The schedule for pantoprazole should be the same as that prescribed for the non-workhorse PPI.
Protonix DR granules for oral suspension are classified as non-formulary, not stocked. Interchange to Protonix tablets if possible. Pantoprazole tablets are delayed release and cannot be crushed. Use Prevacid SoluTab if for pediatric dosing or enteral tube administration.
Per P&T approval, pharmacists are now able to discontinue inappropriately prescribed Proton Pump Inhibitors (all dosage forms of pantoprazole and omeprazole) as COSIGN REQUIRED in adult patients without proper indication for stress ulcer prophylaxis or other appropriate indication as indicated below.
**Exclusions: PPIs prescribed by GI physicians, home medications, and the criteria listed below.**
Criteria for use as stress ulcer prophylaxis: •Mechanical ventilation > 48 hours •Coagulopathy (in absence of an anticoagulant) • Platelet count < 50, INR > 1.5, or PTT 2x baseline •Use of 2 antiplatelet agents (Clopidogrel, aspirin, ticagrelor, etc.) •Ulcer or GI bleed in the past year •Major trauma •Traumatic head injury or spinal cord injury •Partial hepatectomy/ hepatic failure •Patients with TWO or more of the following risk factors: •Sepsis •ICU length of stay > 7 days •Occult bleeding > 6 days •High dose steroids Dexamethasone: 10 mg/day Methylprednisolone: 50 mg/day Prednisone: 60 mg/day Hydrocortisone: 250 mg/day
PPI indications for treatment or maintenance prophylaxis: •Gastroesophageal Reflux Disease (GERD) •Gastric or duodenal ulcer •GI bleed •Erosive esophagitis •Helicobacter pylori treatment •Chronic NSAID therapy •Zollinger-Ellison Syndrome •Other appropriate maintenance therapy
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ORDERED FORMULATION
THERAPEUTIC INTERCHANGE
pantoprazole (Protonix)
pantoprazole (Protonix)
Protonix DR tablet and DR oral suspension medication guide
The schedule for pantoprazole should be the same as that prescribed for the non-workhorse PPI.
Protonix DR granules for oral suspension are classified as non-formulary, not stocked. Interchange to Protonix tablets if possible. Pantoprazole tablets are delayed release and cannot be crushed. Use Prevacid SoluTab if for pediatric dosing or enteral tube administration.
Automatic IV to PO conversion per IV to oral conversion guidelines. IV to PO Conversion Guidelines
Per P&T approval, pharmacists are now able to discontinue inappropriately prescribed Proton Pump Inhibitors (all dosage forms of pantoprazole and omeprazole) as COSIGN REQUIRED in adult patients without proper indication for stress ulcer prophylaxis or other appropriate indication as indicated below.
**Exclusions: PPIs prescribed by GI physicians, home medications, and the criteria listed below.**
Criteria for use as stress ulcer prophylaxis:
•Mechanical ventilation > 48 hours
•Coagulopathy (in absence of an anticoagulant)
• Platelet count < 50, INR > 1.5, or PTT 2x baseline
•Use of 2 antiplatelet agents (Clopidogrel, aspirin, ticagrelor, etc.)
•Ulcer or GI bleed in the past year
•Major trauma
•Traumatic head injury or spinal cord injury
•Partial hepatectomy/ hepatic failure
•Patients with TWO or more of the following risk factors:
•Sepsis
•ICU length of stay > 7 days
•Occult bleeding > 6 days
•High dose steroids
Dexamethasone: 10 mg/day
Methylprednisolone: 50 mg/day
Prednisone: 60 mg/day
Hydrocortisone: 250 mg/day
PPI indications for treatment or maintenance prophylaxis:
•Gastroesophageal Reflux Disease (GERD)
•Gastric or duodenal ulcer
•GI bleed
•Erosive esophagitis
•Helicobacter pylori treatment
•Chronic NSAID therapy
•Zollinger-Ellison Syndrome
•Other appropriate maintenance therapy
Reviewed: October 28, 2008 (Protonix DR granules)