ORDERED FORMULATION

THERAPEUTIC INTERCHANGE

 NOTES

palonosetron (Aloxi)

• 0.25 mg IV
• 0.5 mg PO

ondansetron (Zofran)

• 16 mg
• 16 mg PO (tablets, liquid or ODT)

• Standardize ondansetron piggyback sol’n to 50 mL NS
• ondansetron is a 1^st line workhorse drug for palonosetron
• Maximum ondansetron IV or PO dose is 16 mg

palonosetron (Aloxi)

• 0.25 mg IV
• 0.25 mg IV
• 0.5 mg PO

granisetron (Kytril)

• 1 mg IV
• 2 mg PO
• 2 mg PO

If patient unable to tolerate oral medication interchange to IV granisetron; interchange to granisetron if ondansetron not available