cefadroxil (non-formulary)
Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines (Note: “Therapeutic Interchange” should be placed in the order comments
Cephalosporins (Pediatrics)
Medication Ordered
Brand Name
Ordered Dosage
Frequency
Formulary Medication
Equivalent Dose
Cefadroxil
Duricef
15mg/kg
Q12hours
Cephalexin
12.5mg/kg
Q6hours
1 gm
250mg
Creatinine
Clearance
< 40mL/min
Q8hours
< 10mL/min
Cefprozil
Cefzil
Cefuroxime
Creatinine Clearance
Q24hours
Cefpodoxime
Vantin
5mg/kg
Cefdinir
7mg/kg
200mg
300mg
< 30mL/min
Hemodialysis
After HD
Oral Cephalosporins:Pharmacy Automatic Therapeutic Substitution & Renal Dose Adjustment for Adults
1000 mg
Q12 hours
500 mg
Q6 hours
< 50 mL/min
< 10 mL/min
Q24 hours
250 mg
Q24 hours post HD
Medications Approved for Automatic Therapeutic Interchange Dosage Conversion Guidelines
(Note: “Therapeutic Interchange” should be placed in the order comments
Cephalosporins (Pediatrics)
Medication Ordered
Brand Name
Ordered Dosage
Frequency
Formulary Medication
Equivalent Dose
Frequency
Cefadroxil
Duricef
15mg/kg
Q12hours
Cephalexin
12.5mg/kg
Q6hours
1 gm
Q12hours
250mg
Q6hours
Creatinine
Clearance
< 40mL/min
12.5mg/kg
Q8hours
250mg
< 10mL/min
12.5mg/kg
Q12hours
250mg
Cefprozil
Cefzil
15mg/kg
Q12hours
Cefuroxime
15mg/kg
Q12hours
250mg
Q12hours
250mg
Creatinine Clearance
< 10mL/min
15mg/kg
Q24hours
250mg
Cefpodoxime
Vantin
5mg/kg
Q12hours
Cefdinir
7mg/kg
Q12hours
200mg
Q12hours
300mg
Creatinine Clearance
< 30mL/min
7mg/kg
Q24hours
300mg
Hemodialysis
7mg/kg
After HD
Oral Cephalosporins:
Pharmacy Automatic Therapeutic Substitution & Renal Dose Adjustment for Adults
Medication Ordered
Ordered Dosage
Frequency
Formulary Medication
Equivalent Dose
Frequency
Cefadroxil
1000 mg
Q12 hours
Cephalexin
500 mg
Q6 hours
Creatinine
Clearance
< 50 mL/min
500 mg
Q12 hours
< 10 mL/min
500 mg
Q24 hours
Hemodialysis
250 mg
Q24 hours post HD