meropenem
Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines (Note: “Therapeutic Interchange” should be placed in the order comments
Carbapenems
MedicationOrdered
Brand Name
Available Dosages
Formulary Medication
Creatinine Clearance
EquivalentDose
Frequency
Doripenem
Doribax
250mg, 500mg
Meropenem
> 50 ml/min
0.5g (2g for meningitis)
q6h (q8h for meningitis)
26-50ml/min
q8h (q12h for meningitis)
10-25ml/min
0.5g (1g for meningitis)
q12h
Imipenem-cilastatin
Primaxin
250mg, 500mg, 1000mg
<10ml/min
q24h
Hemodialysis
0.5g
q24h (after HD)
CAPD
CRRT
q6h (q12h for meningitis)
Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines
(Note: “Therapeutic Interchange” should be placed in the order comments
Carbapenems
Medication
Ordered
Brand Name
Available Dosages
Formulary Medication
Creatinine Clearance
Equivalent
Dose
Frequency
Doripenem
Doribax
250mg, 500mg
Meropenem
> 50 ml/min
0.5g (2g for meningitis)
q6h (q8h for meningitis)
26-50ml/min
0.5g (2g for meningitis)
q8h (q12h for meningitis)
10-25ml/min
0.5g (1g for meningitis)
q12h
Imipenem-cilastatin
Primaxin
250mg, 500mg, 1000mg
<10ml/min
0.5g (1g for meningitis)
q24h
Hemodialysis
0.5g
q24h (after HD)
CAPD
0.5g (1g for meningitis)
q24h
CRRT
0.5g (1g for meningitis)
q6h (q12h for meningitis)