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azithromycin

azithromycin

Brand names: Zithromax

Form	Strength
POWDER FOR INJECTION, INTRAVENOUS	500 mg
SUSPENSION, ORAL	250 mg / 5 ml; 500 mg / 5 ml
TABLET, ORAL	250 mg; 500 mg

Display Other Macrolides Class: 08121208

Medication comments:

Per policy, these drugs are subject to renal dosing adjustments by pharmacy.
Generic + Route (Brand) • Indications	Usual Adult Dose Comments	Renal Dosage Adjustments
azithromycin IV (Zithromax^©)	500 mg daily	No adjustment necessary
azithromycin PO (Zithromax^©)	250-500 mg daily (500-1,000 mg single dose for specific indications)	No adjustment necessary

Per policy, these drugs may be converted from IV to PO in patients who meet criteria.
Generic (Brand)	Population	IV Dose	PO Dose	Notes
azithromycin (Zithromax)	adult	250 mg IV q24h	250 mg PO q24h	Although azithromycin has low bioavailability, it is well-distributed to tissues.
	adult	500 mg IV q24h	500 mg PO q24h
	pediatric	5-10 mg/kg q24h	5-10 mg/kg q24h (max: 500 mg/day)

Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics
Medication:	azithromycin (Zithromax)
Key Potentially Inappropriate Drugs in Pediatrics (KIDs) List: Second Edition (Table 1)
Drug	macrolides
Risk/Rationale	Hypertrophic pyloric stenosis (risk greater for erythromycin > azithromycin)
Recommendation	Avoid in younger than 1 mo except for Bordetella pertussis (azithromycin) or Chlamydia trachomatis pneumonia (azithromycin and erythromycin). Caution in younger than 1 mo for Ureaplasma (azithromycin)
Quality of evidence: High, Strength of Recommendation: Strong

Last updated: Sep. 25, 2025

Renal Adjustment Policy azithromycin subject to adjustments by pharmacy.
IV to PO Conversion Policy Policy

UpToDate Lexidrug

Pharmacy Contact Info:

Main Inpatient Pharmacy: ext 4599, 3503
Fax: 704-878-7283

Director of Pharmacy - Randi Raynor, PharmD: ext 4501
Clinical Coordinator - Laura Rollings, PharmD: ext 4597
Pharmacy Informaticist - Stephen Pringle, PharmD: ext 7645
Pharmacy Technician Supervisor - Amy Wingler, CPhT: ext 7385
Pharmacy Automation Coordinator (Omnicell) - Melissa Fulford, CPhT: ext 3556

This site is intended for the staff of Iredell Health System. While others may view accessible pages, Iredell Health System makes no warranty, express or implied, as to the use of this information outside of Iredell Health System. The content of this policy and procedure document serves as guidance to the delivery of quality patient care. Care providers are expected to exercise critical thinking and situational awareness skills, and in specific situations to take such action as is necessary for the delivery of quality patient care.