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Approved Formulary
Search results for:
darifenacin
darifenacin
- Restricted Medications Non-Formulary
Brand names: Enablex
| Form | Strength |
|---|---|
| TABLET, EXTENDED RELEASE, ORAL | 7.5 mg |
Display Genitourinary Smooth Muscle Relaxants Class:
861200
Medication comments:
| 2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults. | |
|---|---|
| Medication: | darifenacin (Enablex) |
| Criteria 2: Potentially inappropriate medication use in older adults due to drug–disease or drug–syndrome interactions that may exacerbate the disease or syndrome. (Table 3) | |
| Drug(s) ⇆ disease or syndrome | anticholinergics ⇄ Delirium |
| Rationale | Avoid in older adults with or at high risk of delirium because of the potential of inducing or worsening delirium. |
| Recommendation | Avoid |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
| Drug(s) ⇆ disease or syndrome | anticholinergics ⇄ Dementia or cognitive impairment |
| Rationale | Avoid because of adverse CNS effects. If used, periodic deprescribing attempts should be considered to assess ongoing need and/or the lowest effective dose. |
| Recommendation | Avoid |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
| Drug(s) ⇆ disease or syndrome | anticholinergics ⇄ History of falls or fractures |
| Rationale | May cause ataxia, impaired psychomotor function, syncope, or additional falls. If one of the drugs must be used, consider reducing the use of other CNS-active medications that increase the risk of falls and fractures. (i.e., anticholinergics, selected antidepressants, antiepileptics, antipsychotics, sedative/hypnotics including benzodiazepines and, Nonbenzodiazepine benzodiazepine receptor agonist hypnotics, opioids) and implement other strategies to reduce fall risk. |
| Recommendation | Avoid unless safer alternatives are not available. |
| Quality of evidence: High, Strength of Recommendation: Strong | |
| Criteria 4: Potentially clinically important drug-drug interactions that should be avoided in older adults. (Table 5) | |
| Interacting drug(s) or class(es) | anticholinergics ⇄ anticholinergics |
| Risk Rationale | Use of more than one medication with anticholinergic properties increases the risk of cognitive decline, delirium, and falls or fractures. |
| Recommendation | Avoid; minimize the number of anticholinergic drugs Click for list. |
| Quality of evidence: Moderate, Strength of Recommendation: Strong | |
Last updated: Sep. 18, 2025