Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines (Note: “Therapeutic Interchange” should be placed in the order comments
Cephalosporins
Medication Ordered
Brand Name
Ordered Dosage
Frequency
Formulary Medication
Equivalent Dose
Frequency
Cefotaxime
Claforan
1gm
q8h or q12h
Ceftriaxone
1gm
q24h
2gm
q8h or q12h
2gm
q24h
1gm
q4h or q6h
1gm
q12h
2gm
q4h or q6h
2gm
q12h
Creatinine Clearance
< 10 ml/min
Call MD with Recommendation based on diagnosis (see lexicomp)
Ceftazidime
Fortaz
1gm
q8h
Cefepime
1gm
q12h
2gm
q8h
2gm
q12h
1gm
q12h
1gm
Q24h
Creatinine Clearance
< 60 ml/min
Call MD with Recommendation based on diagnosis (see lexicomp)
Exceptions: These agents are approved for use in pediatric patients
Drug Name
Common Side Effects
cefotaxime
GI: diarrhea, vomiting
rash
inflammation/tenderness at injection site
Last updated: Dec. 8, 2021
Therapeutic Interchange: T.I.
Restricted: cefotaxime (Claforan) is restricted to pediatric patients; convert cefotaxime to ceftriaxone (Rocephin) in Adults
Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines
(Note: “Therapeutic Interchange” should be placed in the order comments
Cephalosporins
Medication Ordered
Brand Name
Ordered Dosage
Frequency
Formulary Medication
Equivalent Dose
Frequency
Cefotaxime
Claforan
1gm
q8h or q12h
Ceftriaxone
1gm
q24h
2gm
q8h or q12h
2gm
q24h
1gm
q4h or q6h
1gm
q12h
2gm
q4h or q6h
2gm
q12h
Creatinine Clearance
< 10 ml/min
Call MD with Recommendation based on diagnosis (see lexicomp)
Ceftazidime
Fortaz
1gm
q8h
Cefepime
1gm
q12h
2gm
q8h
2gm
q12h
1gm
q12h
1gm
Q24h
Creatinine Clearance
< 60 ml/min
Call MD with Recommendation based on diagnosis (see lexicomp)
Exceptions: These agents are approved for use in pediatric patients
cefotaxime