100-800 mg/day • Doses > 300 mg should be given in divided doses. • Higher doses of allopurinol should not be adjusted in patients who are suspected to be or are currently in tumor lysis syndrome (TLS).
Dose evaluation to occur only upon order entry.CrCl > 20: No adjustment necessary CrCl 10-20: 200 mg daily CrCl 3-10: ≤ 100 mg daily CrCl < 3: ≤ 100 mg/dose at extended intervals
Last updated: May. 24, 2021
Renal Adjustment Policy allopurinol subject to adjustments by pharmacy.
(Brand)
• Indications
Comments
(Zyloprim©)
• Doses > 300 mg should be given in divided doses.
• Higher doses of allopurinol should not be adjusted in patients who are suspected to be or are currently in tumor lysis syndrome (TLS).
CrCl > 20: No adjustment necessary
CrCl 10-20: 200 mg daily
CrCl 3-10: ≤ 100 mg daily
CrCl < 3: ≤ 100 mg/dose at extended intervals