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piperacillin-tazobactam

piperacillin-tazobactam

Drug Name	Form	Strength	Non-Formulary	Restricted	TX Sub	Notes
Zosyn	POWDER FOR INJECTION, INTRAVENOUS	3 g-0.375 g; 4 g-0.5 g
Zosyn	SOLUTION, INTRAVENOUS	3.375 g/50 mL IVPB; 4.5g/100 mL IVPB

Display Extended-spectrum Penicillins Class : 08121616

Medication comments:

Refrigerator / FREEZER item

Per policy, these drugs are subject to renal dosing adjustments by pharmacy.
Generic + Route (Brand) • Indications	Usual Adult Dose Comments	Renal Dosage Adjustments
piperacillin-tazobactam IV (Zosyn^©) • Extended Interval Dosing	4.5 gm q8-12h 4 hour infusion All orders for traditional infusions of piperacillin-tazobactam will be automatically substituted to an EI in adults. Refer to	CrCl > 20: 4.5 gm IV q8h CrCl ≤ 20 mL/min or HD: 4.5 gm IV q12h
piperacillin-tazobactam IV (Zosyn^©) • ED, PACU, and OR	4.5 gm 30 minute infusion x1, subsequent doses will be given via EI Dosing	No adjustment necessary for initial dose

Last updated: Aug. 6, 2025

Renal Adjustment Policy piperacillin-tazobactam subject to adjustments by pharmacy.

UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

This site is intended for the staff of Iredell Health System. While others may view accessible pages, Iredell Health System makes no warranty, express or implied, as to the use of this information outside of Iredell Health System. The content of this policy and procedure document serves as guidance to the delivery of quality patient care. Care providers are expected to exercise critical thinking and situational awareness skills, and in specific situations to take such action as is necessary for the delivery of quality patient care.