Dosing for posaconazole (Noxafil) Delayed-Release Tablets
Indication
Dose and Duration of Therapy
Prophylaxis of invasive Aspergillus and Candida infections
Loading dose: 300 mg (3 x 100 mg delayed-release tablets) BID on day 1. Maintenance dose: 300 mg (3 x 100 mg delayed-release tablets) daily, starting on day 2. Duration of therapy is based on recovery from neutropenia or immunosuppression.
Dosing for posaconazole (Noxafil) Oral Suspension
Indication
Dose and Duration of Therapy
Prophylaxis of invasive Aspergillus and Candida infections
200 mg (5 mL) TID. The duration of therapy is based on recovery from neutropenia or immunosuppression.
Oropharyngeal Candidiasis
Loading dose: 100 mg (2.5 mL) BID on day 1. Maintenance dose: 100 mg (2.5 mL) daily for 13 days
Oropharyngeal Candidiasis Refractory to itraconazole and/or fluconazole
400 mg (10 mL) BID. Duration of therapy should be based on the severity of the patient's underlying disease and clinical response.
Enteral Drug Administration notes.
Generic (Brand)
Comments and Considerations
Recommendations for Administration with Enteral Nutrition
posaconazole (Noxafil)
Cmax increased 4x and AUC increased 2.5x with high fat meals. Tablet and liquid doses are not interchangeable
Suggest giving each dose with 240 mL of nutritional supplement or 15 mL of canola oil. Not recommended for post-pyloric administration
Add Formweb to your mobile device
Maintenance dose: 300 mg (3 x 100 mg delayed-release tablets) daily, starting on day 2. Duration of therapy is based on recovery from neutropenia or immunosuppression.
Maintenance dose: 100 mg (2.5 mL) daily for 13 days
(Brand)
(Noxafil)