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hepatitis B vaccine

hepatitis B vaccine
Drug Name Form Strength Formulary Unrestricted Formulary Restricted Non-Formulary Interchange
Recombivax HB Pediatric/Adolescent SUSPENSION, INTRAMUSCULAR 5 mcg/0.5 mL      
Engerix-B Pediatric SUSPENSION, INTRAMUSCULAR 10 mcg/0.5 mL    
Recombivax HB Adult SUSPENSION, INTRAMUSCULAR 10 mcg/mL, 40 mcg/mL    
Engerix-B Adult SUSPENSION, INTRAMUSCULAR 20 mcg/mL      
Heplisav-B SUSPENSION, INTRAMUSCULAR 20 mcg/0.5 mL      
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CLASS
801200
Comments:

Preferred Vaccine (Contract)

Adults: Engerix B Adult (GSK)

Pediatrics: Recombivax HB Pediatric/Adolescent (Merck)

 

Heplisav-B is restricted to Employee Health for adult patients not on dialysis.

If Heplisav-B is ordered inpatient,  the pharmacists should contact the prescriber to recommend the use of Engerix-B.

 

ORDERED FORMULATION

THERAPEUTIC INTERCHANGE

NOTES

Engerix B—Usual Schedule (0, 1, 6 months)

  • Infant³: 10 mcg/0.5 mL
  • Children 0-10 years: 10 mcg/0.5 mL
  • Adolescents 11-19 years: 10 mcg/0.5 mL

Recombivax HB—Usual Schedule (0, 1, 6 months)²

  • Infant4: 5 mcg/0.5 mL
  • Children 0-10 years: 5 mcg/0.5 mL
  • Adolescents 11-19 years: 5 mcg/0.5 mL

 

Engerix B—Alternative Schedule¹ (0, 1, 2, 12 months)                         

  • Pediatric/Adolescents—0-19 years: 10 mcg/0.5 mL

Recombivax HB—Alternative Schedule¹ (0, 1, 2, 12 months)

  • Pediatric/Adolescent—0-19 years: 5 mcg/0.5 mL
  

Recombivax HB—Usual Schedule (0, 1, 6 months)²

  • Adults >20 years: 10 mcg/1 mL
  • Adult pre-dialysis or dialysis: 40 mcg/1 mL

Engerix B—Usual Schedule (0, 1, 6 months)

  • Adults >20 years: 20 mcg/1 mL
  • Adult pre-dialysis or dialysis: 40 mcg/2 mL (may use 20 mcg x 2 vials in 1 or 2 injections)

 

Dialysis patients should receive doses at 0, 1, 2 and 6 months

Dialysis formulation may ONLY be used in dialysis patients

Recombivax HB—Alternative Schedule¹ (0, 1, 2, 12 months)

  • Adults >20 years: 10 mcg/1 mL

Engerix B—Alternative Schedule¹ (0, 1, 2, 12 months)                         

  • Adults >20 years: 20 mcg/1 mL
  

 

The usual dosing schedule is 0, 1, 6 months; alternate dosing schedule is 0, 1, 2, 12 months.

  1. Alternate dosing schedule is recommended for: neonates born to hepatitis-B infected mothers, anyone who may have recently been exposed to the virus, and certain travelers to high-risk areas.
  2. If the suggested formulation is not available, the appropriate dosage can be achieved from another formulation provided that the total volume of vaccine administered does not exceed 1 mL.  However, the dialysis formulation may only be used in adult dialysis patients.
  3. If the 4-dose schedule for Engerix-B is used, give the third dose at 2 months of age and the fourth dose at 12 to 18 months of age.
  4. Infants and children who initiated their vaccination series with the 2.5 mcg dose may complete the 3-dose regimen with either the 2.5 mcg or 5 mcg dose.  Begin all new vaccine regimens with the 5 mcg dose for infants and children.

Updated: May 2010, June 2018 (GSK Contract), April 2020 (Recombivax available), September 2020 (Heplisav-B), April 2023 (Heplisav-B)

 

Last updated: May. 5, 2023






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