Emergent Reversal of Oral Anticoagulants

Hemophilia Blood Factor Flow Diagram

Approved Profilnine prescribers:

cardiologists, cardiovasular surgeons, emergency department physicians, hematologists, neurologists, neurosurgeons, vascular surgeons, and trauma surgeons.

Profilnine (or Profilnine with NovoSeven) will be therapeutically interchanged with FEIBA for emergent reversal of ORAL anticoagulants -- unless Profilnine is ordered as no substitution. See FEIBA monograph for more information and Emergent Reversal of Oral Anticoagulants.

Profilnine uses:

1. Patients with Factor IX deficiency due to hemophilia B.
2. Patient is on ECMO. ECMO related bleeding.
3. Patient has received NovoSeven < 4 hours prior to prothrombin complex concentrate (PCC) order.
4. No substitution order.

If Profilnine meets all criteria for prescribed indication, reference dosing guidelines above.

Reviewed: April 24, 2012, and  October 23, 2012, and 25 October 2016 (Profilnine SD), and 28 March 2017, and 25 April 2017, and 28 Aug 2018

• Micromedex
• UpToDate
• Lippincott Advisor