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aspirin

aspirin
Brand names: ASA, Ascriptin, Aspirin Child Chewable, Ecotrin
Form Strength
DELAYED RELEASE TABLET, ORAL 325 mg
SUPPOSITORY, RECTAL 300 mg
TABLET, CHEWABLE, ORAL 81 mg
TABLET, ORAL 325 mg
Display Salicylates Class: 28080424
Medication comments:

Refrigerator item (suppository) 

Per policy, orders for these non-formulary agents will be changed to formulary equivalents.  
Non-Formulary Agent Formulary Equivalent
aspirin buffered (Ascriptin) 325 mg aspirin EC (Ecotrin) 325 mg
aspirin EC 81 mg aspirin chewable 81 mg
Anticoagulant / Antiplatelet Stoppage For Procedures
generic (Brand) Dept. Procedure Type
(hover over entry for examples)		 Stop Medication Prior To Procedure Restart after:
aspirin
325 mg		 Anesthesia High-risk Primary prophylaxis: 6 days; Secondary prophylaxis: Shared assessment and risk stratification Restart after 24 hours
Intermediate-risk Requires shared assessment and risk stratification Restart after 24 hours
Low-risk No hold Restart after 24 hours
Patients with high risk of bleeding (eg, old age, history of bleeding tendency, concurrent uses of other anticoagulants/antiplatelets, liver cirrhosis or advanced liver disease, and advanced renal disease) undergoing low- or intermediate-risk procedures should be treated as intermediate or high risk, respectively.
Radiology
 Invasive Procedures 7 days
Paracentesis/Thoracentesis No hold
Surgery High-risk 7 days Restart after 24 hours
Low-risk No Hold Restart after 24 hours
aspirin
81 mg		 Anesthesia High-risk Primary prophylaxis: 6 days; Secondary prophylaxis: Shared assessment and risk stratification Restart after 24 hours
Intermediate-risk Requires shared assessment and risk stratification Restart after 24 hours
Low-risk No hold Restart after 24 hours
Patients with high risk of bleeding (eg, old age, history of bleeding tendency, concurrent uses of other anticoagulants/antiplatelets, liver cirrhosis or advanced liver disease, and advanced renal disease) undergoing low- or intermediate-risk procedures should be treated as intermediate or high risk, respectively.
Radiology
 Invasive Procedures 3 days
Paracentesis/Thoracentesis No hold
Surgery High-risk 7 days Restart after 24 hours
Low-risk No Hold Restart after 24 hours
2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults.
Medication: aspirin
Criteria 1: Potentially inappropriate medication use in older adults. (Table 2)
Comments for primary prevention of cardiovascular disease
Drug(s) aspirin
Rationale Risk of major bleeding from aspirin increases markedly in older age. Studies suggest a lack of net benefit and potential for net harm when initiated for primary prevention in older adults. There is less evidence about stopping aspirin among long-term users, although similar principles for initiation may apply.
Note: aspirin is generally indicated for secondary prevention in older adults with established cardiovascular disease.
Recommendation Avoid initiating aspirin for primary prevention of cardiovascular disease.
Consider deprescribing aspirin in older adults already taking it for primary prevention.
 Quality of evidence: High, Strength of Recommendation: Strong
 
Comments > 325 mg/day
Drug(s) non-COX-2-selective NSAIDs, oral
Rationale Increased risk of GI bleeding or peptic ulcer disease in high-risk groups, including those >75 years old or taking oral or parenteral corticosteroids, anticoagulants, or antiplatelet agents; use of proton-pump inhibitor or miSOPROStol reduces but does not eliminate risk. Upper GI ulcers, gross bleeding or perforation caused by NSAIDs occur in ~1% of patients treated for 3-6 months and in ~2%-4% of patients treated for 1 year; these trends continue with longer duration of use. Also can increase blood pressure and induce kidney injury. Risks are dose-related.
Recommendation Avoid chronic use unless other alternatives are not effective and the patient can take a gastroprotective agent (proton-pump inhibitor or miSOPROStol).
Avoid short-term scheduled use in combination with oral or parenteral corticosteroids, anticoagulants or antiplatelet agents unless other alternatives are not effective and the patient can take a gastroprotective agent (proton-pump inhibitor or miSOPROStol).
 Quality of evidence: Moderate, Strength of Recommendation: Strong
 
Criteria 2: Potentially inappropriate medication use in older adults due to drug–disease or drug–syndrome interactions that may exacerbate the disease or syndrome. (Table 3)
Comments > 325 mg/day
Drug(s) ⇆ disease or syndrome NSAIDs and COX-2 inhibitors ⇄ Heart failure
Rationale Potential to promote fluid retention and/or exacerbate heart failure.
Recommendation Use with caution in patients with heart failure who are asymptomatic; avoid in patients with symptomatic heart failure.
 Quality of evidence: Moderate, Strength of Recommendation: Strong
 
Comments > 325 mg/day
Drug(s) ⇆ disease or syndrome aspirin ⇄ History of gastric or duodenal ulcers
Rationale May exacerbate existing ulcers or cause new/additional ulcers
Recommendation Avoid unless other alternatives are not effective and the patient can take a gastroprotective agent (i.e., proton-pump inhibitor or miSOPROStol).
 Quality of evidence: Moderate, Strength of Recommendation: Strong
 
Criteria 5: medications that should be avoided or have their dosage reduced with varying levels of kidney function in older adults. (Table 6)
Comments > 325 mg/day
CrCl (mL/min) at which action is required <30
Rationale NSAIDs (oral and parenteral) may increase the risk of acute kidney injury and a further decline in kidney function.
Recommendation Avoid
 Quality of evidence: Moderate, Strength of Recommendation: Strong
Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics 
Medication: aspirin
Key Potentially Inappropriate Drugs in Pediatrics (KIDs) List: Second Edition (Table 1)
Drug salicylates
Risk/Rationale Reye syndrome
Recommendation Caution in 18 yr of age and younger with suspicion of viral illness (influenza and varicella)
 Quality of evidence: Very low, Strength of Recommendation: Weak
Last updated: Nov. 2, 2025
UpToDate Lexidrug

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