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piperacillin-tazobactam

piperacillin-tazobactam
Brand names: Zosyn
Form Strength
POWDER FOR INJECTION, INTRAVENOUS 3 g-0.375 g; 4 g-0.5 g


Medication comments:

Refrigerator / FREEZER item 

Per policy, these drugs are subject to renal dosing adjustments by pharmacy. 
Generic + Route
(Brand)
• Indications
Usual Adult Dose
Comments
Renal Dosage Adjustments
piperacillin-tazobactam IV
(Zosyn©)
• Extended Interval Dosing
3.375 gm q8-12h
4 hour infusion
All orders for traditional infusions of piperacillin-tazobactam will be automatically substituted to an EI in adults. Refer to
CrCl > 20: 3.375 gm IV q8h
CrCl ≤ 20 mL/min or HD: 3.375 gm IV q12h
piperacillin-tazobactam IV
(Zosyn©)
• Traditional Dosing
3.375 gm q6h
or
4.5 gm q6-8h

30 minute infusion
For HAP:
CrCl > 40: 4.5 gm q6h

CrCl 20-29: 4.5 gm q8h or 3.375 gm q6h
CrCl < 20: 4.5 gm q12h
HD/PD: 4.5 gm q12h

Last updated: Apr. 4, 2024
  • Renal Adjustment Policy piperacillin-tazobactam subject to adjustments by pharmacy.


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Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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Care providers are expected to exercise critical thinking and situational awareness skills,
and in specific situations to take such action as is necessary for the delivery of quality patient care.