preparation. | Not required. | |
| fat emulsion (Intralipids) | Not required. | IMH:1.2 micron filter required, will be sent from pharmacy with each bag. | |
| Feiba NF - see anti-inhibitor coagulant complex | |||
| Flexbumin - see albumin 5% and 25% | |||
| Flolan - see epoprostenol | |||
| Fungizone - see amphotericin B | |||
| H | Medication | Preparation Filter | Administration Filter |
| Helixate-FS - see factor VIII product, recombinant | |||
| Humate-P - see factor VIII product, human | |||
| I | Medication | Preparation Filter | Administration Filter |
| ibritumomab tiuxetan (Zevalin) | Not required. | Use a 0.22 micron inline filter. | |
| Idelvion - see factor IX, recombinant, albumin fusion protein,rIX-FP) | |||
| inFLIXimab (Remicade) | Not required. | Use up to a 1.2 micron inline filter. IMH: 0.2 micron | |
| Intralipids - see fat emulsion | |||
| ipilimumab (Yervoy) | Not required. | Use a 0.2 to 1.2 micron inline filter. | |
| ixabepilone (Ixempra) | Not required. | Use a 0.2 to 1.2 micron inline filter. | |
| J | Medication | Preparation Filter | Administration Filter |
| Jevtana - see cabazitaxel | |||
| K | Medication | Preparation Filter | Administration Filter |
| Kcentra - see prothrombin complex concentrate, human | |||
| Kedbumin - see albumin 5% and 25% | |||
| Keytruda - see pembrolizumab | |||
| Koate-DVI - see factor VIII product, human | |||
| L | Medication | Preparation Filter | Administration Filter |
| Leustatin - see cladribine | |||
| Lucentis - see ranibizumab | |||
| M | Medication | Preparation Filter | Administration Filter |
| mannitol | Filters are not required during preparation. If crystals are present, consider warming mannitol up to 158°F to redissolve crystals, with agitation. Ensure solution cools to room temperature prior to administration. | Use a 0.2 micron inline filter, especially for infusions of 15% or more. Filter sizes may vary among institutions (e.g., 0.2 micron, 5 micron). Consult institution-specific recommendations. | |
| methacholine (Provocholine) | Not required. | When transferring solution from a vial or syringe to nebulizer, use a sterile 0.22 micron filter. | |
| Monoclate-P - see factor VIII product, human | |||
| Myozyme - see alglucosidase alpha | |||
| N | Medication | Preparation Filter | Administration Filter |
| Nexterone - see amiodarone | |||
| NovoSeven RT - see factor VIIa, recombinant | |||
| O | Medication | Preparation Filter | Administration Filter |
| OFATUmumab (Arzerra) | Not required. | Use the administration set, including an inline filter, provided by the manufacturer. | |
| Orencia - see abatacept | |||
| P | Medication | Preparation Filter | Administration Filter |
| PACLitaxel (Taxol) | Not required | Use an inline filter not greater than 0.22 microns. | |
| panitumumab (Vectibix) | Not required. | Use a 0.2 or 0.22 micron inline filter. | |
| pembrolizumab (Keytruda) | Not required. | Use a 0.2 to 5 micron inline or add-on filter. | |
| phenytoin sodium (Dilantin) | Not required. | Use a 0.22 to 0.55 micron inline filter. IMH: For IV infusions, use a 0.22 micron in-line filter. | |
| Plasbumin - see albumin 5% and 25% | |||
| Profilnine - see factor IX complex, human | |||
| prothrombin complex concentrate, human (Kcentra) | Use the Mix2Vialc adapter for reconstitution. If more than one vial is required, use a new Mix2Vial adapter for each vial. | Not required. | |
| Provocholine - see methacholine | |||
| R | Medication | Preparation Filter | Administration Filter |
| ranibizumab (Lucentis) | Use a 5 micron filter needle to draw up contents of vial. | Do not use filter needle for administration. | |
| Recombinate - see factor VIII product, recombinant | |||
| Remicade - see inFLIXimab | |||
| ReoPro - see abciximab | |||
| T | Medication | Preparation Filter | Administration Filter |
| Taxol - see PACLitaxel | |||
| temsirolimus (Torisel) | Not required. | Use an inline filter not greater than 5 microns. Alternatively, a 0.2 to 5 micron add-on filter can be used. Do not use an inline and add-on filter together. | |
| thiotepa (Thioplex) | In order to eliminate haze, filter through a 0.22 micron filter prior to administration. | Not required. | |
| Thymoglobulin - see anti-thymocyte globulin, rabbit | |||
| Toposar - see etoposide | |||
| Torisel - see temsirolimus | |||
| TPN | Not required. | IMH: Use a 0.22 micron inline filter (stocked in storeroom). | |
| V | Medication | Preparation Filter | Administration Filter |
| Vectibix - see panitumumab | |||
| Y | Medication | Preparation Filter | Administration Filter |
| Yervoy - see ipilimumab | |||
| Z | Medication | Preparation Filter | Administration Filter |
| Zevalin - see ibritumomab tiuxetan | |||
| ziv-Afibercept (Zaltrap) | Not required. | Use a 0.2 micron polyethersulfone filter. Do not use nylon or polyvinylidene filters. | |
| last updated: 04/19/2020 | |||