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cefuroxime

cefuroxime

Brand names: Ceftin, Zinacef

Form	Strength
POWDER FOR INJECTION, INJECTABLE	1.5 g; 750 mg
TABLET, ORAL	250 mg

Display Second Generation Cephalosporins Class: 08120608

Medication comments:

Per policy, these drugs are subject to renal dosing adjustments by pharmacy.
Generic + Route (Brand) • Indications	Usual Adult Dose Comments	Renal Dosage Adjustments
cefuroxime IV/IM (Zinacef^©)	0.75-1.5 gm q8-12h	CrCl ≥ 30: No adjustment necessary CrCl 10-30: 0.75-1.5 gm q12h CrCl < 10, HD/PD: 0.75-1.5 gm q24h
cefuroxime PO (Ceftin^©)	250-500 mg q12h	CrCl ≥ 30: No adjustment necessary CrCl 10-30: 250 mg q24h CrCl < 10, HD/PD: 250 mg q48h

Per policy, orders for these non-formulary agents will be changed to formulary equivalents.
Non-Formulary Agent	Formulary Equivalent
cefuroxime (Ceftin) liquid	cefprozil (Cefzil) liquid

Per policy, these antibiotic medications may be given IV push.
generic (Brand)	Reconstitution Amount	Reconstitution Diluent	Give over
Copy/Paste comments for PharmNet
cefuroxime (Zinacef)	750 mg vial = 10 ml	Sterile Water for Injection	3-5 mins
Dilute with 10 ml Sterile Water for Injection and give over 3-5 mins.
cefuroxime (Zinacef)	1,500 mg vial = 16 ml	Sterile Water for Injection	3-5 mins
Dilute with 16 ml Sterile Water for Injection and give over 3-5 mins.

Enteral Drug Administration notes.
Generic (Brand)	Comments and Considerations	Recommendations for Administration with Enteral Nutrition
cefuroxime (Ceftin)	Tablets and oral suspension are not bioequivalent. Do NOT crush tablets (risk of sensitization), unacceptable taste	Use available suspension or disperse tablet (do not crush) in 20 mL water prior to administration

Last updated: May. 1, 2024

Renal Adjustment Policy cefuroxime subject to adjustments by pharmacy.

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

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as to the use of this information outside of Iredell Memorial Hospital.
The content of this policy and procedure document serves as guidance to the delivery of quality patient care.
Care providers are expected to exercise critical thinking and situational awareness skills,
and in specific situations to take such action as is necessary for the delivery of quality patient care.