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meropenem

meropenem

Brand names: Merrem

Form	Strength
POWDER FOR INJECTION, INTRAVENOUS	500 mg; 1000 mg

Display Carbapenems Class: 08120708

Medication comments:

Per policy, these drugs are subject to renal dosing adjustments by pharmacy.
Generic + Route (Brand) • Indications	Usual Adult Dose Comments	Renal Dosage Adjustments
meropenem IV (Merrem^©) • CNS infections • Necrotizing fasciitis • Bone/Joint Infection	2 gm q8h (3 hr infusion) Refer to	CrCl > 50 mL/min: No adjustment necessary CrCl 25-49 mL/min: 2 gm q12h CrCl 10-24 mL/min: 1 gm q12h CrCl < 10 mL/min, HD: 1 gm q24h (give dose after HD) Continuous renal replacement therapy (CRRT): 2 gm q12h
meropenem IV (Merrem^©) • Pseudomonas infection (susceptible to meropenem) • Acinetobacter infection (susceptible to meropenem)	1 gm q8h (3 hr infusion) Refer to	CrCl > 50 mL/min: No adjustment necessary CrCl 25-49 mL/min: 1 gm q12h CrCl 10-24 mL/min: 500 mg q12h CrCl < 10 mL/min, HD: 500 mg q24h (give dose after HD) Continuous renal replacement therapy (CRRT): 1 gm q12h
meropenem IV (Merrem^©) • Pneumonia • Intra-abdominal infection • Neutropenic fever • Infections caused by ESBLs or cefTRIAXone-resistant organisms	500 mg q6h (30 min infusion) Refer to	CrCl > 50 mL/min: No adjustment necessary CrCl 25-49 mL/min: 500 mg q8h CrCl 10-24 mL/min: 500 mg q12h CrCl < 10 mL/min, HD: 500 mg q24h (give dose after HD) Continuous renal replacement therapy (CRRT): 500 mg q6h

Per policy, these antibiotic medications may be given IV push.
generic (Brand)	Reconstitution Amount	Reconstitution Diluent	Give over
Copy/Paste comments for PharmNet
meropenem (Merrem)	500 mg vial = 10 ml	Sterile Water for Injection	3-5 mins
Dilute with 10 ml Sterile Water for Injection and give over 3-5 mins.

No IV Push for ≥ 1 gm doses, give via IVPB over 3 hours.

Last updated: Jul. 26, 2021

Renal Adjustment Policy meropenem subject to adjustments by pharmacy.

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

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as to the use of this information outside of Iredell Memorial Hospital.
The content of this policy and procedure document serves as guidance to the delivery of quality patient care.
Care providers are expected to exercise critical thinking and situational awareness skills,
and in specific situations to take such action as is necessary for the delivery of quality patient care.