Medications not yet evaluated by P&T are considered NON-FORMULARY. Always check 2 unique patient identifiers - NAME and DATE OF BIRTH - at every step!
Please be sure to document all clinical activities daily.
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Promethazine

promethazine
  • Formulary Not to be given IV push.
  • Formulary For parenteral shortage situation, see interchange to prochlorperazine (Compazine) injection below.
Drug Name Form Strength Formulary Unrestricted Formulary Restricted Non-Formulary Interchange
Phenergan, Prorex SOLUTION, INJECTABLE 25 mg/mL    
Phenergan, Phenadoz, Promethegan SUPPOSITORY, RECTAL 12.5 mg, 25 mg, 50 mg      
Phenergan SYRUP, ORAL 6.25 mg/5 mL      
Phenergan, Promacot TABLET, ORAL 12.5 mg, 25 mg      
VIEW MORE First Generation Antihistamines, Anxiolytics, Sedatives, and Hypnotics, Miscellaneous
High Alert Drug : Policy
Comments:

Injectable form of promethazine is a HIGH-RISK/HIGH-ALERT drug - use extreme caution

 

Category A Vesicant: See Management of Extravasation of Irritant and Vesicant Drugs (Non-Chemotherapy) - ADULTS and Management of Extravasation of Irritant and Vesicant Drugs (Non-Chemotherapy) PEDIATRIC

Powerplans: HOSP Vesicant Extravasation Management Orders and PEDS Vesicant Extravasation Management Orders

 

PHENERGAN injection is allowed via IM administration. IV push administration of promethazine is banned. IF GIVEN IV, MUST BE GIVEN IVPB. CENTRAL LINE PREFERRED. USE SUPPOSITORY ROUTE WHEN POSSIBLE. As long as prochlorperazine injection is available, the pharmacist may automatically interchange orders for IV promethazine to prochlorperazine (if desired by nurse and/or patient).

Ordered Formulation Therapeutic Interchange Notes
prochlorperazine (Compazine)
  • 10 mg IV/IM
 ondansetron (Zofran)
  • 4 mg IV/IM
 Interchange during prochlorperazine injection  shortage. Other dosages will be interchanged in a proportional ratio.
prochlorperazine (Compazine)
  • 10 mg IV/IM
 promethazine (Phenergan)
  • 25 mg IVPB/IM
 Interchange during prochlorperazine injection  shortage if patient does not tolerate ondansetron. Other dosages will be interchanged in a proportional ratio.

Interchange from promethazine (Phenergan) injection to prochlorperazine (Compazine) injection during promethazine shortage. 

Ordered Formulation Therapeutic Interchange
promethazine (Phenergan, Prorex)
  • 12.5 mg IVPB/IM

prochlorperazine (Compazine)

  • 5 mg IV/IM
promethazine (Phenergan, Prorex)
  • 25 mg IVPB/IM

prochlorperazine (Compazine)

  • 10 mg IV/IM
Last updated: May. 13, 2026






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