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methotrexate IM

methotrexate IM
No brands, forms, or strengths have been added for this generic.
Display Antineoplastic Agents Class: 100000
High Alert Drug : Policy

Medication comments:

Reserve Injection for Ectopic Pregnancy during SHORTAGE
Chemo rounding - may round chemo DOWN to nearest vial if dose within ≤ 5% of ordered dose.
Chemo doses will not be rounded up. (Approved 12/18)
High Alert Drug: Chemotherapeutic Agents - Parenteral
 • Stored separately in pharmacy.
 • Pharmacist reviews literature in order to to verify calculations and dose prescribed.
 • Two pharmacists independently verify preparation.
 • No telephone orders. Pre-printed order sheet available.
 • Chemo is administered by specially trained RNs.
 • 2 RNs independently verify pump settings and drug on continuous infusions prior to administration.
 • IV sites are assessed every 2 hours.
 • Drugs are transported in plastic bags/designated transport containers labeled with sticker indicating CHEMOTHERAPY DRUG.
Per policy, these hazardous drugs have special waste requirements. 
Generic (Brand) Waste Requirements
methotrexate (Otrexup, Rasuvo) If > 3% by weight of drug remains ⇒  BLACK BUCKET 
Trace amounts/uncontaminated PPE ⇒  YELLOW BUCKET 
USP <800> Hazardous Drug Assessment of Risk (AOR)
Per policy, these drugs are exempt from USP <800> handling requirements under normal circumstances.
The following outlines must be followed.
generic (Brand) Route [Packaging: Manufacturer ⇒ Dispense] NIOSH Group
Methotrexate (Trexall) IM [Vial ⇒ ] Antineoplastic
Pharmacy:
Receiving /
Storage /
Preparation


Exposure Risk:
moderate
• Handling/preparation PPE Requirements: Single CX glove,  gown , and  CSTD  (as dosage form allows)
• Receiving from Distributor: Designated area/  CX gloves 
• Pharmacy Storage Area: Hazardous, Chemo zip locking bag
• Packaging/Reconstitution Location: n/a
• Compounding (Non-Sterile/Sterile) Location: Required: Med Prep Area with Immediate Use Preparation standards
• Omnicell Load: No
Transport • Transport (dose is placed inside a plastic sealable bag): Double bag
Single  CX gloves 
Nursing:
Storage /
Admin.


Exposure Risk:
moderate
• Handling/administration PPE Requirements: Double CX glove,  gown 
• Storage of Finished dose in Nursing Area/Procedural Area: Picked up from Pharmacy
• Signage on Patient Door Required: Yes
• Manipulation of Dosage Form: 1 vial per syringe - label accordingly
• Special Manipulation for Administration: n/a
Disposal /
Spills
• Disposal of Drug Waste: Full-  black bin 
Trace-  yellow bin 
• Disposol of Used PPE:  Yellow bin 
• Spill management: Wear  CX gloves ;
items used to clean up spill should be placed in a sealed bag and put in  yellow bin 
Reason for exemption of USP<800> Containment Requirements: The act of drawing up an IM dose of methotrexate and giving it immediately is considered administration.
Adult Extravasation Management
Generic (Brand) Vesicant / irritant Local Care
 methotrexate (Otrexup, Rasuvo) N/A Warm compress

Last updated: Apr. 4, 2024


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Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556



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as to the use of this information outside of Iredell Memorial Hospital.
The content of this policy and procedure document serves as guidance to the delivery of quality patient care.
Care providers are expected to exercise critical thinking and situational awareness skills,
and in specific situations to take such action as is necessary for the delivery of quality patient care.